Gestão pública em redes e a nova governança pública: a implementação de parcerias entre o poder público e o terceiro setor

As pesquisas dentro da administração pública tem dado cada vez mais atenção ao terceiro setor e sobre seu papel e importância na provisão de serviços públicos. Diante da escassez de recursos e das dificuldades vividas pelo Estado em atender todas as demandas dos cidadãos, tem sido prática comum o estabelecimento de parcerias entre o poder público e o terceiro setor. O movimento da Nova Governança Pública tem como um de seus objetos de estudo a entrega interorganizacional de serviços públicos e a implementação de políticas públicas em rede. O presente estudo buscou verificar os resultados práticos obtidos através da implementação de uma parceria entre a Secretaria de Esportes, Lazer e Recreação da Prefeitura de São Paulo (poder público) e o Instituto César Cielo (terceiro setor), que tinha como objetivo potencializar o trabalho realizado na modalidade de natação do Centro Olímpico de Treinamento e Pesquisa. A metodologia utilizada foi a do estudo de caso, através de uma triangulação dos dados obtidos de entrevistas semi-estruturadas, documentos oficiais e publicações na imprensa especializada. Os resultados obtidos mostraram que a parceria foi positiva, gerando melhores resultados para a modalidade, o que demonstra a importância de ações integradas entre poder público e terceiro setor

DESEMPENHO DE CULTIVARES DE ALFACE CRESPA PRODUZIDAS EM HIDROPONIA A PARTIR DE MUDAS PRODUZIDAS EM FLOATING E ESPUMA FENÓLICA.

Objetivando-se avaliar o desempenho de cultivares de alface crespa produzidas em hidroponia a partir de mudas produzidas em floating e espuma fenólica, realizou-se um experimento em casa de vegetação, na Fazenda Experimental da Universidade de Marília-SP. O delineamento experimental adotado foi o inteiramente casualizado em esquema fatorial 2 x 2, com cinco repetições, cujos fatores corresponderam respectivamente, a dois sistemas de cultivo para a produção de mudas (floating e espuma fenólica) e duas cultivares de alface crespa (Jullie e TPC). Foram avaliadas as características massa fresca e seca da parte aérea, número de folhas por planta e comprimento do caule. Ocorreram diferenças significativas entre cultivares para todos os caracteres avaliados. Diferença estatística significativa entre sistemas de cultivos foi observada somente para o comprimento de caule. A interação cultivar x sistemas de cultivos não foi significativa para nenhum dos caracteres avaliados. No número de folhas por planta a cultivar TPC foi superior a “Jullie” independente do sistema de cultivo. Já para o comprimento de caule, constatou-se que as duas cultivares apresentaram valores superiores no sistema floating em relação à espuma fenólica e que a cultivar Jullie apresentou comprimento de caule maior que a “TPC” na espuma fenólica. Esses valores mais altos são indesejáveis, uma vez que são responsáveis pelo pendoamento precoce na alface. Para a massa seca da parte aérea verificou-se que a cultivar Jullie foi superior a “TPC” na espuma fenólica, porém não ocorreu diferença entre elas no sistema floating. Conclui-se que nas condições em que foi conduzido o experimento que a cultivar Jullie apresentou maior massa fresca da parte aérea do que a cultivar TPC e que no número de folhas a “TPC” se destacou em relação à “Jullie” e que os sistemas de cultivos não influenciaram no rendimento das cultivares

Design of a GMP-ready single-pass tangential flow filtration (SPTFF) and inline diafiltration (LILDF) system for continuous manufacturing operations

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Perceptions of Change in the Natural Environment produced by the First Wave of the COVID-19 Pandemic across Three European countries. Results from the GreenCOVID study

Although different studies have evaluated the positive impacts of the COVID-19 pandemic and lockdown mea- sures on reducing noise pollution and traffic levels and improving air quality, how populations have perceived such changes in the natural environment has not been adequately evaluated. The present study provides a more in-depth exploration of human population perception of enhanced natural exposure (to animal life and nature sounds) and reduced harmful exposure (by improved air quality and reduced traffic volume) as a result of the COVID-19 pandemic lockdown. The data is drawn from 3,109 unselected adults who participated in the Green COVID survey from April to July 2020 in England, Ireland, and Spain. The findings suggest that the positive impacts to the natural environment as a result of the lockdown have been better received by the population in Spain and Ireland, in comparison to England. Participants who resided in urban areas had better perceived improvements in nature sounds, air quality, and traffic volume compared to those in rural areas. Older pop- ulations and those with lower smoking and alcohol consumption were found to perceive this improvement the most. Furthermore, the greater perception of improvements in environmental elements was also associated with better self-perceived health and improved wellbeing. In the binary logistic regression, living in Ireland or Spain, urban areas, female gender, older age, and good overall wellbeing were associated with a greater perception of improvements in the natural environment, while the factors most associated with a greater perception of reduced harmful exposure were living in Spain, had a good self-perceived health status and older age

A randomized controlled phase III study of VB-111 combined with bevacizumab vs bevacizumab monotherapy in patients with recurrent glioblastoma (GLOBE).

BackgroundOfranergene obadenovec (VB-111) is an anticancer viral therapy that demonstrated in a phase II study a survival benefit for patients with recurrent glioblastoma (rGBM) who were primed with VB-111 monotherapy that was continued after progression with concomitant bevacizumab.MethodsThis pivotal phase III randomized, controlled trial compared the efficacy and safety of upfront combination of VB-111 and bevacizumab versus bevacizumab monotherapy. Patients were randomized 1:1 to receive VB-111 1013 viral particles every 8 weeks in combination with bevacizumab 10 mg/kg every 2 weeks (combination arm) or bevacizumab monotherapy (control arm). The primary endpoint was overall survival (OS), and secondary endpoints were objective response rate (ORR) by Response Assessment in Neuro-Oncology (RANO) criteria and progression-free survival (PFS).ResultsEnrolled were 256 patients at 57 sites. Median exposure to VB-111 was 4 months. The study did not meet its primary or secondary goals. Median OS was 6.8 versus 7.9 months in the combination versus control arm (hazard ratio, 1.20; 95% CI: 0.91-1.59; P = 0.19) and ORR was 27.3% versus 21.9% (P = 0.26). A higher rate of grades 3-5 adverse events was reported in the combination arm (67% vs 40%), mainly attributed to a higher rate of CNS and flu-like/fever events. Trends for improved survival with combination treatment were seen in the subgroup of patients with smaller tumors and in patients who had a posttreatment febrile reaction.ConclusionsIn this study, upfront concomitant administration of VB-111 and bevacizumab failed to improve outcomes in rGBM. Change of treatment regimen, with the lack of VB-111 monotherapy priming, may explain the differences from the favorable phase II results.Clinical trials registrationNCT02511405

Protocol of the baseline assessment for the Environments for Healthy Living (EHL) Wales cohort study

Background Health is a result of influences operating at multiple levels. For example, inadequate housing, poor educational attainment, and reduced access to health care are clustered together, and are all associated with reduced health. Policies which try to change individual people's behaviour have limited effect when people have little control over their environment. However, structural environmental change and an understanding of the way that influences interact with each other, has the potential to facilitate healthy choices irrespective of personal resources. The aim of Environments for Healthy Living (EHL) is to investigate the impact of gestational and postnatal environments on health, and to examine where structural change can be brought about to optimise health outcomes. The baseline assessment will focus on birth outcomes and maternal and infant health. Methods/Design EHL is a longitudinal birth cohort study. We aim to recruit 1000 pregnant women in the period April 2010 to March 2013. We will examine the impact of the gestational environment (maternal health) and the postnatal environment (housing and neighbourhood conditions) on subsequent health outcomes for the infants born to these women. Data collection will commence during the participants' pregnancy, from approximately 20 weeks gestation. Participants will complete a questionnaire, undergo anthropometric measurements, wear an accelerometer, compile a food diary, and have environmental measures taken within their home. They will also be asked to consent to having a sample of umbilical cord blood taken following delivery of their baby. These data will be complemented by routinely collected electronic data such as health records from GP surgeries, hospital admissions, and child health and development records. Thereafter, participants will be visited annually for follow-up of subsequent exposures and child health outcomes. Discussion The baseline assessment of EHL will provide information concerning the impact of gestational and postnatal environments on birth outcomes and maternal and infant health. The findings can be used to inform the development of complex interventions targeted at structural, environmental factors, intended to reduce ill-health. Long-term follow-up of the cohort will focus on relationships between environmental exposures and the later development of adverse health outcomes, including obesity and diabetes

Altimetry for the future: Building on 25 years of progress

In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the ‘‘Green” Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instruments’ development and satellite missions’ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion