Up in the Air Over Taxing Frequent Flyer Benefits: The American, Canadian, and Australian Experiences

Vessel segmentation is an important prerequisite for many medical applications. While automatic vessel segmentation is an active field of research, interaction and visualization techniques for semi-automatic solutions have gotten far less attention. Nevertheless, since automatic techniques do not generally achieve perfect results, interaction is necessary. Especially for tasks that require an in-detail inspection or analysis of the shape of vascular structures precise segmentations are essential. However, in many cases these can only be generated by incorporating expert knowledge. In this paper we propose a visual vessel segmentation system that allows the user to interactively generate vessel segmentations. Therefore, we employ multiple linked views which allow to assess different aspects of the segmentation and depict its different quality metrics. Based on these quality metrics, the user is guided, can assess the segmentation quality in detail and modify the segmentation accordingly. One common modification is the editing of branches, for which we propose a semi-automatic sketch-based interaction metaphor. Additionally, the user can also influence the shape of the vessel wall or the centerline through sketching. To assess the value of our system we discuss feedback from medical experts and have performed a thorough evaluation

Total Denoising: Unsupervised Learning of 3D Point Cloud Cleaning

We show that denoising of 3D point clouds can be learned unsupervised, directly from noisy 3D point cloud data only. This is achieved by extending recent ideas from learning of unsupervised image denoisers to unstructured 3D point clouds. Unsupervised image denoisers operate under the assumption that a noisy pixel observation is a random realization of a distribution around a clean pixel value, which allows appropriate learning on this distribution to eventually converge to the correct value. Regrettably, this assumption is not valid for unstructured points: 3D point clouds are subject to total noise, i. e., deviations in all coordinates, with no reliable pixel grid. Thus, an observation can be the realization of an entire manifold of clean 3D points, which makes a na\"ive extension of unsupervised image denoisers to 3D point clouds impractical. Overcoming this, we introduce a spatial prior term, that steers converges to the unique closest out of the many possible modes on a manifold. Our results demonstrate unsupervised denoising performance similar to that of supervised learning with clean data when given enough training examples - whereby we do not need any pairs of noisy and clean training data.Comment: Proceedings of ICCV 201

Single-image Tomography: 3D Volumes from 2D Cranial X-Rays

As many different 3D volumes could produce the same 2D x-ray image, inverting this process is challenging. We show that recent deep learning-based convolutional neural networks can solve this task. As the main challenge in learning is the sheer amount of data created when extending the 2D image into a 3D volume, we suggest firstly to learn a coarse, fixed-resolution volume which is then fused in a second step with the input x-ray into a high-resolution volume. To train and validate our approach we introduce a new dataset that comprises of close to half a million computer-simulated 2D x-ray images of 3D volumes scanned from 175 mammalian species. Applications of our approach include stereoscopic rendering of legacy x-ray images, re-rendering of x-rays including changes of illumination, view pose or geometry. Our evaluation includes comparison to previous tomography work, previous learning methods using our data, a user study and application to a set of real x-rays

Leveraging Self-Supervised Vision Transformers for Neural Transfer Function Design

In volume rendering, transfer functions are used to classify structures of interest, and to assign optical properties such as color and opacity. They are commonly defined as 1D or 2D functions that map simple features to these optical properties. As the process of designing a transfer function is typically tedious and unintuitive, several approaches have been proposed for their interactive specification. In this paper, we present a novel method to define transfer functions for volume rendering by leveraging the feature extraction capabilities of self-supervised pre-trained vision transformers. To design a transfer function, users simply select the structures of interest in a slice viewer, and our method automatically selects similar structures based on the high-level features extracted by the neural network. Contrary to previous learning-based transfer function approaches, our method does not require training of models and allows for quick inference, enabling an interactive exploration of the volume data. Our approach reduces the amount of necessary annotations by interactively informing the user about the current classification, so they can focus on annotating the structures of interest that still require annotation. In practice, this allows users to design transfer functions within seconds, instead of minutes. We compare our method to existing learning-based approaches in terms of annotation and compute time, as well as with respect to segmentation accuracy. Our accompanying video showcases the interactivity and effectiveness of our method

exploRNN: Understanding Recurrent Neural Networks through Visual Exploration

Due to the success of deep learning and its growing job market, students and researchers from many areas are getting interested in learning about deep learning technologies. Visualization has proven to be of great help during this learning process, while most current educational visualizations are targeted towards one specific architecture or use case. Unfortunately, recurrent neural networks (RNNs), which are capable of processing sequential data, are not covered yet, despite the fact that tasks on sequential data, such as text and function analysis, are at the forefront of deep learning research. Therefore, we propose exploRNN, the first interactively explorable, educational visualization for RNNs. exploRNN allows for interactive experimentation with RNNs, and provides in-depth information on their functionality and behavior during training. By defining educational objectives targeted towards understanding RNNs, and using these as guidelines throughout the visual design process, we have designed exploRNN to communicate the most important concepts of RNNs directly within a web browser. By means of exploRNN, we provide an overview of the training process of RNNs at a coarse level, while also allowing detailed inspection of the data-flow within LSTM cells. Within this paper, we motivate our design of exploRNN, detail its realization, and discuss the results of a user study investigating the benefits of exploRNN

Physics-based visual characterization of molecular interaction forces

Molecular simulations are used in many areas of biotechnology, such as drug design and enzyme engineering. Despite the development of automatic computational protocols, analysis of molecular interactions is still a major aspect where human comprehension and intuition are key to accelerate, analyze, and propose modifications to the molecule of interest. Most visualization algorithms help the users by providing an accurate depiction of the spatial arrangement: the atoms involved in inter-molecular contacts. There are few tools that provide visual information on the forces governing molecular docking. However, these tools, commonly restricted to close interaction between atoms, do not consider whole simulation paths, long-range distances and, importantly, do not provide visual cues for a quick and intuitive comprehension of the energy functions (modeling intermolecular interactions) involved. In this paper, we propose visualizations designed to enable the characterization of interaction forces by taking into account several relevant variables such as molecule-ligand distance and the energy function, which is essential to understand binding affinities. We put emphasis on mapping molecular docking paths obtained from Molecular Dynamics or Monte Carlo simulations, and provide time-dependent visualizations for different energy components and particle resolutions: atoms, groups or residues. The presented visualizations have the potential to support domain experts in a more efficient drug or enzyme design process.Peer ReviewedPostprint (author's final draft