2,757 research outputs found
Influence of Controlled Breathing on Cerebrovascular Control During Upright Tilt
Arterial pressures oscillate with the frequency of respiration, and these oscillations are translated directly to the cerebrovasculature. For this reason, intrinsic cerebrovascular control is assessed at the low frequency (LF; .07-.2 Hz). When humans breathe spontaneously, it is possible that breathing frequency encroaches on these non-respiratory rhythms, thereby confounding the interpretation of intrinsic cerebrovascular control. PURPOSE: To test the hypothesis that controlled breathing (CB) decreases, and spontaneous breathing (SB) increases the reliance of cerebral blood velocity on arterial pressure within the LF range in both the supine and upright postures. METHODS: We recorded ECG, finger arterial pressure (Finometer), transcranial Doppler ultrasound of the middle cerebral artery, and end-tidal CO₂ in 20 healthy male volunteers (24±2 yrs). Ten subjects breathed in time to a metronome set at a pace of 15 breaths/min (CB), and ten subjects breathed spontaneously (SB). Both groups were studied in the supine and head-up tilt (HUT) positions for 5-min. Reliance of mean cerebral blood velocity (CBVmean) on mean arterial pressure (MAP) was assessed over the LF with cross-spectral coherence analysis (COH). RESULTS: Respiratory rates were not different between CB and SB during supine (p=.86), but were lower for SB compared with CB during HUT (11.7±.7 vs. 14.8±.1; p\u3c.001). End-tidal CO₂ was decreased by CB during both supine and HUT (p\u3c.05). CBVmean was decreased with CB during supine (p=.04), but was similar between CB and SB during HUT (p=.14). Neither LFMAP nor LFCBVmean oscillations were different in the supine position (p\u3e.6), but were increased (with a trend for LFMAP) with SB during HUT (p=.003 for LF CBVmean and p=.09 for LFMAP). COH was not different in the supine position between CB and SB (.42±.05 for CB and .61±.06 SB; p=.13), but was lower for CB in the HUT position (.55±.05 for CB and .78±.08 for SB; p=.02). CONCLUSION: Reliance of CBVmean on MAP is increased in the LF range when subjects breathe spontaneously during HUT. We attribute changes in COH during HUT to entrainment of respiratory-mediated arterial pressure fluctuations on the cerebrovasculature. However, the potential confounding influence of hypocapnia warrants further investigation
Effects of Hypovolemia on Cerebral Blood Velocity and Autoregulation During Upright Tilt: Implications for Post-Spaceflight Orthostasis
Orthostatic stability depends on maintenance of adequate cerebral blood flow. Orthostatic instability experienced by returning astronauts is associated with microgravity-induced hypovolemia, suggesting that hypovolemia may disrupt the ability of the cerebral vasculature to regulate blood flow. PURPOSE: To test the hypothesis that hypovolemia reduces cerebral blood velocity and impairs cerebral autoregulation (CA) during upright tilt. METHODS: Nine males (age 23 ± .5 yrs; height 172 ± 2 cm; weight 87 ± 3 kg; mean ± SE) were tilted head-up to 70° on two occasions separated by at least 5 days under euhydration (EUH) and dehydration (DEH) conditions. Dehydration was induced with 40 mg Furosemide and 8 h water restriction. Plasma volumes (PV) and blood volumes (BV) were estimated from venous hemoglobin and hematocrit. ECG, beat-by-beat finger arterial pressures, and cerebral blood velocity (CBV) were measured during a five min supine baseline, and during the first (T1) and last (T2) five min of upright tilt. Dynamic CA was assessed in the frequency domain with cross-spectral analysis of mean arterial pressure (MAP) and mean CBV within the frequency range of 0.07-0.2 Hz. RESULTS: Furosemide reduced PV by 10 ± 2 % and BV by 6 ± 2 % (P = .005 and P = .07). MAP decreased during tilt (P \u3c .007), but the reduction was similar between hydration conditions. CBV during DEH was lower during the entire 10-min tilt by about 7 cm/s (P \u3c .004) compared with EUH. Low frequency coherence was higher during DEH T1 compared with EUH T1 (.67 ± .04 vs .51 ± .04; P = .02), but coherence decreased as tilt continued, and was similar to EUH during T2 (P = 0.7). CONCLUSIONS: Increased coherence during the first 5 min of tilt suggests that reductions of CBV with hypovolemia might be explained by a reduced autoregulatory capacity. However, maintenance of lower CBV despite reduced coherence during the second 5 min of tilt suggests that disruptions of autoregulatory capacity with hypovolemia are transient. Our results provide evidence that hypovolemic astronauts may be at greatest risk for orthostatic intolerance immediately upon assumption of upright posture
Sites other than nucleotide 234 determine cardiovirulence in natural isolates of coxsackievirus B3
Cerebrovascular Hemodynamics during Concentric and Eccentric Phases of Heavy Resistance Exercise
Rapid and drastic fluctuations in arterial blood pressures, such as those occurring during heavy resistance exercise pose a unique challenge to the maintenance of cerebral perfusion. During high-intensity leg cycling, regulation of cerebral perfusion is reduced by rapid decreases in beat-to-beat fluctuations in blood pressure (diastolic phase) rather than rapid increases (systolic phase). The purpose of this study was to test the hypothesis that rhythmic heavy resistance exercise will similarly impair the regulation of cerebral blood flow during the diastolic phase of beat-to-beat fluctuations in pressure. We studied seven healthy male subjects. Beat-to-beat finger arterial pressures, and middle cerebral artery blood velocity (MCAv) were measured during 10 repetitions (REP) of rhythmic high intensity leg press exercise. Velocities and arterial pressures were evaluated during both the isotonic concentric and eccentric phases of each REP. The Gosling pulsatility index (PI) of MCAv of each REP was calculated as MCAv systolic-MCAv diastolic/MCAv mean. During the concentric phase, systolic arterial pressures progressively increased from REP 1 through REP 10 (P \u3c 0.001), while systolic MCAv was not different across all REPs (P \u3e0.2). Diastolic arterial pressures during the eccentric phase also increased from REP 1 through REP 10 (P = 0.03) however diastolic MCAv decreased during REPs 7-10 compared with REP 2 (P ≤ 0.02). MCAv PI also increased during REP 7-10 compared to REP 2 (P ≤ 0.02). Similar to high-intensity leg cycling, our data suggest that during rhythmic high-intensity leg press exercise, cerebral perfusion is well controlled during periods of rapid increases in blood pressure, but regulation of cerebral perfusion is impaired during the diastolic phase of beat-to-beat fluctuations in pressure
Cetaceans of Venezuela: Their distribution and conservation status.
Sighting, stranding, and capture records of whales and dolphins for Venezuela were assembled and analyzed to document the Venezuelan cetacean fauna and its distribution in the eastern Caribbean. An attempt was made to confirm species identification for each of the records, yielding 443 that encompass 21 species of cetaceans now confirmed to occur in Venezuelan marine, estuarine, and freshwater habitats. For each species, we report its global and local distribution, conservation status and threats, and the common names used, along with our proposal for a Spanish common name. Bryde’s whale (Balaenoptera edeni) is the most commonly reported mysticete. The long-beaked common dolphin (Delphinus capensis) is the most frequent of the odontocetes in marine waters. The boto or tonina (Inia geoffrensis) was found to be ubiquitous in the Orinoco watershed. The distribution of marine records is consistent with the pattern of productivity of Venezuelan marine waters, i.e., a concentration at 63°07′W through 65°26′W with records declining to the east and to the west. An examination of the records for all cetaceans in the Caribbean leads us to conclude that seven additional species may be present in Venezuelan waters. (PDF file contains 61 pages.
Evidence from K2 for rapid rotation in the descendant of an intermediate-mass star
Using patterns in the oscillation frequencies of a white dwarf observed by
K2, we have measured the fastest rotation rate, 1.13(02) hr, of any isolated
pulsating white dwarf known to date. Balmer-line fits to follow-up spectroscopy
from the SOAR telescope show that the star (SDSSJ0837+1856, EPIC 211914185) is
a 13,590(340) K, 0.87(03) solar-mass white dwarf. This is the highest mass
measured for any pulsating white dwarf with known rotation, suggesting a
possible link between high mass and fast rotation. If it is the product of
single-star evolution, its progenitor was a roughly 4.0 solar-mass
main-sequence B star; we know very little about the angular momentum evolution
of such intermediate-mass stars. We explore the possibility that this rapidly
rotating white dwarf is the byproduct of a binary merger, which we conclude is
unlikely given the pulsation periods observed.Comment: 5 pages, 4 figure, 1 table; accepted for publication in The
Astrophysical Journal Letter
Arterial Pulse Wave Velocities are Unchanged Following 12 Weeks of Circuit Weight Training
Arterial stiffness is decreased after vigorous endurance training and increased after high-intensity resistance training. The effects of a combined program of moderate endurance and resistance exercise on arterial stiffness have not been determined. PURPOSE: To determine whether12 weeks of circuit weight training will decrease both central and peripheral arterial stiffness as estimated from pulse wave velocity (PWV). METHODS: Thirteen males and eight females (age 22 ± 2, height 162 ± 8 cm, weight 78 ± 20 kg) were assigned to control (n = 10) or exercise (n = 11) groups. Aerobic capacity and muscular strength were assessed before and at the end of the 12 week period. Arterial pressures and PWV (Doppler) were recorded every four weeks. Velocities from the carotid to femoral artery and from the femoral to dorsalis pedis artery were used as estimates of central and peripheral stiffness. RESULTS: Muscular strength increased by 26% (P = .001) and VO2 max increased by 17% (P = .06) following circuit training in the exercise group, but was unchanged for controls. Circuit weight training did not affect arterial pressures, (systolic = 117 ± 3, diastolic = 74 ± 3 mmHg; pooled across groups), or central and peripheral PWV (central PWV = 6.2 ± 0.6, peripheral PWV = 9.5 ± 0.7 m ∙ s-1; pooled across groups). CONCLUSIONS: In contrast to other reports of increases in arterial stiffness following high-intensity resistance training, increases in muscular strength following moderate-intensity exercise in the current study were not associated with increased arterial stiffness. Circuit training may be an appropriate exercise prescription to increase muscular strength for patients at risk for peripheral artery disease
- …