Meeting report : Neuropathology and Neuropharmacology of Monoaminergic systems

The third EU COST Action CM1103 “Structure-based drug design for diagnosis and treatment of neurological diseases: dissecting and modulating complex function in the monoaminergic systems of the brain” Annual Conference entitled “Neuropathology and Neuropharmacology of Monoaminergic Systems” was hosted by the University of Bordeaux, France on 8-10 October 2014. The conference, organized by Prof. De Deurwaerdère, was supported by COST (European Cooperation in Science and Technology) and LABEX (LABEX Brain, University of Bordeaux). The program took the form of a three-day meeting, comprising a series of French and international invited talks and breakout sessions designed to identify key gaps in current knowledge and potential future research questions. The aims of this Conference were two-fold: 1. To identify the current state-of-the-art in the understanding of the pathological mechanisms that contribute to different neuropsychiatric disorders, and to what extent, monoamines a multi-target drugs and/or other interventions might prevent these changes. 2. To identify specific areas of research where information is sparse but which are likely to yield data that will impact on future strategies to treat neurodegenerative disorders.peer-reviewe

Shared genetic contribution of type 2 diabetes and cardiovascular disease: Implications for prognosis and treatment

Purpose of Review: The increased cardiovascular disease (CVD) risk in subjects with type 2 diabetes (T2D) is well established. This review collates the available evidence and assesses the shared genetic background between T2D and CVD: the causal contribution of common risk factors to T2D and CVD and how genetics can be used to improve drug development and clinical outcomes. Recent Findings: Large-scale genome-wide association studies (GWAS) of T2D and CVD support a shared genetic background but minimal individual locus overlap. Summary: Mendelian randomisation (MR) analyses show that T2D is causal for CVD, but GWAS of CVD, T2D and their common risk factors provided limited evidence for individual locus overlap. Distinct but functionally related pathways were enriched for CVD and T2D genetic associations reflecting the lack of locus overlap and providing some explanation for the variable associations of common risk factors with CVD and T2D from MR analyses

Diagnostic Performance-Based Assessmentl: A Tool for the Kindergarten and Primary Grade Teacher

Most elementary educators agree that assessment is a necessary preparation for instructional planning. Teachers can use one of several standardized instruments or an informal reading inventory to assess the abilities of their reading students. A problem occurs for the teacher of non-readers or the teacher of beginning readers. These students cannot be assessed with instruments requiring reading ability. They need to be evaluated with instruments that sample their ability to perform with psycho-motor, auditory, oral, and visual skill areas. These areas are the foundation of beginning reading instruction and should be measured and evaluated prior to instructional planning for each kindergarten and primary school child

Tingkat Kenyamanan Taman Honda Tebet Sebagai Ruang Interaksi Sosial

Taman kota kini makin dilirik warga kota sebagai sebagai salah satu ruang public untuk untuk berkumpul dan melakukan interaksi-interaksi social. Salah satu taman kota yang ramai dikunjungi oleh warga kota Jakarta dari segala usia adalah Taman Honda Tebet. Di taman ini terdapat berbagai kegiatan public seperti senam, tae kwon do, jogging, kegiatan promosi, temu komunitas, dan lain-lain. Oleh karena itu penelitian ini ingin menguji bagamanakah Kenyamanan Taman Honda Tebet sebagai ruang interaksi masyarakat perkotaan. Metode yang digunakan adalah kuantitatif deskriptif dan metode pengumpulan datanya menggunakan observasi dan kuosioner. Tujuan penelitian ini adalah untuk mengetahui seberapa nyaman Taman Honda Tebet sebagai ruang interaksi social masyarakat perkotaan

Evaluasi Desain Ruang Publik Ramah Anak di Rptra Akasia

Belakangan ini di kota Jakarta sedang digalakkan RPTRA (Ruang Publik Terbuka Ramah Anak) yang sesuai namanya, diklaim sebagai ruang publik yang ramah anak. Namun pada Kenyataannya tidak semua RPTRA ramah anak. Hal ini membuat peneliti ingin mencaritahu apakah benar yang ada sudah benar-benar layak anak?. Dan studi kasus yang diangkat adalah RPTRA Akasia yang berada di daerah Tebet. RPTRA ini didirikan oleh Tanoto Foundation dan merupakan salah satu RPTRA yang dikelola dengan baik, dan cukup lengkap fasilitasnya. Penelitian ini menggunakan pendekatan metode penelitian kuantitatif, dan metode pengumpulan datanya menggunakan observasi dan kuosioner. Kriteria yang digunakan untuk mengukur kelayak-anakan RPTRA adalah kriteria pengendalian perancangan taman bermain anak-anak ini terdiri dari 6 kriteria yaitu : Keselamatan, Kesehatan, Kenyamanan, Kemudahan, Keamanan, Keindahan. Dan berdasarkan kriteria tersebut RPTRA Akasia yang didirikan oleh lembaga CSR Tanoto Foundation adalah layak anak baik menurut observasi maupun persepsi orang tua anak

Preferensi Masyarakat terhadap Taman Sudirman Semarang sebagai Playground

Taman adalah bagian dari ruang terbuka yang tidak bisa dilepaskan dari wajah kota. Taman aktif merupakan kebutuhan vital bagi masyarakat kota, namun pada Kenyataannya tidak semua taman aktif di kota Semarang ini ramai dikunjungi oleh masyarakat. Untuk itu penelitian ini ingin mengetahui kesukaan masyarakat terhadap taman aktif, dengan mengambil contoh kasus taman Sudirman yang cukup ramai dikunjungi masyarakat setiap harinya baik pagi, siang, sore maupun malam.Penelitian ini akan diteliti dengan menggunakan paradigma kuantitatif dan metodologi post positivistik rasionalistik dimana kasus ini diteliti dengan menggunakan teori yang sudah ada, dan hasil dari penelitian ini diharapkan akan dapat memperkaya teori yang sudah ada. Dalam penelitian ini, kondisi fisik taman Sudirman yang akan menjadi variabel bebas, yaitu kondisi fisik taman Sudirman sebagai playground.Grand theory yang dipakai untuk penelitian ini adalah teori tentang kesukaan atau kecenderungan manusia yaitu teori preferensi, dimana pada teori ini yang mempunyai aspek kerangka koherensi, kompleksitas, misteri dan keterbacaan.Tujuan dari penelitian ini adalah untuk menguji teori preferensi dalam kasus taman Sudirman dan hasil dari penelitian ini diharapkan kita dapat mengidentifikasi taman sebagai playground yang bagaimana yang disukai oleh masyarakat Semarang

The Effectiveness of Using Cooperative Script Method to Teach Students' Speaking Ability at the Eighth Grade Student's of SMP Negeri 1 Buay Bahuga

The title of this study was the effectiveness of using cooperative script method to teach students speaking ability at the eighth grade students' of SMP Negeri 1 Buay Bahuga. The formulation problem of this study was “Is there any significant difference between the students who are taught by using Cooperative Script method and the students who are taught by using conventional method to teach speaking ability”. And the objective of the study was to find out whether or not significance between the students who are taught by using Cooperative Script method and the students who are taught by using conventional method to teach speaking ability at the eighth grade students of SMP Negeri 1 Buay Bahuga in academic year 2015/2016. In this study was quantitative reseacrh, the writer used true experimental method and experimental design. Therefore, there were two groups those were control group who are taught using conventional method and experimental group who are taught using cooperative script, that was chosen by using cluster random sampling in collecting the data, the population of this study were 153 students and samples were 50 students. The data obtained from Independent ttest analysis by using SPSS 20, between the result of posttest in experimental group and control group. Based on the calculation by using Independent ttest in SPSS 20, the writer found that tobtained was higher than ttable (5.005 > 2.021) at the significant level α=0.05 in two tailed testing. It meant that there were any significant differences between experimental group and control group. So, the null hypotheses (Ho) was rejected and alternative hypotheses (Ha) was accepted. It can be concluded that cooperative script method was significantly effective in teaching speaking ability at the eighth grade students of SMP Negeri 1 Buay Bahuga

MAO and aggression

PreprintNon peer reviewe