Satellite observations of reconnection between emerging and pre-existing small-scale magnetic fields

We report multi-wavelength ultraviolet observations taken with the IRIS satellite, concerning the emergence phase in the upper chromosphere and transition region of an emerging flux region (EFR) embedded in the unipolar plage of active region NOAA 12529. The photospheric configuration of the EFR is analyzed in detail benefitting from measurements taken with the spectropolarimeter aboard the Hinode satellite, when the EFR was fully developed. In addition, these data are complemented by full-disk, simultaneous observations of the SDO satellite, relevant to the photosphere and the corona. In the photosphere, magnetic flux emergence signatures are recognized in the fuzzy granulation, with dark alignments between the emerging polarities, cospatial with highly inclined fields. In the upper atmospheric layers, we identify recurrent brightenings that resemble UV bursts, with counterparts in all coronal passbands. These occur at the edges of the EFR and in the region of the arch filament system (AFS) cospatial to the EFR. Jet activity is also found at chromospheric and coronal levels, near the AFS and the observed brightness enhancement sites. The analysis of the IRIS line profiles reveals the heating of dense plasma in the low solar atmosphere and the driving of bi-directional high-velocity flows with speeds up to 100 km/s at the same locations. Furthermore, we detect a correlation between the Doppler velocity and line width of the Si IV 1394 and 1402 \AA{} line profiles in the UV burst pixels and their skewness. Comparing these findings with previous observations and numerical models, we suggest evidence of several long-lasting, small-scale magnetic reconnection episodes between the emerging bipole and the ambient field. This process leads to the cancellation of a pre-existing photospheric flux concentration of the plage with the opposite polarity flux patch of the EFR. [...]Comment: 4 pages, 2 figures, to be published in "Nuovo Cimento C" as proceeding of the Third Meeting of the Italian Solar and Heliospheric Communit

Height dependence of the penumbral fine-scale structure in the inner solar atmosphere

We studied the physical parameters of the penumbra in a large and fully-developed sunspot, one of the largest over the last two solar cycles, by using full-Stokes measurements taken at the photospheric Fe I 617.3 nm and chromospheric Ca II 854.2 nm lines with the Interferometric Bidimensional Spectrometer. Inverting measurements with the NICOLE code, we obtained the three-dimensional structure of the magnetic field in the penumbra from the bottom of the photosphere up to the middle chromosphere. We analyzed the azimuthal and vertical gradient of the magnetic field strength and inclination. Our results provide new insights on the properties of the penumbral magnetic fields in the chromosphere at atmospheric heights unexplored in previous studies. We found signatures of the small-scale spine and intra-spine structure of both the magnetic field strength and inclination at all investigated atmospheric heights. In particular, we report typical peak-to-peak variations of the field strength and inclination of $\approx 300$ G and $\approx 20^{\circ}$, respectively, in the photosphere, and of $\approx 200$ G and $\approx 10^{\circ}$ in the chromosphere. Besides, we estimated the vertical gradient of the magnetic field strength in the studied penumbra: we find a value of $\approx 0.3$ G km$^{-1}$ between the photosphere and the middle chromosphere. Interestingly, the photospheric magnetic field gradient changes sign from negative in the inner to positive in the outer penumbra.Comment: 14 page, 9 figures, accepted for Ap

Review about comorbidities of behavioural disorders in children and adolescents: The focus on attention-deficit/hyperactivity disorder

Disruptive behavior disorders (DBD) present high comorbidity rate mainly for opposite-defiant disorders that are frequent among children, adolescents and adults affected by with attention deficit and hyperactivity disorder (ADHD), probably as result of common temperamental risk factors such as attention, distraction, impulsivity. ADHD tend to manifest in about 50% of individuals diagnosed as disruptive behavioral disorders

Behavioural disorders in children and adolescents: A conceptual review about the therapeutic alliance with family and school

Aim: In disruptive behavioral disorders, given the wide range of symptomatic manifestations and the complexity of the sociofamiliar contexts in which they develop, it is now proven that more visible and more stable results can be achieved over time through multimodal and multidimensional interventions. These are accomplished through the integration of psychotherapeutic interventions for the child and parents, counseling interventions for all the various practitioners who come into contact with the child in school, sports, and social settings, through the possibility of organizing multiple settings in patient can be followed by several health professionals such as child and adolescent neuropsychiatrist, neuropsychomotricist, occupation therapist, psychologist

Model-informed repurposing of medicines for SARS-CoV-2: extrapolation of antiviral activity and dose rationale for paediatric patients

Repurposing of remdesivir and other drugs with potential antiviral activity has been the basis of numerous clinical trials aimed at SARS-CoV-2 infection in adults. However, expeditiously designed trials without careful consideration of dose rationale have often resulted in treatment failure and toxicity in the target patient population, which includes not only adults but also children. Here we show how paediatric regimens can be identified using pharmacokinetic-pharmacodynamic (PKPD) principles to establish the target exposure and evaluate the implications of dose selection for early and late intervention. Using in vitro data describing the antiviral activity and published pharmacokinetic data for the agents of interest, we apply a model-based approach to assess the exposure range required for adequate viral clearance and eradication. Pharmacokinetic parameter estimates were subsequently used with clinical trial simulations to characterise the probability target attainment (PTA) associated with enhanced antiviral activity in the lungs. Our analysis shows that neither remdesivir, nor anti-malarial drugs can achieve the desirable target exposure range based on a mg/kg dosing regimen, due to a limited safety margin and high concentrations needed to ensure the required PTA. To date, there has been limited focus on suitable interventions for children affected by COVID-19. Most clinical trials have defined doses selection criteria empirically, without thorough evaluation of the PTA. The current results illustrate how model-based approaches can be used for the integration of clinical and nonclinical data, providing a robust framework for assessing the probability of pharmacological success and consequently the dose rationale for antiviral drugs for the treatment of SARS-CoV-2 infection in children

Source process of the September 12, 2007 MW 8.4 Southern Sumatra earthquake from tsunami tide gauge record inversion

We infer the slip distribution and average rupture velocity of the magnitude MW 8.4 September 12, 2007, southern Sumatra earthquake from available tide-gauge records of the ensuing tsunami. We select 9 waveforms recorded along the west coast of Sumatra and in the Indian Ocean. Slip distribution and rupture velocity are determined simultaneously by means of a non linear inversion method. We find high slip values (∼10 m) into a patch 100 km long and 50 km large, between 20 and 30 km of depth, about 100 km north-west from the epicenter. We conclude this earthquake did not rupture the whole area of the 1833 event, indicating some slip has still to occurr. Our estimate of rupture velocity is of 2.1±0.4 km/sec. The relatively large depth of the main slip patch is the likely explanation for the low damaging observed tsunami

Nonclassical Light in Interferometric Measurements

It is shown that the even and odd coherent light and other nonclassical states of light like superposition of coherent states with different phases may replace the squeezed light in interferometric gravitational wave detector to increase its sensitivity. (Contribution to the Second Workshop on Harmonic Oscillator, Cocoyoc, Mexico, March 1994)Comment: 8 pages,LATEX,preprint of Naples University, INFN-NA-IV-94/30,DSF-T-94/3

Magnetic properties of quantum Heisenberg ferromagnets with long-range interactions

Quantum Heisenberg ferromagnets with long-range interactions decayin as $1/r^p$ in one and two dimensions are investigated by means of the Green's function method. It is shown that there exists a finite-temperature phase transition in the region $d<p<2 d$ for the $d$-dimensional case and that no transitions at any finite temperature exist for $p\ge 2 d$; the critical temperature is also estimated. We study the magnetic properties of this model. We calculate the critical exponents' dependence on $p$; these exponents also satisfy a scaling relation. Some of the results were also found using the modified spin-wave theory and are in remarkable agreement with each other.Comment: 13 pages(LaTeX REVTeX), 2 figures not included (postscript files available on request), submitted to Phys.Rev.

Translational control in the stress adaptive response of cancer cells: a novel role for the heat shock protein TRAP1

TNF receptor-associated protein 1 (TRAP1), the main mitochondrial member of the heat shock protein (HSP) 90 family, is induced in most tumor types and is involved in the regulation of proteostasis in the mitochondria of tumor cells through the control of folding and stability of selective proteins, such as Cyclophilin D and Sorcin. Notably, we have recently demonstrated that TRAP1 also interacts with the regulatory protein particle TBP7 in the endoplasmic reticulum (ER), where it is involved in a further extra-mitochondrial quality control of nuclear-encoded mitochondrial proteins through the regulation of their ubiquitination/degradation. Here we show that TRAP1 is involved in the translational control of cancer cells through an attenuation of global protein synthesis, as evidenced by an inverse correlation between TRAP1 expression and ubiquitination/degradation of nascent stress-protective client proteins. This study demonstrates for the first time that TRAP1 is associated with ribosomes and with several translation factors in colon carcinoma cells and, remarkably, is found co-upregulated with some components of the translational apparatus (eIF4A, eIF4E, eEF1A and eEF1G) in human colorectal cancers, with potential new opportunities for therapeutic intervention in humans. Moreover, TRAP1 regulates the rate of protein synthesis through the eIF2α pathway either under basal conditions or under stress, favoring the activation of GCN2 and PERK kinases, with consequent phosphorylation of eIF2α and attenuation of cap-dependent translation. This enhances the synthesis of selective stress-responsive proteins, such as the transcription factor ATF4 and its downstream effectors BiP/Grp78, and the cystine antiporter system xCT, thereby providing protection against ER stress, oxidative damage and nutrient deprivation. Accordingly, TRAP1 silencing sensitizes cells to apoptosis induced by novel antitumoral drugs that inhibit cap-dependent translation, such as ribavirin or 4EGI-1, and reduces the ability of cells to migrate through the pores of transwell filters. These new findings target the TRAP1 network in the development of novel anti-cancer strategies