Indonesiana volume 4: merayakan kebudayaan

Majalah Indonesiana edisi ini terbit membahas dua topik menarik, sama-sama tentang perayaan. Pertama, perayaan kebudayaan. Tentu banyak berlangsung perayaan budaya di mana-mana. Tapi, pada akhir tahun 2018 menjelang majalah ini terbit, di Indonesia berlangsung perayaan besar kebudayaan, Kongres Kebudayaan Indonesia (KKI) 2018. Mengambil momentum merayakan satu abad Kongres Kebudayaan pertama 1918 silam, KKI 2018 yang diikuti tujuh ribu peserta berhasil menyepakati satu dokumen Srategi Kebudayaan Nasional. Selain itu, KKI 2018 juga menghasilkan suatu resolusi kebudayaan. Inilah dua dokumen penting yang berlaku untuk 20 tahun dan diyakini dapat dijadikan pedoman untuk memajukan kebudayaan menuju visi Indonesia Bahagia. Kedua, perayaan kehidupan. Majalah ini hendak memberi sajian penting kepada pembaca tentang berbagai perayaan unik yang diadakan setiap insan di Indonesia,mulai dari sebelum kelahiran hingga sesudah kematiannya. Perayaan-perayaan kehidupan itu sendiri sudah membudaya, dan menjadi bagian dari kebudayaan Indonesia yang patut terus dikembangkan dan dimajukan

Terminal Epidermal Differentiation of Human Keratinocytes Grown in Chemically Defined Medium on Inert Filter Substrates at the Air-Liquid Interface

A fully differentiated epithelium having the features of epidermis was obtained in vitro by culturing second-passage normal human keratinocytes (NHK) in the chemically defined medium MCDB 153 on inert filter substrates at the air-liquid interface for 14 d. Vertical sections stained for histology and indirect immunofluorescence studies show a correct stratification and expression of differentiation markers. The presence of desmosomes, keratohyalin granules, and lamellar granules, and the formation of a more than ten-layers stratum corneum was evidenced by electron microscopy. Moreover, lipids typical for differentiated epidermis were present in these cultures, including ceramides, which are thought to be responsible for the relative impermeability of the stratum corneum. Under our culture conditions, i.e., in defined medium and at the air-liquid interface, the use of de-epidermized dermis as a substrate did not stimulate keratinocyte differentiation more than acetate cellulose or poly-carbonate filter membrane substrates.The obtaining of a well-differentiated epidermis grown in vitro on inert filters in a chemically defined medium should be useful as a standard system for studying epidermal differentiation, re-epidermization, cytotoxicity, epidermal permeation, and transepidermal drug delivery

PEMBUATAN DAN PENGUJIAN PERANGKAT LUNAK SISTEM PENCEGAH POTENSI KEBAKARAN BERDASARKAN DETEKSI KEBOCORAN GAS DAN SUHU RUANGAN UNTUK RUMAH TINGGAL MELALUI ALARM

Kebakaran adalah peristiwa atau kejadian timbulnya api yang tidak terkendali yang dapat membahayakan keselamatan jiwa maupun harta benda. Salah satu penyebab terjadinya kebakaran tersebut adalah kebocoran gas LPG. Penelitian ini bertujuan untuk merancang sistem perangkat lunak deteksi kebocoran gas rumah tangga untuk mengurangi potensi terjadinya kebakaran di rumah tangga khususnya di ruangan dapur. Metode penulisan ini adalah melihat langsung ke lapangan untuk mengumpulkan data. Metode ini berbasis Microcontroler ATMega 16 dan menggunakan software CVAVR. Hasil dari pembuatan alat tersebut adalah alat tersebut dapat mendeteksi kebocoran gas dan suhu asap apabila pada ruangan tersebut memiliki sensor asap dan sensor suhu panas diatas 50o C, sehingga dapat meminimalisir resiko yang akan terjadi apabila terdapat kebocoran gas pada rumah tinggal. The fire is event or occurrence for an uncontrolled fire that could endanger and wealth. One of the cause of the incident was a gas leak LPG tube one. This stude attemps to design systems software detection gas leak house holds in order to reduce the potential for fire at households especiallu in a room. A method of writing this actually looking at the field to collect data. This method base microcontroller ATMega 16 and use software CVAvr. The result of making the device is the devices could detect gas leak and temperature smoke. If the room has sensors smoke and censorship heat up 50o , so as to minimalize of the risk of what will happen if there was a gas leak on houses

Pengaruh Intellectual Capital dan Likuiditas terhadap Nilai Perusahaan pada Perusahaan Industri Makanan dan Minuman yang Terdaftar di Bursa Efek Indonesia

This study aims to determine the effect of intellectual capital and liquidity on company value in food and beverage industry companies listed on the Indonesia Stock Exchange with a research period of 2018-2021. The data used is secondary data. The population in this study are food and beverage industry companies listed on the Indonesia Stock Exchange. The sampling technique used was purposive sampling method and 18 companies were obtained with a total of 72 samples. Hypothesis testing was carried out by means of multiple linear regression analysis. The results showed that intellectual capital has an effect on firm value and liquidity has no effect on firm value

Uncovering pedagogical gaps in a chemistry classroom: Implications for teaching and learning

This study was carried out to uncover the pedagogical gaps by characterizing the teaching practices of chemistry within a teacher education institution and subsequently, identifying the prevalent, non-prevalent and unobserved teaching practices. Accordingly, this implementation study employed the classroom observation method. The one-semester implementation of 11 chemistry lessons of a university lecturer was observed using a psychometrically-validated observation checklist comprises 50 items or indicators that measure six principles (dimensions). The use of the observation checklist entails checking whether each indicator is observed or otherwise during classroom observations. With a frequency of more than 25% to be considered prevalent, the findings indicate that the lecturer prevalently “maintained a scaffolding of instructional alignment” (62.5%), “offered quality learning environments, resources, and technology” (57.1%), and “promoted positive beliefs, attitudes, and behavioral patterns” (54.5%). However, it was a non-prevalent practice in “encouraging intellectual curiosity” (8.3%), and “promoting an atmosphere of critical thinking and inquiry” (14.3%). The practice of “offering a varied learning atmosphere” was, regrettably, non-existent (0%). The pedagogical gaps uncovered are discussed in terms of the needed customized staff development on teaching and learning in teacher education, particularly the content coverage of pedagogy (or teaching models), and the pedagogical coverage of pedagogy

Perceived sources of stress among Malaysian dental students

Objectives: The study objectives were to identify the stress levels and to explore the impact of students’ year of study and gender on the perceived sources of stress among Malaysian dental students. Methods: This was a cross-sectional study involving dental students from year one to year five from private and public universities in Malaysia. The study was formally approved by the Research and Ethics Committee, International Medical University Malaysia. Dental Environment Stress (DES) questionnaire was used for data collection and the gathered data were analyzed using SPSS® version 18. The Kruskal-Wallis and the Mann-Whitney U tests were used to compare stress items across various academic years and universities. Results: A total of five hundred and twenty nine (529) students participated in this study. Fear of failing the course at the end of year exams (mean stress level=5.57); concerns regarding completion of clinical work (mean=5.30); and examination results and grades (mean=5.27) were found as top stressors among dental students. Female students had higher stress scores than males with respect to personal issues, academic performance, educational environment and learning of clinical skills. Students from public universities had higher stress scores than their counterparts from private universities. Conclusion: The Malaysian dental students reported higher levels of stress. Present study identified stressors affecting dental students’ academic life, and highlights the importance of stress management programs and other measures to minimize the impact of stress on both academic and personal lives of the students

Aloe emodin induces apoptosis in ER+-breast cancer cells; MCF-7 through IGF-1R signalling pathway

Two-third of breast cancer patients expressed estrogen receptors (ER)s and received endocrine treatment with established anti-estrogens such as tamoxifen. But the action and acquired resistance during treatment are largely unknown. In contrary, phytochemicals are more selective and less cytotoxic to normal cells. Accordingly, we found aloe emodin, an anthraquinone to inhibit the proliferation of ER+-breast cancer cells, MCF-7 with IC50 of 80 μM, but not affecting control breast cells, MCF-10A. Tamoxifen was non-selective to both cells with IC50 of 27 and 38 μM, respectively. Thus, we aimed to investigate the anti-proliferative mechanism of aloe emodin on MCF-7 and its underlying signalling compared to tamoxifen. Cells were treated separately with aloe emodin and tamoxifen at respective IC50 for 72 h. Apoptosis was determined using Annexin V-FITC/PI staining. The expression of insulin-like growth factor-1 receptor (IGF-1R), insulin-like growth factor binding protein (IGFBP)-2 and B-raf gene was investigated using QuantiGene 2.0 Plex assay. Paired-student t-test and ANOVA test were used to compare between untreated and treated cells on the measured parameters. Each treatment was conducted in triplicate and repeated three times. Significance was set at p<0.05. The presences of early and late apoptosis in MCF-7 were seen in both treatments. All target genes were down regulated. The anti-proliferation effect of aloe emodin on MCF-7 is similar with tamoxifen which mediates inhibition of IGF-1R signalling pathway. This suggests aloe emodin as a potential anti-cancer agent to be used in combined anti-estrogen therapy to enhance its efficacy in ER+-breast cancer treatment

Family Functioning and Social Life Regulation among Adolescents

&nbsp;Family is the smallest unit in the community which has a big influence in adolescents’ growth. The study determined the relationship of family functioning and social life regulation among adolescents. The variables considered on family functioning are: Affective responses, communication, family roles, and problem solving. The respondents were 216 adolescents, ages 16-21 years old that were selected using convenient sampling technique. The respondents answered questionnaires to measure family functioning and social life regulation. The result indicated a significant positive relationship between family functioning specifically on communication, family roles, and problem solving to social life regulation. This suggests that the more open the adolescents are with their family, the clearer their roles are in their family. Moreover, the more able the family is in solving problems, the higher the adolescents’ are capable in relating positively with their peers and balancing social life between their family and peers.&nbsp

Tapasztalatok a levetiracetamkezeléssel gyermekkori epilepsziákban = Experience with levetiracetam in childhood epilepsy

OBJECTIVE: To evaluate the efficacy and tolerability of levetiracetam in children with drug resistant epilepsy from a retrospective study. METHODS: We report the result of a study of 85 pediatric patients (mean 10.5 years, range: 1-24) with refractory generalized and focal epilepsy, who received levetiracetam as add-on treatment. The average duration of epilepsy was eight years, and the patient were treated with mean of 6.0 antiepileptic drugs before levetiracetam was introduced. RESULTS: Ten patients (12%) became seizure-free, three (3%) responded with seizure reduction of more than 90%, 32 (38%) responded with seizure reduction of more than 50% following introduction of levetiracetam. No response to levetiracetam was reported in 34% (n: 29). Positive psychotropic effect was observed in 26 patient (30%). Mild to moderate side effects were reported in 11 patients (13%), consisting most frequently general behavioral changes, aggression, sleep disturbances, but they ceased after decreasing the dose of levetiracetam. Mental retardation was associated with poor response and associated with more side effects. CONCLUSION: Levetiracetam is a well tolerated new antiepileptic drug that may effectively improve seizures control as an add-on drug in resistant epilepsy in childhood with good tolerability