236 research outputs found
The Current State of Performance Appraisal Research and Practice: Concerns, Directions, and Implications
On the surface, it is not readily apparent how some performance appraisal research issues inform performance appraisal practice. Because performance appraisal is an applied topic, it is useful to periodically consider the current state of performance research and its relation to performance appraisal practice. This review examines the performance appraisal literature published in both academic and practitioner outlets between 1985 and 1990, briefly discusses the current state of performance appraisal practice, highlights the juxtaposition of research and practice, and suggests directions for further research
Molecular and cellular mechanisms underlying the evolution of form and function in the amniote jaw.
The amniote jaw complex is a remarkable amalgamation of derivatives from distinct embryonic cell lineages. During development, the cells in these lineages experience concerted movements, migrations, and signaling interactions that take them from their initial origins to their final destinations and imbue their derivatives with aspects of form including their axial orientation, anatomical identity, size, and shape. Perturbations along the way can produce defects and disease, but also generate the variation necessary for jaw evolution and adaptation. We focus on molecular and cellular mechanisms that regulate form in the amniote jaw complex, and that enable structural and functional integration. Special emphasis is placed on the role of cranial neural crest mesenchyme (NCM) during the species-specific patterning of bone, cartilage, tendon, muscle, and other jaw tissues. We also address the effects of biomechanical forces during jaw development and discuss ways in which certain molecular and cellular responses add adaptive and evolutionary plasticity to jaw morphology. Overall, we highlight how variation in molecular and cellular programs can promote the phenomenal diversity and functional morphology achieved during amniote jaw evolution or lead to the range of jaw defects and disease that affect the human condition
Chemical Methods for Determination of Hydroxylated Metabolites of Polycyclic Aromatic Hydrocarbons and Polychlorinated Biphenyls in Biological Material
U ovome preglednom radu prikazani su postupci analize hidroksiliranih metabolita policikliÄkih aromatskih ugljikovodika i poliklorbifenila u ljudima i ĆŸivotinjama. Ti metaboliti sluĆŸe kao biomarkeri izloĆŸenosti ljudi i ĆŸivotinja navedenim zagaÄivalima, no neki od njih i sami posjeduju toksiÄna svojstva. Analiziraju se najÄeĆĄÄe u urinu koji je kao uzorak najdostupniji, ali se isto tako mogu analizirati i u ljudskoj, odnosno ĆŸivotinjskoj jetri, ĆŸuÄi i masnom tkivu. Analiza metabolita aromatskih zagaÄivala vaĆŸna je zbog odreÄivanja biodostupnosti aromatskih zagaÄivala, njihove potencijalne toksiÄnosti u ljudskom organizmu, ali i zbog toksiÄnosti samih metabolita. Napredak analitiÄkih metoda omoguÄio je simultanu analizu velikog broja metabolita u uzorcima. Nove tehnike
ekstrakcije i selektivnije i preciznije kvalitativne i kvantitativne analize omoguÄuju detekciju vrlo niskih koncentracija metabolita. Pri tome dodatnu prednost imaju jednostavne tehnike koje zahtijevaju manje kemikalija i vremena za analizu.This review presents methods for the analysis of hydroxylated metabolites of polycyclic aromatic hydrocarbons and polychlorinated biphenyls in humans and animals. These metabolites serve as biomarkers of human and animal exposure to the mentioned pollutants, but some metabolites also have toxic properties.
Most are analysed in urine, which is the most accessible sample, but they can also be analysed in human and animal liver, bile, and adipose tissue. Their analysis is important for assessing bioavailability of aromatic pollutants and their toxicity in human
organism, but also the toxicity of metabolites themselves. Advancements in analytical methods have made it possible to analyse multiple metabolites in a sample at the same time. New extraction techniques and more precise and selective qualitative and quantitative analyses can now detect very low metabolite oncentrations. An extra advantage is that these simple techniques require less chemicals and time
From the outside in: narratives of creative arts practitioners working in the criminal justice system
This is an accepted manuscript of an article published by Wiley-Blackwell in The Howard Journal of Crime and Justice on 31/12/2019, available online: https://doi.org/10.1111/hojo.12318
The accepted version of the publication may differ from the final published version.The penal voluntary sector is highly variegated in its roles, practices and functions, though research to date has largely excluded the experiences of front-line practitioners. We argue that engaging with the narratives of practitioners can provide fuller appreciation of the potential of the sectorâs work. Though life story and narrative have been recognised as important in offender desistance (Maruna, 2001), the narrative identities of creative arts practitioners, who are important âchange agentsâ (Albertson, 2015), are typically absent. This is despite evidence to suggest that a practitionerâs life history can be a significant and positive influence in the rehabilitation of offenders (Harris, 2017). Using narratological analysis (Bal, 2009), this study examined the narratives of 19 creative practitioners in prisons in England and Wales. Of particular interest were the formative experiences of arts practitioners in their journey to prison work. The findings suggest that arts practitioners identify with an âoutsiderâ status and may be motivated by an ethic of mutual aid. In the current climate of third sector involvement in the delivery of criminal justice interventions, such a capacity may be both a strength and weakness for arts organisations working in this field
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