74 research outputs found
A regenerative link in the ionic fluxes through the weaver potassium channel underlies the pathophysiology of the mutation
Neurobiology of rodent self-grooming and its value for translational neuroscience
Self-grooming is a complex innate behaviour with an evolutionarily conserved sequencing pattern and is one of the most frequently performed behavioural activities in rodents. In this Review, we discuss the neurobiology of rodent self-grooming, and we highlight studies of rodent models of neuropsychiatric disorders-including models of autism spectrum disorder and obsessive compulsive disorder-that have assessed self-grooming phenotypes. We suggest that rodent self-grooming may be a useful measure of repetitive behaviour in such models, and therefore of value to translational psychiatry. Assessment of rodent self-grooming may also be useful for understanding the neural circuits that are involved in complex sequential patterns of action.National Institutes of Health (U.S.) (Grant NS025529)National Institutes of Health (U.S.) (Grant HD028341)National Institutes of Health (U.S.) (Grant MH060379
Weaver mutation has differential effects on the dopamine- containing innervation of the limbic and nonlimbic striatum.
The content of amino acids in the developing cerebellar cortex and deep cerebellar nuclei of granule cell deficient mutant mice.
Concentrations of glutamic acid in cerebellar cortex and deep nuclei of normal mice and weaver, staggerer and nervous mutants.
Neurochemical and morphological consequences of axon terminal degeneration in cerebellar deep nuclei of mice with inherited purkinje cell degeneration.
Comparison of alterations in tyrosine hydroxylase, dopamine levels, and dopamine uptake in the striatum of the weaver mutant mouse
Expression of Zinc Finger Immediate Early Genes in Rat Brain After Permanent Middle Cerebral Artery Occlusion
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