A symmetry-adapted numerical scheme for SDEs

We propose a geometric numerical analysis of SDEs admitting Lie symmetries which allows us to individuate a symmetry adapted coordinates system where the given SDE has notable invariant properties. An approximation scheme preserving the symmetry properties of the equation is introduced. Our algorithmic procedure is applied to the family of general linear SDEs for which two theoretical estimates of the numerical forward error are established.Comment: A numerical example adde

Transformations and Permanences of landscape and architecture: the Minerva Tower of Punta Campanella in the Sorrento-Amalfi Peninsula

[EN] The Minerva Tower is placed on the Punta Campanella promontory, which is the last offshoot of the Sorrentine Peninsula and seat of suggestive archaeological and mythological memories. The strategic position contributed, over the centuries, to the settlement of important architectures, such as the sanctuary dedicated to Athena and a Roman domus, which makes the area a complex and rich palimpsest of material stratifications. The Minerva Tower – that nowadays is the main landmark of the promontory – was built in 1334 in relation to the site of the temple of Athena but was completely transformed in 1566, as a consequence of the strengthening plan of the southern coasts which was planned by the Spanish viceroy Pedro Afán de Ribera Duke of Alcalà. The paper deepens the knowledge of the tower by analyzing the transformations during the viceroyal period and highlighting the changes and the hidden ancient traces which are preserved until today.Pollone, S.; Romano, L. (2015). Transformations and Permanences of landscape and architecture: the Minerva Tower of Punta Campanella in the Sorrento-Amalfi Peninsula. En Defensive architecture of the mediterranean: XV to XVIII centuries. Vol. II. Editorial Universitat Politècnica de València. 273-280. https://doi.org/10.4995/FORTMED2015.2015.1772OCS27328

Looking for sediment distribution and heavy metals contamination: the case study of Neretva Channel (Croatia)

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Sediment Distribution and Trace Metals Contaminations in Neretva Channel (Croazia)

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Strong Kac's chaos in the mean-field Bose-Einstein Condensation

A stochastic approach to the (generic) mean-field limit in Bose-Einstein Condensation is described and the convergence of the ground state energy as well as of its components are established. For the one-particle process on the path space a total variation convergence result is proved. A strong form of Kac's chaos on path-space for the $k$-particles probability measures are derived from the previous energy convergence by purely probabilistic techniques notably using a simple chain-rule of the relative entropy. The Fisher's information chaos of the fixed-time marginal probability density under the generic mean-field scaling limit and the related entropy chaos result are also deduced

Germination behaviour of four mediterranean Cistus L. species in relation to high temperature

Cistus is one of the most characteristic genera of the Mediterranean flora. These species, natives of lands surrounding the Mediterranean Sea, are present in scrubland and garigue on siliceous ground and often on acid soil; seven species in particular are founded in Sicily. The adaptation of the genus to Mediterranean environments is evident from ecological characteristics such as fire-dependent seed germination; the heat generated by fire is in fact a key germination input.In this view, two experiments were performed to study the effects of high temperature on germination of four Cistus species (C. creticus L., C. crispus L., C. monspeliensis L., C. salviifolius L.). In the first, in relation to untreated control, 7 different high temperature pre-treatments (from 70°C to 130°C) for different timings (from 1 to 10 minutes) were analysed in relation to two sowing strategies (soon after the seed collection and after a 6 month period at 5°C to simulate the winter season effects). The pre-treatment with high temperatures can improve the germination; the storage at 5°C to simulate the winter season effects did not modify the germination process. In any case the results showed a species-dependent response. High germination percentage was obtained for C. creticus, while a lower germination rate was achieved by C. crispus and C. monspeliensis.In the second experiment, seeds were treated for different periods (80°C for 10 min, 90°C for 5 min and 100°C for 1 min) with high temperature in dry and wet (immersion in distilled water) conditions. Also in this case the responses were strictly linked to the species. Especially C. crispus and C. monspeliensis showed high germination percentage in wet conditions. In all species the wet heat treatments determined an accelerating of process like demonstrated by lower T50 values

Non-modified RNA-Based Reprogramming of Human Dermal Fibroblasts into Induced Pluripotent Stem Cells

The generation of pluripotent stem cells from adult somatic cells by cell reprogramming has put a whole new perspective on stem cell biology and stem cell-based regenerative medicine. Cell reprogramming acts through the introduction of key genes that regulate and maintain the pluripotent cell state. In this chapter, we describe the optimized protocol for the efficient isolation of fibroblasts from a skin punch biopsy and the subsequent easy and effective generation of integration-free induced pluripotent stem cell (iPSC) colonies forcing the expression of specific factors by non-modified RNAs. © 2021, Springer Science+Business Media, LLC

Electronic witness system in IVF—patients perspective

Objective The objective of this study is to evaluate patient concerns about in vitro fertilization (IVF) errors and electronic witness systems (EWS) satisfaction. Design The design of this study is a prospective single-center cohort study. Setting The setting of this study was located in the private IVF center. Patient(s) Four hundred eight infertile patients attending an IVF cycle at a GENERA center in Italy were equipped with an EWS. Intervention(s) Although generally recognized as a very rare event in IVF, biological sample mix-up has been reported in the literature. For this reason, some IVF laboratories have introduced EWS with the aim to further reduce the risk of error during biological samples handling. Participating patients received a questionnaire developed through a Likert scale ranging from 1 to 6. Main outcomes measure(s) Patient concerns about sample mix-up without and with an EWS were assessed. Result(s) 90.4 % of patients expressed significant concerns relating to sample mix-up. The EWS reduced these concerns in 92.1 % of patients, 97.1 % of which were particularly satisfied with the electronic traceability of their gametes and embryos in the IVF laboratory. 97.1 % of patients felt highly comfortable with an IVF center equipped with an EWS. Female patients had a significantly higher appreciation of the EWS when compared to their male partners (p = 0.029). A significant mix-up event occurred in an Italian hospital during the study and patient's satisfaction increased significantly towards the use of the EWS after the event (p = 0.032). Conclusion(s) EWS, by sensibly reducing the risk for sample mix-up in IVF cycles, has been proved to be a trusted strategy from patient's perspective

Imaging and therapy of ovarian cancer: Clinical application of nanoparticles and future perspectives

Despite significant advances in cancer diagnostics and treatment, ovarian cancers (OC) continue to kill more than 150,000 women every year worldwide. Due to the relatively asymptomatic nature and the advanced stage of the disease at the time of diagnosis, OC is the most lethal gynecologic malignancy. The current treatment for advanced OC relies on the synergistic effect of combining surgical cytoreduction and chemotherapy; however, beside the fact that chemotherapy resistance is a major challenge in OC management, new imaging strategies are needed to target microscopic lesions and improve both cytoreductive surgery and patient outcomes. In this context, nanostructured probes are emerging as a new class of medical tool that can simultaneously provide imaging contrast, target tumor cells, and carry a wide range of medicines resulting in better diagnosis and therapeutic precision. Herein we summarize several exemplary efforts in nanomedicine for addressing unmet clinical needs