Il ruolo dell’Architettura nella gestione dei Commons: un’ipotesi per lo “Scugnizzo liberato”.

Nel 2013 il Comune di Napoli ha istituito l’Osservatorio sui beni comuni, con quest’atto viene ufficializzata una posizione innovativa, ma anche fortemente controversa, relativa alla gestione di beni di proprietà pubblica o privata da parte di “comunità” che utilizzano questi spazi realizzando un utile sociale. Il numero di Louts del 1994 dal titolo Commons traccia la relazione tra questa questione, di natura economica, politica e sociale e l’architettura. In particolare a Napoli i nove spazi individuati dall’Osservatorio pongono agli architetti nuove domande e, prima tra tutte, come conciliare questa modalità di gestione dal basso, che ha sicuramente il merito di restituire alla comunità luoghi spesso dimenticati e abbandonati, con le esigenze di tutela e conservazione del patrimonio culturale della città. Partendo dal caso dello” scugnizzo liberato” l'intervento proverà a definire un possibile ruolo dell’architettura nel processo di gestione dei Commons

The Role of Distributed Computing in Big Data Science: Case Studies in Forensics and Bioinformatics

2014 - 2015The era of Big Data is leading the generation of large amounts of data, which require storage and analysis capabilities that can be only ad- dressed by distributed computing systems. To facilitate large-scale distributed computing, many programming paradigms and frame- works have been proposed, such as MapReduce and Apache Hadoop, which transparently address some issues of distributed systems and hide most of their technical details. Hadoop is currently the most popular and mature framework sup- porting the MapReduce paradigm, and it is widely used to store and process Big Data using a cluster of computers. The solutions such as Hadoop are attractive, since they simplify the transformation of an application from non-parallel to the distributed one by means of general utilities and without many skills. However, without any algorithm engineering activity, some target applications are not alto- gether fast and e cient, and they can su er from several problems and drawbacks when are executed on a distributed system. In fact, a distributed implementation is a necessary but not su cient condition to obtain remarkable performance with respect to a non-parallel coun- terpart. Therefore, it is required to assess how distributed solutions are run on a Hadoop cluster, and/or how their performance can be improved to reduce resources consumption and completion times. In this dissertation, we will show how Hadoop-based implementations can be enhanced by using carefully algorithm engineering activity, tuning, pro ling and code improvements. It is also analyzed how to achieve these goals by working on some critical points, such as: data local computation, input split size, number and granularity of tasks, cluster con guration, input/output representation, etc. i In particular, to address these issues, we choose some case studies coming from two research areas where the amount of data is rapidly increasing, namely, Digital Image Forensics and Bioinformatics. We mainly describe full- edged implementations to show how to design, engineer, improve and evaluate Hadoop-based solutions for Source Camera Identi cation problem, i.e., recognizing the camera used for taking a given digital image, adopting the algorithm by Fridrich et al., and for two of the main problems in Bioinformatics, i.e., alignment- free sequence comparison and extraction of k-mer cumulative or local statistics. The results achieved by our improved implementations show that they are substantially faster than the non-parallel counterparts, and re- markably faster than the corresponding Hadoop-based naive imple- mentations. In some cases, for example, our solution for k-mer statis- tics is approximately 30× faster than our Hadoop-based naive im- plementation, and about 40× faster than an analogous tool build on Hadoop. In addition, our applications are also scalable, i.e., execution times are (approximately) halved by doubling the computing units. Indeed, algorithm engineering activities based on the implementation of smart improvements and supported by careful pro ling and tun- ing may lead to a much better experimental performance avoiding potential problems. We also highlight how the proposed solutions, tips, tricks and insights can be used in other research areas and problems. Although Hadoop simpli es some tasks of the distributed environ- ments, we must thoroughly know it to achieve remarkable perfor- mance. It is not enough to be an expert of the application domain to build Hadop-based implementations, indeed, in order to achieve good performance, an expert of distributed systems, algorithm engi- neering, tuning, pro ling, etc. is also required. Therefore, the best performance depend heavily on the cooperation degree between the domain expert and the distributed algorithm engineer. [edited by Author]XIV n.s

Parent Perceptions of How Nurse Encounters Can Provide Caring Support for the Family in Early Acute Care After Children’s Severe Traumatic Brain Injury

A child’s severe traumatic brain injury (TBI) creates a family crisis requiring extensive cultural, informational, psychological, and environmental support. Nurses need to understand parents’ expectations of caring in early acute care so they can tailor their attitudes, beliefs, and behaviors appropriately to accommodate the family’s needs

Challenging Nurses’ Cultural Competence of Disability to Improve Interpersonal Interactions

Worldwide, at least 6.9 billion people have an impairment producing health condition (IPHC). Insensitive encounters with health care providers (HCPs) can result in negative appraisals, fear, and avoidance, but little is known about what things are commonly perceived as insensitive. A review of published narratives describing negative encounters with HCPs was conducted. Narrative analysis was used to compare, contrast, and synthesize six themes describing the common negative encounters: (a) ignoring or minimizing their knowledge; (b) detached interpersonal interactions; (c) placing a negative skew on their life quality; (d) a lack of HCP knowledge related to their complete needs; (e) assuming they should be asexual and childless; and, (f) an inherent power differential. The medical model of disability is perceived by individuals with IPHCs to inform negative encounters perceived as insensitive. This preliminary knowledge is important so we can address education needs, plan future research questions, and establish clinical practice improvements

Nuovo metodo di preparazione di coloranti naturali

The present invention relates to a new method of preparing a colouring mixture, to the colouring mixture obtainable by this method and to the uses thereof. The method and the products of the invention are used in the natural dyeing of animal fibres, plant fibres, hides, paper and other products

Identification of two distinct intron elements involved in alternative splicing of beta-tropomyosin pre-mRNA

The rat beta-tropomyosin gene encodes two isoforms, termed skeletal muscle beta-tropomyosin and fibroblast last tropomyosim 1 (TM-1), via an alternative RNA processing mechanism. The gene contains 11 exons. Exons 1-5 and exons 8 and 9 are common to all mRNAs expressed from the gene. Exons 6 and 11 are used in fibroblasts, as well as smooth muscle, whereas exons 7 and 10 are used only in skeletal muscle. In the present studies we focused on the mutually exclusive internal alternative splice choice involving exon 6 (fibroblast-type splice) and exon 7 (skeletal muscle-type splice). We have identified two distinct elements in the intron, upstream of exon 7, involved in splice site selection. The first element is comprised of a polypyrimidine tract located 89-143 nucleotides upstream of the 3' splice site, which specifies the location of the lariat branchpoints used, 144-153 nucleotides upstream of exon 7. The 3' splice site AG dinucleotide has no role in selection of these branchpoints. The second element is comprised of intron sequences located between the polypyrimidine tract and the 3' splice site of exon 7. It contains an important determinant in alternative splice site selection, because deletion of these sequences results in the use of the skeletal muscle-specific exon in nonmuscle cells. We propose that the use of lariat branchpoints located far upstream from a 3' splice site may be a general feature of some alternatively excised introns, reflecting the presence of regulatory sequences located between the lariat branch site and the 3' splice site. The data also indicate that alternative splicing of the rat beta-tropomyosin gene is regulated by a somewhat different mechanism from that described for rat alpha-tropomyosin gene and the transformer-2 gene of Drosophila melanogaster

Physicochemical properties of mixed micellar aggregates containing CCK peptides and Gd complexes designed as tumor specific contrast agents in MRI

New amphiphilic molecules containing a bioactive peptide or a claw moiety have been prepared in order to obtain mixed micelles as target-specific contrast agents in magnetic resonance imaging. The first molecule, C18H37CONH(AdOO)2-G-CCK8 (C18CCK8), contains a C18 hydrophobic moiety bound to the C-terminal cholecystokinin octapeptide amide (CCK 26-33 or CCK8). The second amphiphilic compound, C18H37CONHLys(DTPAGlu)CONH2 (C18DTPAGlu) or its gadolinium complex, (C18DTPAGlu- (Gd)), contains the same C18 hydrophobic moiety bound, through a lysine residue, to the DTPAGlu chelating agent. The mixed aggregates as well as the pure C18DTPAGlu aggregate, in the presence and absence of Gd, have been fully characterized by surface tension measurements, FT-PGSE-NMR, fluorescence quenching, and small-angle neutron scattering measurements. The structural characterization of the mixed aggregates C18DTPAGlu(Gd)-C18CCK8 indicates a spherical arrangement of the micelles with an external shell of 21 Å and an inner core of 20 Å. Both the DTPAGlu(Gd) complexes and the CCK8 peptides point toward the external surface. The measured values for relaxivity in saline medium at 20 MHz proton Larmor frequency and 25 °C are 18.7 mM-1 s-1. These values show a large enhancement in comparison with the isolated DTPAGlu(Gd) complex