La production des huiles essentielles en France

National audienceThe essential oil production in France : species, economy, enhancing.L'huile essentielle ou essence végétale se définit comme étant un liquide hydrophobe des composés odoriférants volatils secrété par une plante. Ce mélange complexe de diverses molécules (alcools, terpènes, cétones, etc...) est obtenu par distillation à la vapeur d'eau ; en France, ces productions originales sont partie prenante d'une filière dont l'aval est constitué par l'industrie du parfum, de la cosmétique et de l'aromathérapie. Ce petit chapitre introductif propose une vision d'ensemble de la production française d'huiles essentielles

Looking for the vector of the latest discovered geminivirus genus, Capulavirus. [P.48]

Viral metagenomics studies based on virion-associated nucleic acid extraction, sequence-independent amplification and next generation sequencing proved to be effective for discovering three highly divergent geminiviruses in South Africa, France and Finland. Although these geminiviral sequences were isolated from different continents, hemispheres and plant families, including Euphorbia caput-medusae (Euphorbiaceae), Medicago sativa (Fabaceae) and Plantago lanceolata (Plantaginaceae), they were clustered in the same phylogenetic group and were highly divergent from all the sequences classified in the seven established geminivirus genera. Based on sequence relatedness and genome organization, these new highly divergent geminivirus species were provisionally classified in a new geminivirus genus, tentatively named "Capulavirus". To estimate the epidemiological potential of these new geminiviruses but also to confirm their classification according to the criteria defined by the International Committee on Taxonomy of Viruses, including insect vector and host range, further studies were done with two capulaviruses available in our laboratory: Euphorbia caput medusae latent virus (EcmLV) from South Africa (Bernardo et al. 2013) and a capulavirus isolated from alfalfa in France provisionally named Alfalfa leaf curl virus (ALCV) according to the symptoms observed on infected plants. ALCV may cause yield losses because the infected plants exhibited stunting and distorted growth. ALCV was detected in Camargue, Provence Alpes Côte d'Azur, Languedoc Roussillon and Midi-Pyrénées. An infectious clone of EcmLV was prepared and used to determine the host range of EcmLV and test various phloem feeding insects reared in our laboratory, for vector transmission. Potentially infectious clones are presently prepared for ALCV for similar tests. In the meantime, a naturally infected alfalfa plant was transferred to a growth chamber and used as source plant for vector transmission. Potential vectors were also collected from infected alfalfa fields for testing ALCV transmission to alfalfa seedlings prepared in insect proof conditions. (Résumé d'auteur

The EGIM, modular though generic addresses the requirements of the EMSO platforms

The EGIM (EMSO Generic Instrument Module ) is designed to consistently and continuously measure parameters of interest for most major science areas covered by EMSO. This research infrastructure provides accurate records on marine environmental changes from distributed regional nodes around Europe. The system can deliver data that can support the Global Ocean Observing System –Essential Ocean Variables concept, as well as the Marine Strategy Framework Directive towards evaluating environmentalstatus. The EGIM is flexible for adaptation according to site and disciplinespecific requirements. Inter - operability and capacity of future evolution of the system are key aspects of the modularity. The EGIM is able to operate on any EMSO node type: mooring line, sea bed station, cabled or non - cabled and surface buoy to monitor environmental parameters over a wide depth range. Operating modes, power requirements, mechanical design can adapt to the various EMSO node configurations. In addition to sensors already included in the EGIM prototype (temperature, conductivity, pressure, dissolved Oxygen, Turbidity, currents and passive acoustics) the EGIMcan host up to five additional sensors such as chl -a, pCO 2, pH, seismic and photographic/video images ornew sensors. The EGIM provides all the sensor hosting services required ,for instance power distribution, positioning , and protection against bio -fouling . Within EMSO , the EGIM aimsto have a number of ocean locations where the same set of core variables are measured homogeneously: using the same hardware, same sensor references, same qualification methods, same calibration methods, same data format and access and the same maintenance procedures. It’s compact and modular nature allows for flexible deploymentscenarios that include being able to accommodate new instruments such for Essential Ocean Variables and other needs as theirtechnology readiness levels improve.Peer ReviewedPostprint (published version

Ascites and resistance to immune checkpoint inhibition in dMMR/MSI-H metastatic colorectal and gastric cancers

Gastrointestinal neoplasms; Immunotherapy; Tumor biomarkersNeoplasias gastrointestinales; Inmunoterapia; Biomarcadores tumoralesNeoplàsies gastrointestinals; Immunoteràpia; Biomarcadors tumoralsBackground Despite unprecedented benefit from immune checkpoint inhibitors (ICIs) in patients with mismatch repair deficient (dMMR)/microsatellite instability high (MSI-H) advanced gastrointestinal cancers, a relevant proportion of patients shows primary resistance or short-term disease control. Since malignant effusions represent an immune-suppressed niche, we investigated whether peritoneal involvement with or without ascites is a poor prognostic factor in patients with dMMR/MSI-H metastatic colorectal cancer (mCRC) and gastric cancer (mGC) receiving ICIs. Methods We conducted a global multicohort study at Tertiary Cancer Centers and collected clinic-pathological data from a cohort of patients with dMMR/MSI-H mCRC treated with anti-PD-(L)1 ±anti-CTLA-4 agents at 12 institutions (developing set). A cohort of patients with dMMR/MSI-high mGC treated with anti-PD-1 agents±chemotherapy at five institutions was used as validating dataset. Results The mCRC cohort included 502 patients. After a median follow-up of 31.2 months, patients without peritoneal metastases and those with peritoneal metastases and no ascites had similar outcomes (adjusted HR (aHR) 1.15, 95% CI 0.85 to 1.56 for progression-free survival (PFS); aHR 0.96, 95% CI 0.65 to 1.42 for overall survival (OS)), whereas inferior outcomes were observed in patients with peritoneal metastases and ascites (aHR 2.90, 95% CI 1.70 to 4.94; aHR 3.33, 95% CI 1.88 to 5.91) compared with patients without peritoneal involvement. The mGC cohort included 59 patients. After a median follow-up of 17.4 months, inferior PFS and OS were reported in patients with peritoneal metastases and ascites (aHR 3.83, 95% CI 1.68 to 8.72; aHR 3.44, 95% CI 1.39 to 8.53, respectively), but not in patients with only peritoneal metastases (aHR 1.87, 95% CI 0.64 to 5.46; aHR 2.15, 95% CI 0.64 to 7.27) when compared with patients without peritoneal involvement. Conclusions Patients with dMMR/MSI-H gastrointestinal cancers with peritoneal metastases and ascites should be considered as a peculiar subgroup with highly unfavorable outcomes to current ICI-based therapies. Novel strategies to target the immune-suppressive niche in malignant effusions should be investigated, as well as next-generation ICIs or intraperitoneal approaches

Cortico-autonomic local arousals and heightened somatosensory arousability during NREMS of mice in neuropathic pain.

Frequent nightly arousals typical for sleep disorders cause daytime fatigue and present health risks. As such arousals are often short, partial, or occur locally within the brain, reliable characterization in rodent models of sleep disorders and in human patients is challenging. We found that the EEG spectral composition of non-rapid eye movement sleep (NREMS) in healthy mice shows an infraslow (~50 s) interval over which microarousals appear preferentially. NREMS could hence be vulnerable to abnormal arousals on this time scale. Chronic pain is well-known to disrupt sleep. In the spared nerve injury (SNI) mouse model of chronic neuropathic pain, we found more numerous local cortical arousals accompanied by heart rate increases in hindlimb primary somatosensory, but not in prelimbic, cortices, although sleep macroarchitecture appeared unaltered. Closed-loop mechanovibrational stimulation further revealed higher sensory arousability. Chronic pain thus preserved conventional sleep measures but resulted in elevated spontaneous and evoked arousability. We develop a novel moment-to-moment probing of NREMS vulnerability and propose that chronic pain-induced sleep complaints arise from perturbed arousability

Phase Change Material Heat Accumulator for the HEXAFLY-INT Hypersonic glider

International audienceFrom the launchers to the spacecrafts, various on-board systems have to be maintained within specified temperature limits. Phase Change Materials (PCM) offer the possibility to store thermal energy directly as latent heat of fusion. Among the advantages of a PCM device are the stability of temperature control, the absence of moving parts and a reduced mass. The HEXAFLY-INTERNATIONAL project aims to flight test an experimental vehicle above Mach 7 to verify its potential for a high aerodynamic efficiency during a free-flight. European Major Resarch Centers and Industries are collaborating on this challenge. The presented activity focus on the use of a Phase Change Material device already developed under ESA projects up to TRL 6. Two efficient heat accumulators using PCM will allow avoiding overheating of electronic units such as telemetry & telecommand receivers, transmitters and data acquisition units for the hypersonic flight. The paper presents the complete cycle of design and environmental testing for the two PCM Heat Accumulators selected for the flight. The conclusions will show the benefit of adopting a Phase Change Material Heat Accumulator

The EGIM, EMSO generic instrument module, step towards standardization

Peer ReviewedPostprint (published version

The sooner the better: clinical and neural correlates of impulsive choice in Tourette disorder.

Reward sensitivity has been suggested as one of the central pathophysiological mechanisms in Tourette disorder. However, the subjective valuation of a reward by introduction of delay has received little attention in Tourette disorder, even though it has been suggested as a trans-diagnostic feature of numerous neuropsychiatric disorders. We aimed to assess delay discounting in Tourette disorder and to identify its brain functional correlates. We evaluated delayed discounting and its brain functional correlates in a large group of 54 Tourette disorder patients and 31 healthy controls using a data-driven approach. We identified a subgroup of 29 patients with steeper reward discounting, characterised by a higher burden of impulse-control disorders and a higher level of general impulsivity compared to patients with normal behavioural performance or to controls. Reward discounting was underpinned by resting-state activity of a network comprising the orbito-frontal, cingulate, pre-supplementary motor area, temporal and insular cortices, as well as ventral striatum and hippocampus. Within this network, (i) lower connectivity of pre-supplementary motor area with ventral striatum predicted a higher impulsivity and a steeper reward discounting and (ii) a greater connectivity of pre-supplementary motor area with anterior insular cortex predicted steeper reward discounting and more severe tics. Overall, our results highlight the heterogeneity of the delayed reward processing in Tourette disorder, with steeper reward discounting being a marker of burden in impulsivity and impulse control disorders, and the pre-supplementary motor area being a hub region for the delay discounting, impulsivity and tic severity