Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals, and systematic attempts to identify linkage in multiplex families have confirmed that variation within the major histocompatibility complex (MHC) exerts the greatest individual effect on risk. Modestly powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility. Most of the genetic architecture underlying susceptibility to the disease remains to be defined and is anticipated to require the analysis of sample sizes that are beyond the numbers currently available to individual research groups. In a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, we have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci. Within the MHC we have refined the identity of the HLA-DRB1 risk alleles and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. Immunologically relevant genes are significantly overrepresented among those mapping close to the identified loci and particularly implicate T-helper-cell differentiation in the pathogenesis of multiple sclerosis

Edessa amazonica Fernandes & Doesburg, 2000, espèce nouvelle pour la Guyane française et le Suriname, et première description de la femelle (Hemiptera, Pentatomidae, Edessinae)

Edessa amazonica Fernandes & Doesburg, 2000, first mention in French Guiana and Surinam, and first description of the female (Hemiptera, Pentatomidae, Edessinae). The holotype of Edessa amazonica was not collected in French Guiana but in Surinam. Then, this species is new for Surinam, as well as for French Guiana since four specimens of E. amazonica were recently discovered there, including one female photographed and described for the first time. Amazonian geographical distribution of the three closely related species Edessa beckeri, E. xingu and E. amazonica, is updated, as well as the distribution of E. amazonica in French Guiana.L’holotype d’Edessa amazonica ne provient pas de Guyane française mais du Suriname. L’espèce est ainsi nouvelle pour le Suriname, mais également pour la Guyane française car quatre exemplaires d’E. amazonica y ont récemment été découverts, dont une femelle photographiée et décrite pour la première fois. La distribution géographique en Amazonie des trois espèces proches Edessa beckeri, E. xingu et E. amazonica, est mise à jour, ainsi que celle d’E. amazonica en Guyane.Lupoli Roland. Edessa amazonica Fernandes & Doesburg, 2000, espèce nouvelle pour la Guyane française et le Suriname, et première description de la femelle (Hemiptera, Pentatomidae, Edessinae). In: Bulletin de la Société entomologique de France, volume 122 (2),2017. pp. 199-202

Recherches sur la caracterisation intraspecifique moleculaire et biologique des pucerons en vue de son application a l'epidemiologie des virus de type non persistant

SIGLEINIST T 76349 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

First catalogue of the Asopinae (Hemiptera, Pentatomidae) from French Guiana

Lupoli, Roland (2019): First catalogue of the Asopinae (Hemiptera, Pentatomidae) from French Guiana. Zootaxa 4668 (1): 76-88, DOI: https://doi.org/10.11646/zootaxa.4668.1.

Edessa amazonica Fernandes & Doesburg, 2000, espèce nouvelle pour la Guyane française et le Suriname, et première description de la femelle (Hemiptera, Pentatomidae, Edessinae)

Edessa amazonica Fernandes & Doesburg, 2000, first mention in French Guiana and Surinam, and first description of the female (Hemiptera, Pentatomidae, Edessinae). The holotype of Edessa amazonica was not collected in French Guiana but in Surinam. Then, this species is new for Surinam, as well as for French Guiana since four specimens of E. amazonica were recently discovered there, including one female photographed and described for the first time. Amazonian geographical distribution of the three closely related species Edessa beckeri, E. xingu and E. amazonica, is updated, as well as the distribution of E. amazonica in French Guiana.L’holotype d’Edessa amazonica ne provient pas de Guyane française mais du Suriname. L’espèce est ainsi nouvelle pour le Suriname, mais également pour la Guyane française car quatre exemplaires d’E. amazonica y ont récemment été découverts, dont une femelle photographiée et décrite pour la première fois. La distribution géographique en Amazonie des trois espèces proches Edessa beckeri, E. xingu et E. amazonica, est mise à jour, ainsi que celle d’E. amazonica en Guyane.Lupoli Roland. Edessa amazonica Fernandes & Doesburg, 2000, espèce nouvelle pour la Guyane française et le Suriname, et première description de la femelle (Hemiptera, Pentatomidae, Edessinae). In: Bulletin de la Société entomologique de France, volume 122 (2),2017. pp. 199-202

A practical test to assess the potential of dissemination of a non-persistent aphid-borne virus from an infected plant

National audienc

La mesure du taux de transmission d'un virus non-persistant par puceron. Definition d'un test pratique et application a l'etude du comportement de 2 souches du virus des taches en anneau du papayer (PRSV)

National audienc

The transmissibility of a potyvirus by an aphid vector : reliability of measurements under controlled conditions

International audienc

Un Hémiptère nouveau en Europe : Ventocoris martini (Horváth, 1889) (Het., Pentatomidae)

Lupoli Roland, Dusoulier François, Streito Jean-Claude, Foucart Antoine. Un Hémiptère nouveau en Europe : Ventocoris martini (Horváth, 1889) (Het., Pentatomidae). In: Bulletin de la Société entomologique de France, volume 112 (1), mars 2007. pp. 15-16