Resampling Logistic Regression Untuk Penanganan Ketidakseimbangan Class Pada Prediksi Cacat Software

Software yang berkualitas tinggi adalah software yang dapat membantu proses bisnis Perusahaan dengan efektif, efesien dan tidak ditemukan cacat selama proses pengujian, pemeriksaan, dan implementasi. Perbaikan software setelah pengirimana dan implementasi, membutuhkan biaya jauh lebih mahal dari pada saat pengembangan. Biaya yang dibutuhkan untuk pengujian software menghabisakan lebih dari 50% dari biaya pengembangan. Dibutuhkan model pengujian cacat software untuk mengurangi biaya yang dikeluarkan. Saat ini belum ada model prediksi cacat software yang berlaku umum pada saat digunakan digunakan. Model Logistic Regression merupakan model paling efektif dan efesien dalam prediksi cacat software. Kelemahan dari Logistic Regression adalah rentan terhadap underfitting pada dataset yang kelasnya tidak seimbang, sehingga akan menghasilkan akurasi yang rendah. Dataset NASA MDP adalah dataset umum yang digunakan dalam prediksi cacat software. Salah satu karakter dari dataset prediksi cacat software, termasuk didalamnya dataset NASA MDP adalah memiliki ketidakseimbangan pada kelas. Untuk menangani masalah ketidakseimbangan kelas pada dataset cacat software pada penelitian ini diusulkan metode resampling. Eksperimen dilakukan untuk membandingkan hasil kinerja Logistic Regression sebelum dan setelah diterapkan metode resampling. Demikian juga dilakukan eksperimen untuk membandingkan metode yang diusulkan hasil pengklasifikasi lain seperti Naïve Bayes, Linear Descriminant Analysis, C4.5, Random Forest, Neural Network, k-Nearest Network. Hasil eksperimen menunjukkan bahwa tingkat akurasi Logistic Regression dengan resampling lebih tinggi dibandingkan dengan metode Logistric Regression yang tidak menggunakan resampling, demikian juga bila dibandingkan dengan pengkalisifkasi yang lain. Dari hasil eksperimen di atas dapat disimpulkan bahwa metode resampling terbukti efektif dalam menyelesaikan ketidakseimbangan kelas pada prediksi cacat software dengan algoritma Logistic Regression

Hubungan Antara Perkembangan Sektor Keuangan dengan Volatilitas Ekonomi di Indonesia

The study is conducted to analyze the causal relationship between financial sector development and economic volatility in Indonesia during the period of 1983.2-2000.4. The study uses three kinds of variables as proxies to the financial sector development. Whereas in order to measure economic volatility, the study uses standard deviation of GDP growth derived from Generalized Autoregressive Conditional Heteroscedasticity model (GARCH). The causality test is done using Granger-causality test. If the estimated variables are not stationary, yet cointegrated, thus the causality test will be in Error Correction Model (ECM). If the estimated variables are neither stationary nor cointegrated, thus the causality test will use all variables in the ffirst difference. The result shows that there is a Granger-causality in the short run from financial development to the economic volatility when the ratio of broad money and the ratio of banking credit to GDP are used. Meanwhile, when the ratio of demand deposit to narrow money is used, there is no granger-causality relationship between financial sector development and economic volatility. Keywords: GARCH, financial sector development, economic volatility, granger causality

Información molecular obtenida a partir de pieles de la colección del Museo Regional Fagnano, Río Grande, Tierra del Fuego

En el presente trabajo se aplicaron técnicas moleculares sobre muestras poco conservadas de pieles depositadas en la colección del Museo Regional Monseñor Fagnano, Tierra del Fuego, Argentina, con el objetivo de identificar la especie con la que fueron confeccionadas. Se extrajeron pelos de mantas realizadas con pieles de guanaco (Lama guanicoe) por Selk’nam y de una piel de puma (Puma concolor) procedente de la provincia de Santa Cruz. Ambas muestras se encontraban almacenadas en el Museo Regional Monseñor Fagnano y en la Misión Salesiana Candelaria en Rio Grande, Tierra del Fuego, Argentina. La extracción de ADN de los fragmentos de pelos de 5mm de longitud se realizó en un buffer de lisis PCR-compatible. Se amplificaron por PCR fragmentos específicos de ADN mitocondrial y se secuenciaron. Las secuencias fueron comparadas con las depositadas en la base de secuencias de nucleótidos del National Center for Biotechnology Information (NCBI) de Estados Unidos. La aplicación de técnicas moleculares permitió recuperar secuencias de ADN de muestras de pieles con un estado de conservación poco óptimo para análisis genéticos, pudiendo extenderse a otras fuentes de pelos como las fibras textiles de origen arqueológico de la región.Molecular techniques were applied to samples from poorly preserved furs deposited in the collection of Monseñor Fagnano Regional Museum in Tierra del Fuego, Argentina, in order to identify the species from which they were made. Hairs were obtained from guanaco leather blankets (Lama guanicoe) and a puma fur (Puma concolor) made by Selk’nam from Santa Cruz province. Both samples have been kept in the warehouse of Monseñor Fagnano Regional Museum at the Candelaria Salesian Mission in Río Grande, Tierra del Fuego, Argentina. For DNA extraction, 5mm hair strands were digested in a PCR-compatible lysis buffer. Specific mitochondrial DNA fragments were amplified by PCR and sequenced. Nucleotide sequences were compared with those deposited in the National Center for Biotechnology Information (NCBI), USA: GenBank. The use of molecular techniques allowed us to recover sequences from poorly preserved fur samples. This can be extended to other sources of hairs and fibers of archaeological origin in the area.Asociación de Antropología Biológica de la República Argentina (AABRA

Información molecular obtenida a partir de pieles de la colección del Museo Regional Fagnano, Río Grande, Tierra del Fuego

En el presente trabajo se aplicaron técnicas moleculares sobre muestras poco conservadas de pieles depositadas en la colección del Museo Regional Monseñor Fagnano, Tierra del Fuego, Argentina, con el objetivo de identificar la especie con la que fueron confeccionadas. Se extrajeron pelos de mantas realizadas con pieles de guanaco (Lama guanicoe) por Selk’nam y de una piel de puma (Puma concolor) procedente de la provincia de Santa Cruz. Ambas muestras se encontraban almacenadas en el Museo Regional Monseñor Fagnano y en la Misión Salesiana Candelaria en Rio Grande, Tierra del Fuego, Argentina. La extracción de ADN de los fragmentos de pelos de 5mm de longitud se realizó en un buffer de lisis PCR-compatible. Se amplificaron por PCR fragmentos específicos de ADN mitocondrial y se secuenciaron. Las secuencias fueron comparadas con las depositadas en la base de secuencias de nucleótidos del National Center for Biotechnology Information (NCBI) de Estados Unidos. La aplicación de técnicas moleculares permitió recuperar secuencias de ADN de muestras de pieles con un estado de conservación poco óptimo para análisis genéticos, pudiendo extenderse a otras fuentes de pelos como las fibras textiles de origen arqueológico de la región.Molecular techniques were applied to samples from poorly preserved furs deposited in the collection of Monseñor Fagnano Regional Museum in Tierra del Fuego, Argentina, in order to identify the species from which they were made. Hairs were obtained from guanaco leather blankets (Lama guanicoe) and a puma fur (Puma concolor) made by Selk’nam from Santa Cruz province. Both samples have been kept in the warehouse of Monseñor Fagnano Regional Museum at the Candelaria Salesian Mission in Río Grande, Tierra del Fuego, Argentina. For DNA extraction, 5mm hair strands were digested in a PCR-compatible lysis buffer. Specific mitochondrial DNA fragments were amplified by PCR and sequenced. Nucleotide sequences were compared with those deposited in the National Center for Biotechnology Information (NCBI), USA: GenBank. The use of molecular techniques allowed us to recover sequences from poorly preserved fur samples. This can be extended to other sources of hairs and fibers of archaeological origin in the area.Asociación de Antropología Biológica de la República Argentina (AABRA

ANALISIS YURIDIS TINDAK PIDANA KECELAKAAN LALU LINTAS BERAKIBAT KEMATIAN (STUDI PENELITIAN DIWILAYAH HUKUM POLRES KOTA LHOKSEUMAWE)

The Law Number 22 of 2009 on Traffic and Transportation has given juridical regulation to traffic order. Numerous traffic accidents in the area of police station of Lhokseumawe city from 2016 to 2018 occurred due to the negligence of driver that cause casualties even death. The study aimed to describe the criminal act of traffic accident fatality and the causes in the area of Police Station of Lhokseumawe. The study also attempted to examine the efforts of the traffic police of police station in Lhokseumawe to manage the criminal act of traffic accident fatality and the obstacles. This study used qualitative methods with sociological juridical approach. Data obtained through library research and field research. Data analysis was conducted by using descriptive analysis. Based on the results, it can be concluded that the criminal act of traffic accident fatality in the area of police station in Lhokseumawe is caused by negligence (culpa) of driver and noncompliance with the traffic laws. Majority of the accident is caused by one vehicle overtaking another vehicle. While the efforts to manage violations of traffic law was carried out preventively and repressively by the police station of Lhokseumawe. However, it might not be able to eliminate the violation directly but it can give a warning to the traffic violator. To present an intact image of law to the public, it is suggested that the traffic police of Lhokseumawe city to handle traffic accidents using the strategy of single site (fixing sharp bend), mass action plans (coating the road surface), route action plans (improving traffic signs facilities), and area wide schemes (reducing vehicle speed on specific location), as well as improvements in the internal of police station in Lhokseumawe city. Keywords: Juridical Analysis, Criminal Act, Accident, Traffi

Insights into GABA receptor signalling in TM3 Leydig cells

gamma-Aminobutyric acid (GABA) is an emerging signalling molecule in endocrine organs, since it is produced by endocrine cells and acts via GABA(A) receptors in a paracrine/autocrine fashion. Testicular Leydig cells are producers and targets for GABA. These cells express GABA(A) receptor subunits and in the murine Leydig cell line TM3 pharmacological activation leads to increased proliferation. The signalling pathway of GABA in these cells is not known in this study. We therefore attempted to elucidate details of GABA(A) signalling in TM3 and adult mouse Leydig cells using several experimental approaches. TM3 cells not only express GABA(A) receptor subunits, but also bind the GABA agonist {[}H-3] muscimol with a binding affinity in the range reported for other endocrine cells (K-d = 2.740 +/- 0.721 nM). However, they exhibit a low B-max value of 28.08 fmol/mg protein. Typical GABA(A) receptor-associated events, including Cl- currents, changes in resting membrane potential, intracellular Ca2+ or cAMP, were not measurable with the methods employed in TM3 cells, or, as studied in part, in primary mouse Leydig cells. GABA or GABA(A) agonist isoguvacine treatment resulted in increased or decreased levels of several mRNAs, including transcription factors (c-fos, hsf-1, egr-1) and cell cycle-associated genes (Cdk2, cyclin D1). In an attempt to verify the cDNA array results and because egr-1 was recently implied in Leydig cell development, we further studied this factor. RT-PCR and Western blotting confirmed a time-dependent regulation of egr-1 in TM3. In the postnatal testis egr-1 was seen in cytoplasmic and nuclear locations of developing Leydig cells, which bear GABA(A) receptors and correspond well to TM3 cells. Thus, GABA acts via an untypical novel signalling pathway in TM3 cells. Further details of this pathway remain to be elucidated. Copyright (c) 2005 S. Karger AG, Base