401 research outputs found
Is Aggressive Surgical Palliation of Proximal Bile Duct Cancer With Involvement of Both Main Hepatic Ducts Worthwhile?
The only curative treatment for proximal bile duct cancer with involvement of both main hepatic ducts is
liver transplantation. Most patients do not fulfill the requirements for liver transplantation. Our
treatment strategy in appropriate cases is palliative tumor resection and reconstruction of the biliary
passage by sutureless bilioenteric anastomosis. We have treated 12 patients, 5 in combination with
intraluminal and percutaneous radiotherapy. Our results indicate that this strategy leads to effective
palliation in some cases provided that only microscopic residual tumor is left in-situ. Our survival times
compare favourably with survival after liver transplantation
Characterizing Exoplanets in the Visible and Infrared: A Spectrometer Concept for the EChO Space Mission
Transit-spectroscopy of exoplanets is one of the key observational techniques
to characterize the extrasolar planet and its atmosphere. The observational
challenges of these measurements require dedicated instrumentation and only the
space environment allows an undisturbed access to earth-like atmospheric
features such as water or carbon-dioxide. Therefore, several exoplanet-specific
space missions are currently being studied. One of them is EChO, the Exoplanet
Characterization Observatory, which is part of ESA's Cosmic Vision 2015-2025
program, and which is one of four candidates for the M3 launch slot in 2024. In
this paper we present the results of our assessment study of the EChO
spectrometer, the only science instrument onboard this spacecraft. The
instrument is a multi-channel all-reflective dispersive spectrometer, covering
the wavelength range from 400 nm to 16 microns simultaneously with a moderately
low spectral resolution. We illustrate how the key technical challenge of the
EChO mission - the high photometric stability - influences the choice of
spectrometer concept and drives fundamentally the instrument design. First
performance evaluations underline the fitness of the elaborated design solution
for the needs of the EChO mission.Comment: 20 pages, 8 figures, accepted for publication in the Journal of
Astronomical Instrumentatio
PANIC: the new panoramic NIR camera for Calar Alto
PANIC is a wide-field NIR camera, which is currently under development for
the Calar Alto observatory (CAHA) in Spain. It uses a mosaic of four Hawaii-2RG
detectors and covers the spectral range from 0.8-2.5 micron(z to K-band). The
field-of-view is 30x30 arcmin. This instrument can be used at the 2.2m
telescope (0.45arcsec/pixel, 0.5x0.5 degree FOV) and at the 3.5m telescope
(0.23arcsec/pixel, 0.25x0.25 degree FOV). The operating temperature is about
77K, achieved by liquid Nitrogen cooling. The cryogenic optics has three flat
folding mirrors with diameters up to 282 mm and nine lenses with diameters
between 130 mm and 255 mm. A compact filter unit can carry up to 19 filters
distributed over four filter wheels. Narrow band (1%) filters can be used. The
instrument has a diameter of 1.1 m and it is about 1 m long. The weight limit
of 400 kg at the 2.2m telescope requires a light-weight cryostat design. The
aluminium vacuum vessel and radiation shield have wall thicknesses of only 6 mm
and 3 mm respectively.Comment: This paper has been presented in the SPIE of Astronomical Telescopes
and Instrumentation 2008 in Marseille (France
GRAVITY: getting to the event horizon of Sgr A*
We present the second-generation VLTI instrument GRAVITY, which currently is
in the preliminary design phase. GRAVITY is specifically designed to observe
highly relativistic motions of matter close to the event horizon of Sgr A*, the
massive black hole at center of the Milky Way. We have identified the key
design features needed to achieve this goal and present the resulting
instrument concept. It includes an integrated optics, 4-telescope, dual feed
beam combiner operated in a cryogenic vessel; near infrared wavefront sensing
adaptive optics; fringe tracking on secondary sources within the field of view
of the VLTI and a novel metrology concept. Simulations show that the planned
design matches the scientific needs; in particular that 10 microarcsecond
astrometry is feasible for a source with a magnitude of K=15 like Sgr A*, given
the availability of suitable phase reference sources.Comment: 13 pages, 11 figures, to appear in the conference proceedings of SPIE
Astronomical Instrumentation, 23-28 June 2008, Marseille, Franc
Modification of a conventional photolytic converter for improving aircraft measurements of NO via chemiluminescence
Nitrogen oxides (NO≡NO+NO) are centrally involved in the photochemical processes taking place in the Earth\u27s atmosphere. Measurements of NO, particularly in remote areas where concentrations are of the order of parts per trillion by volume (pptv), are still a challenge and subject to extensive research. In this study, we present NO measurements via photolysis–chemiluminescence during the research aircraft campaign CAFE Africa (Chemistry of the Atmosphere – Field Experiment in Africa) 2018 around Cabo Verde and the results of laboratory experiments to characterize the photolytic converter used. We find the NO reservoir species MPN (methyl peroxy nitrate) to produce the only relevant thermal interference in the converter under the operating conditions during CAFE Africa. We identify a memory effect within the conventional photolytic converter (type 1) associated with high NO concentrations and rapidly changing water vapor concentrations, accompanying changes in altitude during aircraft measurements, which is due to the porous structure of the converter material. As a result, NO artifacts, which are amplified by low conversion efficiencies, and a varying instrumental background adversely affect the NO measurements. We test and characterize an alternative photolytic converter (type 2) made from quartz glass, which improves the reliability of NO measurements in laboratory and field studies
Calcium Uptake and Proton Transport by Acidocalcisomes of Toxoplasma gondii
Acidocalcisomes are acidic calcium stores found in diverse organisms, being conserved from bacteria to humans. They possess an acidic matrix that contains several cations bound to phosphates, which are mainly present in the form of short and long polyphosphate chains. Their matrix is acidified through the action of proton pumps such as a vacuolar proton ATPase and a vacuolar proton pyrophosphatase. Calcium uptake occurs through a Ca2+/H+ countertransporting ATPase located in the membrane of the organelle. Acidocalcisomes have been identified in a variety of microorganisms, including Apicomplexan parasites such as Plasmodium and Eimeria species, and in Toxoplasma gondii. We report the purification and characterization of an acidocalcisome fraction from T. gondii tachyzoites after subcellular fractionation and further discontinuous iodixanol gradient purification. Proton and calcium transport activities in the fraction were characterized by fluorescence microscopy and spectrophotometric methods using acridine orange and arsenazo III, respectively. This work will facilitate the understanding of the function of acidocalcisomes in Apicomplexan parasites, as we can now isolate highly purified fractions that could be used for proteomic analysis to find proteins that may clarify the biogenesis of these organelles
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