Regional differences in cancer incidence trend in tehran, Iran: A contextual study on the effect of socioeconomic status at regional level

Background: Cancer is a major public health concern all over the world. The aim of the current study is to demonstrate changing trends of cancer incidence from 2006 to 2009 in Tehran (capital city of Iran) and evaluate the effect of living in different regions according to their median socioeconomic status (SES) on cancer cumulative incidence. Methods: The incident cases were obtainedfromthe population based cancer register of ministry of healthandmedicine in Iran; we examined the annual percent changes (APCs) and overall trends of total cancer incidence across regions in Tehran. The age and sex standardized incidence rates were computed by the direct method. Poisson regression and negative binominal regression model were used to assess the existence of trends across 4 consecutive years, as well as the effect of living in each region, literacy rate, and employment rate across regions on this trend. All the analyses were done by Stata 12.0 software. Results: The findings of this study showed downward and nonlinear trend during 4 years. The age-standardized incidence rate (ASR) was higher in men compared to women in this period. ASRs for overall 4 years were 114 and 101 per 10,0000 men and women, respectively. Average annual percent change based on ASR and regression model for each sex was the same and around -5 and -6, respectively. Incidence rate also differed between districts so that north and center districts had higher incidence than southern parts in both sexes. The lowest rate ratio attributed to district 17 and 18 located in south of Tehran and the highest rate ratio attributed to district 6 for each sex compared to the baseline district 16. Results reported the sharp increase of 59 and 37 in district 6 compared to district 16 in men and women, respectively. Better regional social status increased the risk of cancer among women. Also, the results showed a partially significant interaction with higher decrease in annual trend of cancer rate in socially more deprived regions. Conclusions: The results showeddownwardand nonlinear decreasing trend during 4 years, especially in regions with lower socioeconomic status. Incidence rate also differed between districts so that northern regions had higher incidence than southern regions. Spatio-temporal Analysis of these cancer rates with adjustment for more regional socio-economic characteristicsmaybetter explain the disparities in rate of cancer in different districts across time. © 2018, Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences

Highly heterogeneous probiotic Lactobacillus species in healthy iranians with low functional activities

Background Lactic acid bacteria (LAB) have been considered as potentially probiotic organisms due to their potential human health properties. This study aimed to evaluate both in vitro and in vivo, the potential probiotic properties of Lactobacillus species isolated from fecal samples of healthy humans in Iran. Methods and Results A total of 470 LAB were initially isolated from 53 healthy individual and characterized to species level. Of these, 88 (86) were Lactobacillus species. Biochemical and genetic fingerprinting with Phene-Plate system (PhP-LB) and RAPD-PCR showed that the isolates were highly diverse consisted of 67(76.1) and 75 (85.2) single types (STs) and a diversity indices of 0.994 and 0.997, respectively. These strains were tested for production of adhesion to Caco-2 cells, antibacterial activity, production of B12, anti-proliferative effect and interleukin-8 induction on gut epithelial cell lines and antibiotic resistance against 9 commonly used antibiotics. Strains showing the characteristics consistent with probiotic strains, were further tested for their anti-inflammatory effect in mouse colitis model. Only one L. brevis; one L. rhamnosus and two L. plantarum were shown to have significant probiotic properties. These strains showed shortening the length of colon compared to dextran sulfate sodium and disease activity index (DAI) was also significantly reduced in mouse. Conclusion Low number of LAB with potential probiotic activity as well as high diversity of lactobacilli species was evident in Iranian population. It also suggest that specific strains of L. plantarum, L. brevis and L. rhamnosus with anti-inflammatory effect in mouse model of colitis could be used as a potential probiotic candidate in inflammatory bowel disease to decrease the disease activity index. © 2015 Rohani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Study algicidial activity of 6 species (of) seaweed from Persian Gulf on growth (of) Cochlodinium polykrikoides

Harmful algal blooms resulting in red discoloration of coastal waters in the Persian Gulf, Iran were first observed in January 2007. The species responsible for the bloom, which was identified as Cochlodinium polykrikoides, coincided with massive aquatic organisms’ mortalities in the Persian Gulf. The effects of water soluble extract (0.2, 0.6, 0.8 and 1.6 g L-1) from 6 species of marine macroalgae; Ulva lactuca, Enthromorpha intistialis, Colpomenia sinuosa, Sargassum illicifolium, Gracilaria corticat and Hypnea valentiea , fresh thallus (2.5 and 5.0 g L-1) and macroalgal culture medium filtrate from 3species of marine macroalgae; E.intistialis, C.sinuosa, and H.valentiea on growth of Cochlodinium polkrikoides (Dinoflagellate) were investigated for 15 days in co-culture under controlled laboratory conditions. The results clearly showed that the growth of C. polkrikoides was significantly inhibited by the water-soluble extracts of seaweed at relatively all concentrations in contrast to control with any seaweeds extract (p<0.05). The growth inhibition of C. polykrikoides was significantly higher in co-culture with fresh thallus of E.intistialis, C.sinuosa and H.valentiea (p<0.05). In macroalgal culture medium filtrate the highest growth inhibition of C. polykrikoides was obtained in co-culture with E.intistialis and was significantly higher than the other macroalgal culture medium filtrate of seaweeds(p<0.05). Therefore, we could conclude that using the tested seaweeds either as an extract or in co-culture with fresh thallus could be used as an alternative to biological control of C. polykrikoides

Regional differences in cancer incidence trend in tehran, Iran: A contextual study on the effect of socioeconomic status at regional level

Background: Cancer is a major public health concern all over the world. The aim of the current study is to demonstrate changing trends of cancer incidence from 2006 to 2009 in Tehran (capital city of Iran) and evaluate the effect of living in different regions according to their median socioeconomic status (SES) on cancer cumulative incidence. Methods: The incident cases were obtainedfromthe population based cancer register of ministry of healthandmedicine in Iran; we examined the annual percent changes (APCs) and overall trends of total cancer incidence across regions in Tehran. The age and sex standardized incidence rates were computed by the direct method. Poisson regression and negative binominal regression model were used to assess the existence of trends across 4 consecutive years, as well as the effect of living in each region, literacy rate, and employment rate across regions on this trend. All the analyses were done by Stata 12.0 software. Results: The findings of this study showed downward and nonlinear trend during 4 years. The age-standardized incidence rate (ASR) was higher in men compared to women in this period. ASRs for overall 4 years were 114 and 101 per 10,0000 men and women, respectively. Average annual percent change based on ASR and regression model for each sex was the same and around -5 and -6, respectively. Incidence rate also differed between districts so that north and center districts had higher incidence than southern parts in both sexes. The lowest rate ratio attributed to district 17 and 18 located in south of Tehran and the highest rate ratio attributed to district 6 for each sex compared to the baseline district 16. Results reported the sharp increase of 59 and 37 in district 6 compared to district 16 in men and women, respectively. Better regional social status increased the risk of cancer among women. Also, the results showed a partially significant interaction with higher decrease in annual trend of cancer rate in socially more deprived regions. Conclusions: The results showeddownwardand nonlinear decreasing trend during 4 years, especially in regions with lower socioeconomic status. Incidence rate also differed between districts so that northern regions had higher incidence than southern regions. Spatio-temporal Analysis of these cancer rates with adjustment for more regional socio-economic characteristicsmaybetter explain the disparities in rate of cancer in different districts across time. © 2018, Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences

Evaluation of near final height in boys with constitutional delay in growth and puberty

Background: This study was conducted to find out whether boys with constitutional delay in growth and puberty (CDGP) could attain their target height and predicted adult height (PAH) in adulthood or not. Methods: After measuring the height, weight, pubertal stage, parental height and bone age data of the patients at their first presentation were extracted from the files and their height and weight were measured at the end of the study, wrist X-Ray was performed in order to determine the bone age. PAH was calculated using Bayley-Pinneau method and target height was estimated by mid parental height. Final or near final heights of the patients were measured and compared with the target height and PAH. Results: The mean age at presentation and the end of study was 15.2 ± 0.95, 20 ± 0.75 years respectively. Mean of bone age at the beginning of study was 12.97 ± 1 years and at the end of study were 17.6 ± 0.58 years. Mean of delayed bone age was 2.2 ± 0.82 years. Mean of the primary measured heights was 150.16 ± 7 cm (138-160 cm). Mean of final or near final heights was 165.7 ± 2.89 cm (161-170.5 cm). Final or near final heights in our subjects were smaller than either their PAH (165.7 ± 2.89 vs 170.7 ± 5.17) (P value <0.005) or target height (165.7 ± 2.89 vs 171.8 ± 4.65) (P value <0.0001). Conclusion: Most patients with CDGP do not reach their target height or predicted adult height; they are usually shorter than their parents and general population. Such patients need to be followed up until they reach their final height and, in some cases, adjunctive medical treatment might be indicated. © 2018 The authors

Screening for probiotic characters in lactobacilli isolated from chickens revealed the intra-species diversity of Lactobacillus brevis

Considering the importance of the poultry industry and the increasing interest in alternative growth promoters, probiotics are considered as a potential candidate for use in the poultry industry. In this study, Lactobacillus species were isolated from 21 rectal swabs of 11 healthy 6-day-old and 10 healthy 21-day-old chickens and their fecal and feed samples. The isolates were characterized and their probiotic characteristics, including resistance to gastric acid and bile salts, biofilm formation and adherence to epithelium or mucus, amylase and protease activity and production of inhibitory compounds, were assessed. From 31 acid and bile resistant lactobacilli, only 2 Lactobacillus brevis and 1 Lactobacillus reuteri strains showed significant probiotic properties. These isolates indicated detectable attachment to Caco-2 cells and significant antibacterial activities against Gram-positive and Gram-negative pathogens. Additionally, phenotypic and genotypic diversity of lactobacilli isolates were studied by Phene Plate (PhP) system (PhP-LB) and random amplified polymorphic DNA (RAPD)-PCR, respectively. PhP-LB results of 24 L. brevis isolates showed a high phenotypic variation among the isolates. In comparison, results of RAPD-PCR highlighted a low diversity. Therefore, it seems that combination of the 2 techniques (PhP and RAPD-PCR) could result in a significant discriminatory power than each of them used alone. © 2021 Chinese Association of Animal Science and Veterinary Medicin

Mutation analysis of Phenylalanine hydroxylase gene in Iranian patients with Phenylketonuria

Background: Phenylketonuria as the most common genetic metabolic disorder is the result of disruption of the phenylalanine hydroxylase gene. This study was carried out to explore the phenylalanine hydroxylase gene mutation status of Iranian phenylketonuria patients. Methods: Blood samples were collected from 30 patients, and hot spot areas of the phenylalanine hydroxylase gene, including exons 6, 7, 8, 11, and 12 were studied through polymerase chain reaction and sequencing techniques. Results: Eight different mutations, including 5 missense mutations, 1 splice mutation, 1 nonsense mutation, and 1 Silent/Splice mutation were detected. These mutations were R243X, R261Q, R261X, P281L, R241C, V399V, E280K, and IVS11+1G > C. V399V and R241C were reported for the first time in Iranian population. Three polymorphisms including Q232Q, V245V and L385L and 3 novel intronic variants including IVS10-15A > C, IVS6+44T > G, and IVS6+36 T > G were also detected in this study. Conclusion: The results of this study prove the heterogeneous status of phenylalanine hydroxylase gene mutations in the Iranian population, which can be useful in carrier testing and genetic counseling. © Iran University of Medical Sciences

Screening for efficient nitrogen sources for overproduction of the biomass of the functionally probiotic L. plantarum strain RPR42 in a cane molasses-based medium

Nitrogen source has a vital role for the efficient growth of lactobacilli. The effects of cheese whey, corn steep liquor, and wheat germ extract on the growth of L. plantarum strain RPR42 in cane molasses-based media was evaluated using various approaches of design of experiments. Our results showed that such protein-rich agricultural by-products significantly increase the biomass production of the strain RPR42 in cane molasses-based media. The most affecting nitrogenous material was cheese whey followed by CSL and the minor effect was reported for wheat germ extract as revealed in factorial and Box�Behnken design experiments. The replacement of costly beef extract and yeast extract with a defined mixtures of the above nitrogenous agricultural by-products in cane molasses-based medium led to production of up to 12.64 g/L/24 h of dry biomass of strain RPR42. A detectable cell density of strain RPR42 (~ 9.81 � 109 CFU/mL 24 h) which was observed in such an economic medium showed that the large-scale production of the strain RPR42 tend to be feasible at significantly low costs. © 2020, The Author(s)

A study on distribution and biomass estimination of seaweeds in coastal and its islands

Distribution and biomass of seaweeds in the Persian Gulf and its islands were assessed monthly during low tide from July 2001 to August 2003. Ten stations were defined in the study area and random spots along a transect vertical to the coastline were selected to carry out the sampling. Six stations were located in the coastal waters and four others were close to the islands. Samples were taken in quadrats 0.25 square meter in size (0.5mx0.5m). As a result, 77 species belonging to 4 division of seaweeds were identified. Rhodophyta was represented by 38 species, Chlorophyta had 21 species followed by 17 species of Phaeophyta and only I species of Cyanophyta. The highest and lowest seaweed diversity was seen around Larak Island and Michael station with 74 and 31 species respectively. Although some species such as Gracilaria corticata, Gelidiella acerosa, Laurencia snyderia, Colpomenia sinousa, Padina australis and Diciyosphaeria covernosa were abundant in all stations during the study, some species were absent from some stations. Thrbinaria conoiedes was only seen in Larak island, Spatoglassum variable and Steochospermum marginatum were present only in Larak and Qeshem islands, Codium papilatum and Ulva spp. were spotted only in Larak and Hormoz islands, and Sargassum ilicifolium was detected only in Bandar Lengeh, Shiyo, Larak and Qeshem islands. The maximum and minimum algal biomass (wet weight) was recorded in Bandar Lengeh with 1.058gram^2 and Qeshem island with 391gram'2 and there was significant difference between the two stations (P<0.05). Also the maximum algal biomass was recorded in summer (1466gr.m^2) in Tahoneh-Gorzeh and the minimum biomass (130gram^2) in Qeshem islands. The highest biomass was recorded for the brown algae division (824gram^2) in Bandar Lengeh and the minimum biomass was seen for the green algae division (26gram^2) in Hormoz. and Qeshm islands. The maximum biomass was 755gram in summer for red algae, 1160gram^-2 in Spring for brown algae and 519gram^2 in Summer for green algae

Determination of technical regulation & criteria of Iranian fisheries & marine aquatics

Accurate scientific and practical plan for achieving the goals of the Islamic Republic of Iran within the framework of Vision development 1404, is the infrastructure achieving sustainable development of the country. Order to achieve the above mentioned objectives and in order to the comprehensive development plans in the country, Iranian fisheries research organization adjust the fifth developing plan for support of executive related departments in country with mobilization a large number researchers consists of several working groups of IFRO affiliated research centers. The fifth developing plan consist of three chapters for report of the forth developing plan and intrudction of research , construction plans and financial support (budjet) for period of 2011-2014 A.C