Neurobiology and clinical implications of lucid dreaming

Several lines of evidence converge to the idea that rapid eye movement sleep (REMS) is a good model to foster our understanding of psychosis. Both REMS and psychosis course with internally generated perceptions and lack of rational judgment, which is attributed to a hyperlimbic activity along with hypofrontality. Interestingly, some individuals can become aware of dreaming during REMS, a particular experience known as lucid dreaming (LD), whose neurobiological basis is still controversial. Since the frontal lobe plays a role in self-consciousness, working memory and attention, here we hypothesize that LD is associated with increased frontal activity during REMS. A possible way to test this hypothesis is to check whether transcranial magnetic or electric stimulation of the frontal region during REMS triggers LD. We further suggest that psychosis and LD are opposite phenomena: LD as a physiological awakening while dreaming due to frontal activity, and psychosis as a pathological intrusion of dream features during wake state due to hypofrontality. We further suggest that LD research may have three main clinical implications. First, LD could be important to the study of consciousness, including its pathologies and other altered states. Second, LD could be used as a therapy for recurrent nightmares, a common symptom of depression and post-traumatic stress disorder. Finally, LD may allow for motor imagery during dreaming with possible improvement of physical rehabilitation. In all, we believe that LD research may clarify multiple aspects of brain functioning in its physiological, altered and pathological states

Neurobiology and clinical implications of lucid dreaming

Article history: a b s t r a c t Several lines of evidence converge to the idea that rapid eye movement sleep (REMS) is a good model to foster our understanding of psychosis. Both REMS and psychosis course with internally generated perceptions and lack of rational judgment, which is attributed to a hyperlimbic activity along with hypofrontality. Interestingly, some individuals can become aware of dreaming during REMS, a particular experience known as lucid dreaming (LD), whose neurobiological basis is still controversial. Since the frontal lobe plays a role in self-consciousness, working memory and attention, here we hypothesize that LD is associated with increased frontal activity during REMS. A possible way to test this hypothesis is to check whether transcranial magnetic or electric stimulation of the frontal region during REMS triggers LD. We further suggest that psychosis and LD are opposite phenomena: LD as a physiological awakening while dreaming due to frontal activity, and psychosis as a pathological intrusion of dream features during wake state due to hypofrontality. We further suggest that LD research may have three main clinical implications. First, LD could be important to the study of consciousness, including its pathologies and other altered states. Second, LD could be used as a therapy for recurrent nightmares, a common symptom of depression and post-traumatic stress disorder. Finally, LD may allow for motor imagery during dreaming with possible improvement of physical rehabilitation. In all, we believe that LD research may clarify multiple aspects of brain functioning in its physiological, altered and pathological states

Chemistry and antigerminative activity of essential oils and monoterpenoids from Mediterranean plants

The Mediterranean flora is characterized by the abundance of aromatic plants. The feature differentiating these plants from all others, in spite of the fact that they belong to many different families, is the production of chemically related secondary compounds, the low molecular weight and volatile isoprenoids. This remarkable presence of aromatic species is important in determining the allelopathic potential within this ecosystem. Such plants make a significant contribution to phryganic Mediterranean ecosystems both in terms of species number and biomass. Thus, the essential oils play an important role in this ecological context. Mediating various processes in the frame of an ecosystem, they become indirectly beneficial to the plants, considering their involvement in processes of adaptative character in Mediterranean ecosystem . For this reason, our research group carried out a series of studies on the possible allelopathic properties of aromatic plants that, being rich in active principles, are considered a primary source of potential allelochemicals.The focus of this overview is direct to have an overall idea about the chemistry and antigerminative activity of essential oils of some Mediterranean aromatic plants and their main constituent

Flood vulnerability, environmental land use conflicts, and conservation of soil and water: a study in the Batatais SP municipality, Brazil.

In many regions across the planet, flood events are now more frequent and intense because of climate change and improper land use, resulting in risks to the population. However, the procedures to accurately determine the areas at risk in regions influenced by inadequate land uses are still inefficient. In rural watersheds, inadequate uses occur when actual uses deviate from land capability, and are termed environmental land use conflicts. To overcome the difficulty to evaluate flood vulnerability under these settings, in this study a method was developed to delineate flood vulnerability areas in a land use conflict landscape: the Batatais municipality, located in the State of São Paulo, Brazil. The method and its implementation resorted to remote sensed data, geographic information systems and geo-processing. Satellite images and their processing provided data for environmental factors such as altitude, land use, slope, and soil class in the study area. The importance of each factor for flood vulnerability was evaluated through the analytical hierarchy process (AHP). According to the results, vast areas of medium to high flood vulnerability are located in agricultural lands affected by environmental land use conflicts. In these areas, amplified flood intensities, soil erosion, crop productivity loss and stream water deterioration are expected. The coverage of Batatais SP municipality by these vulnerable areas is so extensive (60%) that preventive and recovery measures were proposed in the context of a land consolidation-water management plan aiming flood control and soil and water conservation

Terapêutica intravesical com bacilo de Calmette-Guérin no tratamento do carcinoma da bexiga / o que sabemos até agora

AbstractIntroductionThe use of intravesical Bacillus Calmette-Guérin is a valid option in the treatment of non-muscle invasive bladder tumors, making it the main subject of a lot of publications. The aim of the present study is to review and consolidate the data available about this subject.MethodsA review of the data available was made on PubMed with the keywords: “intravesical BCG” and “non-muscle invasive bladder cancer”. Original and review articles written in English or Portuguese were selected. We present the discussion alongside the results for structural purposes.Results and discussionScientific evidence strongly advises in favor of BCG use on intermediate and high risk tumors, due to its impact on the recurrence and possibly on the progression rates. It is important to be watchful for possible local and systemic side effects, that when detected call for a rightful therapeutically decision alongside the recommended schemes.ConclusionThe use of intravesical BCG with therapeutically purposes has strong evidence on the non-muscle invasive bladder tumors. More studies are needed in order to better understand the best administration scheme and its mechanism of action

Zoneamento agroecológico do Município de Acrelândia, Estado do Acre.

O objetivo deste estudo foi o de suprir a falta de dados relacionados aos recursos naturais regionais, visando apresentar aos orgãos de interesse agronômico, subsídios necessários a um melhor planejamento voltado a sustentabildiade municipal através de seu Zoneamento Agroecológico. São indicadas neste trabalho, áreas para uso sustentável de atividades com lavoura, pecuária e preservação ambiental, caracterizando seus solos quanto sua pontencialidade e suas limitações, visando também projetos de colonização, expansão urbana e infra-estrutura viária para ativar a potencialidade das produçóes de culturas alimentares e industriais.bitstream/item/63940/1/Oriental-Doc205.pd

Modelagem fuzzy para previsão da produtividade de goiabeira 'Paluma' em sistema agroindustrial em função da época de poda e do estado nutricional.

Abstract. As incertezas inerentes ao processo de produção de goiaba Paluma, principalmente quando se considera a época de poda e a avaliação do estado nutricional das plantas, podem interferir nos ganhos do fruticultor, pois a adubação representa boa parte dos custos de produção. Neste trabalho, apresentamos um modelo fuzzy para estimar a produtividade da goiabeira Paluma incorporando ao modelo as incertezas nos teores foliares de NPK e a época da poda. Consideraram-se nas relações fuzzy as tabelas de suficiência dos nutrientes e a experiência dos pesquisadores e produtores. O controlador fuzzy foi bem sucedido na tarefa de predizer a produtividade da goiabeira. Os resultados estimados quando comparados com os observados no campo apresentaram erro inferior a 10% para a maioria das amostras analisadas

Intrinsic aerobic capacity sets a divide for aging and longevity

<p><b>Rationale:</b> Low aerobic exercise capacity is a powerful predictor of premature morbidity and mortality for healthy adults as well as those with cardiovascular disease. For aged populations, poor performance on treadmill or extended walking tests indicates closer proximity to future health declines. Together, these findings suggest a fundamental connection between aerobic capacity and longevity.</p> <p><b>Objectives:</b> Through artificial selective breeding, we developed an animal model system to prospectively test the association between aerobic exercise capacity and survivability (aerobic hypothesis).</p> <p><b>Methods and Results:</b> Laboratory rats of widely diverse genetic backgrounds (N:NIH stock) were selectively bred for low or high intrinsic (inborn) treadmill running capacity. Cohorts of male and female rats from generations 14, 15, and 17 of selection were followed for survivability and assessed for age-related declines in cardiovascular fitness including maximal oxygen uptake (VO<sub>2max</sub>), myocardial function, endurance performance, and change in body mass. Median lifespan for low exercise capacity rats was 28% to 45% shorter than high capacity rats (hazard ratio, 0.06; P<0.001). VO<sub>2max</sub>, measured across adulthood was a reliable predictor of lifespan (P<0.001). During progression from adult to old age, left ventricular myocardial and cardiomyocyte morphology, contractility, and intracellular Ca<sup>2+</sup> handling in both systole and diastole, as well as mean blood pressure, were more compromised in rats bred for low aerobic capacity. Physical activity levels, energy expenditure (Vo<sub>2</sub>), and lean body mass were all better sustained with age in rats bred for high aerobic capacity.</p> <p><b>Conclusions:</b> These data obtained from a contrasting heterogeneous model system provide strong evidence that genetic segregation for aerobic exercise capacity can be linked with longevity and are useful for deeper mechanistic exploration of aging.</p&gt