Fibroblast involvement in soft connective tissue calcification

Soft connective tissue calcification is not a passive process, but the consequence of metabolic changes of local mesenchymal cells that, depending on both genetic and environmental factors, alter the balance between pro- and anti-calcifying pathways. While the role of smooth muscle cells and pericytes in ectopic calcifications has been widely investigated, the involvement of fibroblasts is still elusive. Fibroblasts isolated from the dermis of pseudoxanthoma elasticum (PXE) patients and of patients exhibiting PXE-like clinical and histopathological findings offer an attractive model to investigate the mechanisms leading to the precipitation of mineral deposits within elastic fibers and to explore the influence of the genetic background and of the extracellular environment on fibroblast-associated calcifications, thus improving the knowledge on the role of mesenchymal cells on pathologic mineralizatio

Enhancing L2 skills through independent learning: the case study of Italian e-magazine

Engaging students in the learning process of a second language can be challenging and the tutor always needs to find new tools to enhance motivation for learner engagement in and outside the classroom. Starting from our linguistic and journalistic background, we started to create an e-magazine in Italian language (dealing with Italian topics, current affairs in Italy, etc.) with the active involvement of the Italian class students from Upper Intermediate to Proficiency level (B1 to C2). The Italian e-magazine is created within the Department of Languages at Leeds Beckett University to allow students to develop academic skills and to embrace a topic-based linguistic challenge of authentic materials. The students have been deeply engaged in research, reading, discussion and writing in Italian and the results of this experiment have been significantly impactful. The practice of the four skills has resulted in an enrichment of the vocabulary, a development of accuracy and the creation of group works with exchange of opinions. The experience has shown how the flipped classroom experience and the independent learning can interchangeably inform each other. All these activities led to: • Developing motivation • Stimulating interest and curiosity • Engagement in research • Flipped learning Students became active participants in planning and delivering learning activities. They have developed and produced tools in a learner-centred approach, showing a great interest in the idea and a significant improvement in their learning process. “The important practical contribution of the students represents the strength of their engagement in the study of the target language and the involvement in writing as a tool for learning and development” (Ferris D., 2008). It has become clear that this project is going to grow more and more thanks to the enthusiasm of our learners and the support in the group work

Cannula tip intravascular migration in an infant

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Polarization observables in high-energy deuteron photodisintegration within the Quark-Gluon Strings Model

Deuteron two-body photodisintegration is analysed within the framework of the Quark-Gluon Strings Model. The model describes fairly well the recent experimental data from TJNAF in the few GeV region. Angular distributions at different $\gamma$-energies are presented and the effect of a forward-backward asymmetry is discussed. New results from the QGSM for polarization observables from 1.5 -- 6 GeV are presented and compared with the available data.Comment: 3 pages, LaTeX, 4 postscript figures; contribution to QNP2002, Juelich, June 10-14, 200

Estimating mass-wasting processes in active earth slides – earth flows with time-series of High-Resolution DEMs from photogrammetry and airborne LiDAR

Abstract. This paper deals with the use of time-series of High-Resolution Digital Elevation Models (HR DEMs) obtained from photogrammetry and airborne LiDAR coupled with aerial photos, to analyse the magnitude of recently reactivated large scale earth slides – earth flows located in the northern Apennines of Italy. The landslides underwent complete reactivation between 2001 and 2006, causing civil protection emergencies. With the final aim to support hazard assessment and the planning of mitigation measures, high-resolution DEMs are used to identify, quantify and visualize depletion and accumulation in the slope resulting from the reactivation of the mass movements. This information allows to quantify mass wasting, i.e. the amount of landslide material that is wasted during reactivation events due to stream erosion along the slope and at its bottom, resulting in sediment discharge into the local fluvial system, and to assess the total volumetric magnitude of the events. By quantifying and visualising elevation changes at the slope scale, results are also a valuable support for the comprehension of geomorphological processes acting behind the evolution of the analysed landslides

Self-Diffusion in Random-Tiling Quasicrystals

The first explicit realization of the conjecture that phason dynamics leads to self-diffusion in quasicrystals is presented for the icosahedral Ammann tilings. On short time scales, the transport is found to be subdiffusive with the exponent $\beta\approx0.57(1)$, while on long time scales it is consistent with normal diffusion that is up to an order of magnitude larger than in the typical room temperature vacancy-assisted self-diffusion. No simple finite-size scaling is found, suggesting anomalous corrections to normal diffusion, or existence of at least two independent length scales.Comment: 11 pages + 2 figures, COMPRESSED postscript figures available by anonymous ftp to black_hole.physics.ubc.ca directory outgoing/diffuse (use bi for binary mode to transfer), REVTeX 3.0, CTP-TAMU 21/9

Antibacterial β-Glucan/Zinc Oxide Nanocomposite Films for Wound Healing

Advanced antimicrobial biomaterials for wound healing applications are an active field of research for their potential in addressing severe and infected wounds and overcoming the threat of antimicrobial resistance. Beta-glucans have been used in the preparation of these materials for their bioactive properties, but very little progress has been made so far in producing biomedical devices entirely made of beta-glucans and in their integration with effective antimicrobial agents. In this work, a simple and eco-friendly method is used to produce flexible beta-glucan/nanostructured zinc oxide films, using glucans derived from the yeast Saccharomyces cerevisiae. The properties of the films are characterized through scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy, X-ray diffraction, infrared and UV–visible spectroscopy, thermogravimetric analysis, differential scanning calorimetry, and water absorption tests. Finally, the antibacterial properties of the nanostructured zinc oxide and of the composite films are assessed against Staphylococcus epidermidis and Escherichia coli, showing a marked effectiveness against the former. Overall, this study demonstrates how a novel bionanocomposite can be obtained towards the development of advanced wound healing devices

Editorial: Congenital and perinatal infections: How to prevent sequelaes in neonates and children

The current severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has overwhelmingly absorbed attention and health resources for 2 years, allowing us to reflect that infections are a permanent health and social problem, causing morbidity and mortality. They require organization, important prevention measures, and containment. This is particularly true in the neonatal age, where infections remain a complex problem with serious consequences

LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems?

Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) reported to be frequently deregulated in various types of cancers and neurodegenerative processes. NEAT1 is an indispensable structural component of paraspeckles (PSs), which are dynamic and membraneless nuclear bodies that affect different cellular functions, including stress response. Furthermore, increasing evidence supports the crucial role of NEAT1 and essential structural proteins of PSs (PSPs) in the regulation of the DNA damage repair (DDR) system. This review aims to provide an overview of the current knowledge on the involvement of NEAT1 and PSPs in DDR, which might strengthen the rationale underlying future NEAT1-based therapeutic options in tumor and neurodegenerative diseases

Lidar And Hyperspectral Data Integration For Landslide Monitoring: The Test Case Of Valoria Landslide

In the framework of the WISELAND project, funded by MIUR, we tested the integration between Lidar and hyperspectral methodologies in the Valoria landslide (Modena province, Italy), a high risk area with vulnerable elements, subjected to periodic and abrupt reactivations. Multitemporal Lidar Digital Terrain Models (DTMs) allowed the calculation of a differential surface, highlighting absolute height variations, recognizing the main landslide components and identifying depletion and accumulation zones. Hyperspectral data helped in the landslide terrain roughness characterization, performing the Principal Component Analysis (PCA) and correlating the results with Flatness and Organization geomorphometric parameters derived from Lidar DTM