Public policy (not the coronavirus) should shape what endemic means

Endemicity is not only a biological and health event but has several inter-dependencies cross-cutting with the management of the economy, including governance and policies. Within the context of the discourse on inequity, what does endemicity mean for poor and low-income families, where policies on social inclusion and social welfare need to be re-calibrated

Pediatric melanoma: Analysis of an international registry

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/101810/1/cncr28289.pd

The effects of quercetin on SW480 human colon carcinoma cells: a proteomic study

BACKGROUND: High fruit and vegetable intake is known to reduce the risk of colon cancer. To improve understanding of this phenomenon the action of different phytochemicals on colon cells has been examined. One such compound is quercetin that belongs to the group known as flavonoids. The purpose of this study was to determine the influence of quercetin on the proteome of the SW480 human colon adenocarcinoma cell line, specifically to identify proteins that could be the molecular targets of quercetin in its amelioration of the progression of colon cancer. To this end, two-dimensional gel electrophoresis and mass spectrometry were used to identify proteins that underwent a change in expression following treatment of the cells with 20 μM quercetin. This could elucidate how quercetin may reduce the progression of colon cancer. RESULTS: Quercetin treatment of the SW480 human colon cancer cells was found to result in the decreased expression of three proteins and the increased expression of one protein. The identified proteins with decreased expression were type II cytoskeletal 8 keratin and NADH dehydrogenase Fe-S protein 3. The other protein with decreased expression was not identified. The protein with increased expression belonged to the annexin family. CONCLUSION: Several proteins were determined to have altered expression following treatment with quercetin. Such changes in the levels of these particular proteins could underlie the chemo-protective action of quercetin towards colon cancer

Preliminary Results from a Coordinated Hisaki/Chandra/XMM-Newton Study of the Jovian Aurora and Io Plasma Torus

We present preliminary results from a coordinated Hisaki/Chandra/XMM-Newton observational campaign of the Jovian aurora and Io plasma torus. The data were taken over a three week period in April, 2014. Jupiter was observed continuously with Hisaki, six times with the Chandra/HRC instrument for roughly 12 hours per observation, and twice by XMM-Newton. The goal of this observational campaign was to understand how energy and matter are exchanged between the Jovian aurora, the IPT, and the Solar wind. X-ray observations provide key diagnostics on highly stripped ions and keV electrons in the Jovian magnetosphere. We use the temporal, spatial, and spectral capabilities of the three instruments to search for correlated variability between the Solar wind, the EUV-emitting plasma of the IPT and UV aurora, and the ions responsible for the X-ray aurora. Preliminary analysis suggests a strong 45 min periodicity in the EUV emission from the electron aurora. There is some evidence for complex variability of the X-ray auroras on scales of tens of minutes. There is also clear morphological changes in the X-ray aurora that do not appear to be correlated with either variations in the IPT or Solar wind

Genome-wide association study identifies the first germline genetic variant associated with Erdheim Chester disease

[Objective] Erdheim-Chester disease (ECD) is rare histiocytosis with a wide range of clinical manifestations. Somatic mutations are key to the pathogenesis of the disease; however, the relationship between germline genetic variants and ECD has not been examined so far. The present study aims to explore the inherited genetic component of ECD by performing the first genome-wide association study.[Methods] After quality controls, a cohort of 255 ECD patients and 7,471 healthy donors was included in this study. Afterwards, a logistic regression followed by in silico functional annotation was performed.[Results] A signal at the 18q12.3 genomic region was identified as a new susceptibility locus for ECD (p-value=2.75x10-11; OR=2.09). This association was annotated to the SETBP1 gene, which is involved in clonal haematopoiesis. Functional annotation of this region and of the identified suggestive signals revealed additional genes that could be potentially involved in the pathogenesis of the disease.[Conclusion] Overall, this work demonstrates that germline genetic variants can impact on the development of ECD and suggests new pathways with a potential pathogenic role.This work was supported by the project “Genome-wide and epigenome-wide association study in patients with Erdheim-Chester Disease”, funded by by Histio UK, and supported in part by the Intramural Research Program of the National Human Genome Research Institute and Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) (RD21/0002/0039). M.A.H. is a recipient of a Miguel Servet fellows hip (CP21/00132) from Instituto de Salud Carlos III. L.O.F. was supported by a Juan de la Cierva Incorporación fellowship (IJC2019-040746-I) funded by MCIN/AEI/10.13039/501100011033.Peer reviewe