Not Available

Not AvailableThe 'Farmer FIRST Programme’ was a unique initiative of Indian Council of Agricultural Research (ICAR) that focussed on farmers’ Farm, Innovations, Resources, Science and Technology (FIRST) where farmers played centric role for research problem identification, prioritization and conduct of experiments and its management in field conditions. The major target groups were small and marginal farmers including women. The problems of farmers related to agricultural production were discussed in details in farmer-scientist interface and those problems were addressed with best suitable interventions covered under different modules. Organizing training programmes/exposure visits for farmers to enrich technical knowledge; supplying superior quality germplasm of various crops/livestock/poultry strains/fishes; using soil test-based fertilizers; managing nutrients through leaf colour chart; practising line transplanting in paddy; using mulching for soil moisture conservation; using poly house technology; adopting sprinkler/drip irrigation; using trellis system in horticultural crops production; managing crops, livestock, poultry and fishes scientifically; selecting appropriate enterprises, establishing marketing channels for agricultural produces were among the major interventions adopted under this programme. As a result, agricultural production was increased substantially under crop- and horticulture-based module (both varied from 20-200%), natural resource management module (ranged between 12 and 100%), livestock module (varied from 15-150%), enterprise-based module (ranged from 12-100%) and integrated farming system-based module (ranged between 14 and 200%) which fetched higher income to the farmers than before adopting interventions.Not Availabl

A LOFAR prompt search for radio emission accompanying X-ray flares in GRB 210112A

© The Author(s) 2023. Published by Oxford University Press on behalf of Royal Astronomical Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).The composition of relativistic gamma-ray burst (GRB) jets and their emission mechanisms are still debated, and they could be matter or magnetically dominated. One way to distinguish these mechanisms arises because a Poynting flux dominated jet may produce low-frequency radio emission during the energetic prompt phase, through magnetic reconnection at the shock front. We present a search for radio emission coincident with three GRB X-ray flares with the LOw Frequency ARray (LOFAR), in a rapid response mode follow-up of long GRB 210112A (at z~2) with a 2 hour duration, where our observations began 511 seconds after the initial swift-BAT trigger. Using timesliced imaging at 120-168 MHz, we obtain upper limits at 3 sigma confidence of 42 mJy averaging over 320 second snapshot images, and 87 mJy averaging over 60 second snapshot images. LOFAR's fast response time means that all three potential radio counterparts to X-ray flares are observable after accounting for dispersion at the estimated source redshift. Furthermore, the radio pulse in the magnetic wind model was expected to be detectable at our observing frequency and flux density limits which allows us to disfavour a region of parameter space for this GRB. However, we note that stricter constraints on redshift and the fraction of energy in the magnetic field are required to further test jet characteristics across the GRB population.Peer reviewe

The long-active afterglow of GRB 210204A: detection of the most delayed flares in a gamma-ray burst

We present results from extensive broadband follow-up of GRB 210204A over the period of 30 d. We detect optical flares in the afterglow at 7.6 × 105 s and 1.1 × 106 s after the burst: the most delayed flaring ever detected in a GRB afterglow. At the source redshift of 0.876, the rest-frame delay is 5.8 × 105 s (6.71 d). We investigate possible causes for this flaring and conclude that the most likely cause is a refreshed shock in the jet. The prompt emission of the GRB is within the range of typical long bursts: it shows three disjoint emission episodes, which all follow the typical GRB correlations. This suggests that GRB 210204A might not have any special properties that caused late-time flaring, and the lack of such detections for other afterglows might be resulting from the paucity of late-time observations. Systematic late-time follow-up of a larger sample of GRBs can shed more light on such afterglow behaviour. Further analysis of the GRB 210204A shows that the late-time bump in the light curve is highly unlikely due to underlying SNe at redshift (z) = 0.876 and is more likely due to the late-time flaring activity. The cause of this variability is not clearly quantifiable due to the lack of multiband data at late-time constraints by bad weather conditions. The flare of GRB 210204A is the latest flare detected to date

The combination of the PARP inhibitor rucaparib and 5FU is an effective strategy for treating acute leukemias

The existing treatments to cure acute leukemias seem to be non-specific and suboptimal for most patients, drawing attention to the need of new therapeutic strategies. In the last decade the anticancer potential of poly ADP-ribose polymerase (PARP) inhibitors became apparent and now several PARP inhibitors are being developed to treat various malignancies. So far the usage of PARP inhibitors has been mainly focused on the treatment of solid tumors and not too much about its efficacy on leukemias is known. In this study we test, for the first time on leukemic cells, a combined therapy that associates the conventional chemotherapeutic agent fluorouracil (5FU), used as a source of DNA damage, and a PARP inhibitor, rucaparib. We demonstrate the efficacy and the specificity of this combined therapy in killing both acute myeloid leukemia and acute lymphoid leukemia cells in vitro and in vivo. We clearly show that the inhibition of DNA repair induced by rucaparib is synthetic lethal with the DNA damage caused by 5FU in leukemic cells. Therefore, we propose a new therapeutic strategy able to enhance the cytotoxic effect of DNA-damaging agents in leukemia cells via inhibiting the repair of damaged DNA

A LOFAR prompt search for radio emission accompanying X-ray flares in GRB 210112A

The composition of relativistic gamma-ray burst (GRB) jets and their emission mechanisms are still debated, and they could be matter or magnetically dominated. One way to distinguish these mechanisms arises because a Poynting flux dominated jet may produce low-frequency radio emission during the energetic prompt phase, through magnetic reconnection at the shock front. We present a search for radio emission coincident with three GRB X-ray flares with the LOw Frequency ARray (LOFAR), in a rapid response mode follow-up of long GRB 210112A (at z ∼ 2) with a 2 h duration, where our observations began 511 s after the initial Swift-BAT trigger. Using time-sliced imaging at 120–168 MHz, we obtain upper limits at 3σ confidence of 42 mJy averaging over 320 s snapshot images, and 87 mJy averaging over 60 s snapshot images. LOFAR’s fast response time means that all three potential radio counterparts to X-ray flares are observable after accounting for dispersion at the estimated source redshift. Furthermore, the radio pulse in the magnetic wind model was expected to be detectable at our observing frequency and flux density limits which allows us to disfavour a region of parameter space for this GRB. However, we note that stricter constraints on redshift and the fraction of energy in the magnetic field are required to further test jet characteristics across the GRB population.</p