Endobronchial myxoma: Case report

INTRODUCTION: Pulmonary myxoma is an extremely rare benign neoplasm. It is mostly parenchymal but may occasionally occur within the tracheobronchial tree. There are very few reports of endobronchial myxoma. CASE REPORT: We describe a case of endobronchial myxoma in a 40-year-old female patient with a history of asthma and repeated right-sided pneumonia. Thoracic computed tomography (CT) showed medium lobe atelectasis. Fiber optic bronchoscopy revealed a polypoid, well-circumscribed tumor, causing total obstruction of the medium lobe bronchus. Biopsy of the mass was non-diagnostic. Further study included a positron emission tomography (PET) which demonstrated low metabolic activity of the tumor and no evidence of neoplasia in other location. The patient was submitted to a medium lobectomy and microscopic examination of the tumor revealed myxoid stroma with lobulated pattern, elongated and stellate cells, compatible with myxoma. CONCLUSION: Pulmonary myxoma is extraordinary rare and endobronchial location is very few reported in medical literature

The circular economy in corporate reporting: Text mining of energy companies’ management reports

This paper explores the implementation of the circular economy in the energy sector. The research findings contribute to our understanding of the practical application of the circular economy, enabling policymakers and stakeholders to make informed decisions and develop targeted strategies. The study analyzes 88 Portuguese companies’ reports, examining the presence of circular economy strategies and initiatives. The results reveal that energy sector companies tend to prioritize reporting their greenhouse gas reduction efforts over their circular economy strategies. The findings align with previous studies in the oil and gas industry, emphasizing the significance of sustainability reporting and potential biases in reporting practices. The study also identifies a gap between circular economy terminology and its representation in reports, indicating the need for greater incorporation of circular economy-oriented initiatives in the energy sector. The research highlights the role of technology in fostering innovation and calls for strategic alliances and knowledge sharing to drive circular economy practices. Further research is recommended to understand the barriers to implementing circular economy practices and identify effective solutions. Overall, this paper provides valuable insights for advancing the circular economy in the energy sector and achieving broader sustainability goals.info:eu-repo/semantics/publishedVersio

Impact of carvedilol on the mitochondrial damage induced by hypoxanthine and xantine oxidase: what role in myocardial ischemia and reperfusion?

OBJECTIVES: The cardioprotective effects of carvedilol (CV) may be explained in part by interactions with heart mitochondria. The objective of this work was to study the protection afforded by CV against oxidative stress induced in isolated heart mitochondria by hypoxanthine and xanthine oxidase (HX/XO), a well-known source of reactive oxygen species (ROS) in the cardiovascular system. METHODS: Mitochondria were isolated from Wistar rat hearts (n = 8) and incubated with HX/XO in the presence and in the absence of calcium. Several methods were used to assess the protection afforded by CV: evaluation of mitochondrial volume changes (by measuring changes in the optical density of the mitochondrial suspension), calcium uptake and release (with a fluorescent probe, Calcium Green 5-N) and mitochondrial respiration (with a Clark-type oxygen electrode). RESULTS: CV decreased mitochondrial damage associated with ROS production by HX and XO, as verified by the reduction of mitochondrial swelling and increase in mitochondrial calcium uptake. In the presence of HX and XO, CV also ameliorated mitochondrial respiration in the active phosphorylation state and prevented decrease in the respiratory control ratio (p < 0.05) and in mitochondrial phosphorylative efficiency (p < 0.001). CONCLUSIONS: The data indicate that CV partly protected heart mitochondria from oxidative damage induced by HX and XO, which may be useful during myocardial ischemia and reperfusion. It is also suggested that mitochondria may be a priority target for the protective action of some compounds

Chronic granulomatous disease associated with common variable immunodeficiency - 2 clinical cases

INTRODUCTION: Chronic granulomatous disease associated with common variable immunodeficiency (GD-CVID), although well documented, is rare. Granulomatous lesions can affect several organs and are histologically indistinguishable from sarcoidosis. CLINICAL CASES: Case 1: A 39-year-old male patient with CVID, asymptomatic although with thrombocytopenia and mediastinal-hilar adenopathies. GD-CVID was diagnosed by bone marrow biopsy. Progressive clinical and radiological improvement was obtained with corticotherapy. Case 2: A 38-year-old male patient with CVID, suffered from asthenia, anorexia, myalgia, lower limbs edemas, and dry cough. He had mediastinal and bilateral hilar adenopathies within which biopsy revealed non-necrotizing granulomatous infiltrate. A spontaneous resolution was detected after 9 months of evolution. CONCLUSION: GD-CVID is rare and can mimetize other pathologies, namely, sarcoidosis; it should therefore be publicized and discussed so that it becomes a general clinical knowledge

Statistical analysis of quality control measurements in IMRT for head and neck and prostate cancer

Intensity Modulated Radiotherapy (IMRT) is a technique introduced to shape more precisely the dose distributions to the tumour, providing a higher dose escalation in the volume to irradiate and simultaneously decreasing the dose in the organs at risk which consequently reduces the treatment toxicity. This technique is widely used in prostate and head and neck (H&N) tumours. Given the complexity and the use of high doses in this technique it’s necessary to ensure as a safe and secure administration of the treatment, through the use of quality control programmes for IMRT. The purpose of this study was to evaluate statistically the quality control measurements that are made for the IMRT plans in prostate and H&N patients, before the beginning of the treatment, analysing their variations, the percentage of rejected and repeated measurements, the average, standard deviations and the proportion relations

Mobile sensing system for cycling power output control

This paper describes the development of a novel cycling effort control sys-tem that contributes to promote the users’ physical health and mobility. This system controls the motor assistance level of an electric bicycle in order to ensure that the cyclist’s power output remains inside the desired limits, regardless of changes in variables such as the speed of the bicycle or the slope of the terrain. The power output is monitored using a sensor device that provides raw torque and cadence data, whereas a smartphone application processes these data, implements the effort control algorithm and provides the user interface. Modules on the bicycle handle the data acquisition, wire-less communication with the smartphone and driving of the motor assis-tance level. Experimental results validate the effectiveness of the imple-mented power output control system.This work is supported by FCT (Fundação para a Ciência e Tecnologia) with the reference project UID/EEA/04436/2013, and by FEDER funds through the COMPETE 2020 – Programa Operacional Competitividade e Internacionalização (POCI) with the reference project POCI-01-0145-FEDER-006941

Evidence for the evolutionary steps leading to mecA-mediated ß-lactam resistance in staphylococci

The epidemiologically most important mechanism of antibiotic resistance in Staphylococcus aureus is associated with mecA–an acquired gene encoding an extra penicillin-binding protein (PBP2a) with low affinity to virtually all β-lactams. The introduction of mecA into the S. aureus chromosome has led to the emergence of methicillin-resistant S. aureus (MRSA) pandemics, responsible for high rates of mortality worldwide. Nonetheless, little is known regarding the origin and evolution of mecA. Different mecA homologues have been identified in species belonging to the Staphylococcus sciuri group representing the most primitive staphylococci. In this study we aimed to identify evolutionary steps linking these mecA precursors to the β-lactam resistance gene mecA and the resistance phenotype. We sequenced genomes of 106 S. sciuri, S. vitulinus and S. fleurettii strains and determined their oxacillin susceptibility profiles. Single-nucleotide polymorphism (SNP) analysis of the core genome was performed to assess the genetic relatedness of the isolates. Phylogenetic analysis of the mecA gene homologues and promoters was achieved through nucleotide/amino acid sequence alignments and mutation rates were estimated using a Bayesian analysis. Furthermore, the predicted structure of mecA homologue-encoded PBPs of oxacillin-susceptible and -resistant strains were compared. We showed for the first time that oxacillin resistance in the S. sciuri group has emerged multiple times and by a variety of different mechanisms. Development of resistance occurred through several steps including structural diversification of the non-binding domain of native PBPs; changes in the promoters of mecA homologues; acquisition of SCCmec and adaptation of the bacterial genetic background. Moreover, our results suggest that it was exposure to β-lactams in human-created environments that has driven evolution of native PBPs towards a resistance determinant. The evolution of β-lactam resistance in staphylococci highlights the numerous resources available to bacteria to adapt to the selective pressure of antibiotics

Model predictive control of an on-board fast battery charger for electric mobility applications

Under the necessities of reducing emissions and air pollution, and also for increasing fuel economy, automotive companies have been developing electric and plug-in hybrid electric vehicles. Since these vehicles are parked when the batteries are being charged, it is possible to use the traction power converter as on-board charger, also allowing to reduce weight, volume and costs of components in the vehicle. In this context, this paper presents a model predictive control algorithm for an on-board fast battery charging that uses the traction power converter of an electric vehicle. Simulation results and system implementation are depicted, and finally, are presented some experimental results obtained with the proposed control system.(undefined)info:eu-repo/semantics/publishedVersio

Model predictive control of an on-board fast battery charger for electric mobility applications

Under the necessities of reducing emissions and air pollution, and also for increasing fuel economy, automotive companies have been developing electric and plug-in hybrid electric vehicles. Since these vehicles are parked when the batteries are being charged, it is possible to use the traction power converter as on-board charger, also allowing to reduce weight, volume and costs of components in the vehicle. In this context, this paper presents a model predictive control algorithm for an on-board fast battery charging that uses the traction power converter of an electric vehicle. Simulation results and system implementation are depicted, and finally, are presented some experimental results obtained with the proposed control system.(undefined)info:eu-repo/semantics/publishedVersio

A simplified methodology for parameters measurement of an axial flux permanent magnet motor without neutral point

The recent developments in the area of electric vehicles resulted in the growth of the interest for Axial Flux Permanent Magnet Motors, mainly because of their high power density. For the design of the motor drive it is of extreme importance to have the motor parameters, although many times the manufacturers do not provide them. To overcome this problem, in this paper is presented a methodology to obtain the parameters of this type of motor, in order to make possible the implementation of the d-q model. In synchronous motors with permanent magnets the inductance changes with the rotor position, so the d-q model is used to simplify the analysis and to get a better understanding of the motor parameters. Thus, this paper presents the d-q model of an axial flux permanent magnet synchronous motor with two external stators and one internal rotor.FEDER Funds - Operational Programme for Competitiveness Factors (COMPETE)Fundação para a Ciência e a Tecnologia (FCT) - PTDC/EEA-EEL/104569/2008, MIT-PT/EDAM-SMS/0030/200