Global modeling of the effect of strong lateral viscosity variations on dynamic geoid and mantle flow velocities

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Gestational diabetes mellitus: risk factors development, occurrence, diagnostics and treatment (review)

Gestational diabetes is defined as a violation of carbohydrate metabolism resulting in hyperglycemia of varying severity, firstly revealed or developed during the pregnancy. The article presents current data on the occurrence, etiology and pathogenesis of gestational diabetes, as well as methods for screening and diagnostics of disorders of carbohydrate metabolism during pregnancy. It explains the basic principles of diet therap

Professional development of teachers in the conditions of a non-state educational institution

The article reveals the relevance of professional development of teachers of a non-governmental educational institution, due to the innovative nature of their activities and focus on revealing the potential of each child and the formation of his/her personality. The research problem has been initiated by increasing the role of professional communities as a form of advanced training for teachers and their opportunities for teachers of non-governmental educational institutions. The purpose of the study has been to justify theoretically, develop and test experimentally the effectiveness of a professional community model of teachers of a non-governmental educational institution as a self-learning organization. A number of theoretical and experimental methods have been used in the research, which included analysis of literature, modeling, design, data generalization, survey, observation, questionnaire, experiment, methods of mathematical and statistical data processing. In course of the research the following characteristics of activities of non-governmental educational institutions have been identified: a synergistic approach to administration; administration optimality; a non-governmental educational institution’s concept and development strategy and orientation to social needs. The main ideas for designing professional development of teachers of a non-governmental educational institution are as follows: interconnection of professional development with the concept of a non-governmental educational institution; consistency of professional development programs with the goals and values of school; orientation of professional development to improve the quality of education; providing professional development with evidence and examination of the effectiveness of educational activities; use of cooperation and expert task; duration of professional development programs and the priority of professional development in the activities of school management

The structure of flirtation as a speech genre in dialogues of Soviet intelligentsia: Composite genres and subgenres (based on plays by L. Zorin and V. Azernikov)

The article studies speech behavior of the class of Soviet intelligentsia in communicative situations of flirting. The research is based on Soviet comedy plays of the 1960s–1970s: “Dobryaki”, “Entsiklopedisty”, “Tranzit”, “Pokrovskie vorota”, “Teatral’naya fantaziya” by Leonid Zorin and “Vozmozhny varianty” by Valentin Azernikov. The relevance of the topic is related to the increased interest ofmodern linguistics in the verbal means typical of romantic discourse in general and of the genre of flirting in particular. Authors of dramatic texts create a speech portrait of the characters and place them in different communicative situations using speech genres and their verbal means of actualization, appropriated for the social group to which the character belongs. The semantic content of the lexeme “flirt” includes the following main features: ambiguity, elements of comic genres and play. The article presents the subgenres of the speech genre of flirting: compliment, gratitude, hint, joke. The author describes the revealed verbal means which actualize the speech genre of flirting in the speech of the class of Soviet intelligentsia. They are complicated and ambiguous constructions, polysemous words, lexical repetitions, use of plural “you”, vocabulary with positive semantics in assessing moral qualities, precedent statements. Stage directions describing characters’ intonation, gestures and movements are treated as supporting means of modeling of the non-verbal behavior in flirting. &nbsp

Sphingolipids in ischemic stroke

Determination of new biomarkers involved in the pathogenesis of ischemic stroke is an extremely important task from the point of view of identifying possible mechanisms for preventing the occurrence of an acute event, better diagnosis, and influencing the stages of pathogenesis to reduce the inflammatory focus. Sphingolipids belong to new biomarkers of atherosclerosis, which are involved in inflammation, apoptosis, and ischemia. The widespread introduction of mass spectrometry has made it possible to study sphingolipids in more detail. This review aims to summarize the available data on the role of sphingolipids in ischemic stroke

Lowinvasive technologies and hemostasis system at a hysteromyoma

Research objective. Study of condition of hemostasis system at patients with hysteromyoma complicated by bleeding; comparative estimation of hemostasis indicators at patients with uterine arteries embolization (the basic group n=48) and abdominal hysterectomy (comparison group n=65). Materials and methods. Complex study of the basic hemogram parameters and hemostasis at 162 patients with hysteromyoma and 30 patients without marked genital pathology (the II control group) was carried out. 48 patients formed the main group which was subjected to uterine arteries embolization for bleeding break; 65 patients (the comparative group) were surgically operated upon abdominal hysterectomy; 49 patients with hysteromyoma had no bleedings and formed the control group. Research of hemostasis system was carried out by means of test-tube method, and also by plotting set for express-diagnostics, analysis of thrombocyte unit of hemostasis system was realized with 2-channel analyzer of thrombocyte aggregation «Biola» — LA 230. Results. Presented analysis of hemostasiogram parameters allows to state development of chronic DIC-syndrome in women with hysteromyoma. Reliable shortening of coagulation index, decrease of thrombocyte aggregation function in comparison to the control group data were revealed. Conclusion. Development of hyper coagulation with increase of paracoagulative products with simultaneous activation of fibrinolysis processes in all the patients with hysteromyoma was revealed. Minimal effect of embolization of uterine arteries to hemostasis system in patients with hysteromyoma was marked. And they were intensified after surgical treatment, which is the evidence of definite advantages of this method unlike of hysterectom

Alterations in venous blood flow of lower uterus segment and cervix of uterus at physiological course of preliminary period

Research objective. The objective of this research is the study of venous blood flow parameters of lower uterus segment and cervix of uterus at the physiological course of preliminary period. Material and methods. The study was based on the investigation of the course of preliminary period of 90 patients with physiological delivery at term. Results. There is a growing rate of venous blood flow of lower uterus segment and cervix of uterus at rest as well as at peak of contractions. Conclusion. Veins are transformed into structures similar to lacunae at the physiological course of preliminary period. There is a growing rate of venous blood flow of lower uterus segment and cervix of uterus which results in blood storage and seems to be one of the mechanisms leading to cervical dilatation

Stages of logopedic rehabilitation of infants with congenital cleft lip and palate

В статье рассматриваются приемы работы логопеда с детьми раннего возраста с врожденной расщелиной губы и неба и раскрываются особенности применения логопедического воздействия в соответствии с этапами хирургического вмешательства.The article deals with the stages of logopedic work with infants with congenital cleft lip and palate, describes logopedic techniques and specificity of logopedic intervention in accordance with the stages of surgical treatment. The congenital cleft lip and palate in infants has the second or third highest incidence among all congenital developmental disorders. The modern medical technologies implemented in the state autonomous institution of healthcare of Sverdlovsk Region “Multi­profile Clinical Medical Center Bonum” in Ekaterinburg are aimed at early surgery of the primary defect in children with congenital cleft lip and palate - restoration of the structure of the speech apparatus. Surgery is performed in the period of pre-speech development

Sensitivity of the Antarctic ice sheets to the warming of marine isotope substage 11c

Funding: This research has been supported by the Swedish Research Council (grant no. 2016-04422), the German Research Foundation (grant no. 1158-365737614), the US National Science Foundation (grant no. PLR-1542930), and the Norwegian Polar Institute/NARE (grant no. 2015/38/7/NK/ihs). Jorge Bernales has been supported by the MAGIC-DML project through DFG SPP 1158 (RO 4262/1-6). The article processing charges for this open-access publication were covered by Stockholm University.Studying the response of the Antarctic ice sheets during periods when climate conditions were similar to the present can provide important insights into current observed changes and help identify natural drivers of ice sheet retreat. In this context, the marine isotope substage 11c (MIS11c) interglacial offers a suitable scenario, given that during its later portion orbital parameters were close to our current interglacial. Ice core data indicate that warmer-than-present temperatures lasted for longer than during other interglacials. However, the response of the Antarctic ice sheets and their contribution to sea level rise remain unclear. We explore the dynamics of the Antarctic ice sheets during this period using a numerical ice sheet model forced by MIS11c climate conditions derived from climate model outputs scaled by three glaciological and one sedimentary proxy records of ice volume. Our results indicate that the East and West Antarctic ice sheets contributed 4.0–8.2 m to the MIS11c sea level rise. In the case of a West Antarctic Ice Sheet collapse, which is the most probable scenario according to far-field sea level reconstructions, the range is reduced to 6.7–8.2 m independently of the choices of external sea level forcing and millennial-scale climate variability. Within this latter range, the main source of uncertainty arises from the sensitivity of the East Antarctic Ice Sheet to a choice of initial ice sheet configuration. We found that the warmer regional climate signal captured by Antarctic ice cores during peak MIS11c is crucial to reproduce the contribution expected from Antarctica during the recorded global sea level highstand. This climate signal translates to a modest threshold of 0.4 °C oceanic warming at intermediate depths, which leads to a collapse of the West Antarctic Ice Sheet if sustained for at least 4000 years.Publisher PDFPeer reviewe