406 research outputs found
Effects of Reflection and Refraction of Ultrasonic Waves on the Angle Beam Inspection of Anisotropic Composite Material
Nondestructive testing of composite materials by ultrasonic techniques has several specific features resulting from strong material anisotropy and inhomogeneity. This requires reexamination of old testing methodologies and development of new ones. The latest developments in this direction were recently reviewed by Henneke and Duke [1] and by Bar-Cohen [2]
Anomalous absorption of bulk shear sagittal acoustic waves in a layered structure with viscous fluid
It is demonstrated theoretically that the absorptivity of bulk shear sagittal
waves by an ultra-thin layer of viscous fluid between two different elastic
media has a strong maximum (in some cases as good as 100%) at an optimal layer
thickness. This thickness is usually much smaller than the penetration depths
and lengths of transverse and longitudinal waves in the fluid. The angular
dependencies of the absorptivity are demonstrated to have significant and
unusual structure near critical angles of incidence. The effect of
non-Newtonian properties and non-uniformities of the fluid layer on the
absorptivity is also investigated. In particular, it is shown that the
absorption in a thin layer of viscous fluid is much more sensitive to non-zero
relaxation time(s) in the fluid layer than the absorption at an isolated
solid-fluid interface.Comment: 14 pages, 8 figure
Modeling for Ultrasonic Health Monitoring of Foams with Embedded Sensors
In this report analytical and numerical methods are proposed to estimate the effective elastic properties of regular and random open-cell foams. The methods are based on the principle of minimum energy and on structural beam models. The analytical solutions are obtained using symbolic processing software. The microstructure of the random foam is simulated using Voronoi tessellation together with a rate-dependent random close-packing algorithm. The statistics of the geometrical properties of random foams corresponding to different packing fractions have been studied. The effects of the packing fraction on elastic properties of the foams have been investigated by decomposing the compliance into bending and axial compliance components. It is shown that the bending compliance increases and the axial compliance decreases when the packing fraction increases. Keywords: Foam; Elastic properties; Finite element; Randomnes
Effect of multiaxial forging on microstructure and mechanical properties of Mg-0.8Ca alloy
It was shown that multiaxial forging with continuous decrease of temperature from 450°C to 250°C turns coarse structure of the Mg-0.8Ca alloy in homogenized state with grain size of several hundreeds μm into fine structure with average grain size of about 2.1 μm. Refinement of structure is accompanied by drastic increase of mechanical properties: tensile yield strength increases from 50 MPa to 193 MPa, ultimate tensile strength increases from 78 to 308 MPa and elongation to fracture increases from 3.0% to 7.2%. The microstructural evolution during multiaxial forging is studied using optical microscopy, scanning electron microscopy and EBSD analysis. The mechanisms responsible for refinement of microstructure are discusse
Scattering in flatland: Efficient representations via wave atoms
This paper presents a numerical compression strategy for the boundary
integral equation of acoustic scattering in two dimensions. These equations
have oscillatory kernels that we represent in a basis of wave atoms, and
compress by thresholding the small coefficients to zero. This phenomenon was
perhaps first observed in 1993 by Bradie, Coifman, and Grossman, in the context
of local Fourier bases \cite{BCG}. Their results have since then been extended
in various ways. The purpose of this paper is to bridge a theoretical gap and
prove that a well-chosen fixed expansion, the nonstandard wave atom form,
provides a compression of the acoustic single and double layer potentials with
wave number as -by- matrices with
nonnegligible entries, with a constant that depends on the relative
accuracy \eps in an acceptable way. The argument assumes smooth, separated,
and not necessarily convex scatterers in two dimensions. The essential features
of wave atoms that enable to write this result as a theorem is a sharp
time-frequency localization that wavelet packets do not obey, and a parabolic
scaling wavelength (essential diameter). Numerical experiments
support the estimate and show that this wave atom representation may be of
interest for applications where the same scattering problem needs to be solved
for many boundary conditions, for example, the computation of radar cross
sections.Comment: 39 page
Complexity Analysis of a Fast Directional Matrix-Vector Multiplication
We consider a fast, data-sparse directional method to realize matrix-vector
products related to point evaluations of the Helmholtz kernel. The method is
based on a hierarchical partitioning of the point sets and the matrix. The
considered directional multi-level approximation of the Helmholtz kernel can be
applied even on high-frequency levels efficiently. We provide a detailed
analysis of the almost linear asymptotic complexity of the presented method.
Our numerical experiments are in good agreement with the provided theory.Comment: 20 pages, 2 figures, 1 tabl
Computational Physics on Graphics Processing Units
The use of graphics processing units for scientific computations is an
emerging strategy that can significantly speed up various different algorithms.
In this review, we discuss advances made in the field of computational physics,
focusing on classical molecular dynamics, and on quantum simulations for
electronic structure calculations using the density functional theory, wave
function techniques, and quantum field theory.Comment: Proceedings of the 11th International Conference, PARA 2012,
Helsinki, Finland, June 10-13, 201
Validation through comparison: Measurement and calculation of the bistatic radar cross section of a stealth target
Polynomial diffeomorphisms of C^2, IV: The measure of maximal entropy and laminar currents
This paper concerns the dynamics of polynomial automorphisms of .
One can associate to such an automorphism two currents and the
equilibrium measure . In this paper we study some
geometric and dynamical properties of these objects. First, we characterize
as the unique measure of maximal entropy. Then we show that the measure
has a local product structure and that the currents have a
laminar structure. This allows us to deduce information about periodic points
and heteroclinic intersections. For example, we prove that the support of
coincides with the closure of the set of saddle points. The methods used
combine the pluripotential theory with the theory of non-uniformly hyperbolic
dynamical systems
Novel HTS Strategy Identifies TRAIL-Sensitizing Compounds Acting Specifically Through the Caspase-8 Apoptotic Axis
Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) is potentially a very important therapeutic as it shows selectivity for inducing apoptosis in cancer cells whilst normal cells are refractory. TRAIL binding to its cognate receptors, Death Receptors-4 and -5, leads to recruitment of caspase-8 and classical activation of downstream effector caspases, leading to apoptosis. As with many drugs however, TRAIL's usefulness is limited by resistance, either innate or acquired. We describe here the development of a novel 384-well high-throughput screening (HTS) strategy for identifying potential TRAIL-sensitizing agents that act solely in a caspase-8 dependent manner. By utilizing a TRAIL resistant cell line lacking caspase-8 (NB7) compared to the same cells reconstituted with the wild-type protein, or with a catalytically inactive point mutant of caspase-8, we are able to identify compounds that act specifically through the caspase-8 axis, rather than through general toxicity. In addition, false positive hits can easily be “weeded out” in this assay due to their activity in cells lacking caspase-8-inducible activity. Screening of the library of pharmacologically active compounds (LOPAC) was performed as both proof-of-concept and to discover potential unknown TRAIL sensitizers whose mechanism is caspase-8 mediated. We identified known TRAIL sensitizers from the library and identified new compounds that appear to sensitize specifically through caspase-8. In sum, we demonstrate proof-of-concept and discovery of novel compounds with a screening strategy optimized for the detection of caspase-8 pathway-specific TRAIL sensitizers. This screen was performed in the 384-well format, but could easily be further miniaturized, allows easy identification of artifactual false positives, and is highly scalable to accommodate diverse libraries
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