Analysing privacy in visual lifelogging

The visual lifelogging activity enables a user, the lifelogger, to passively capture images from a first-person perspective and ultimately create a visual diary encoding every possible aspect of her life with unprecedented details. In recent years, it has gained popularities among different groups of users. However, the possibility of ubiquitous presence of lifelogging devices specifically in private spheres has raised serious concerns with respect to personal privacy. In this article, we have presented a thorough discussion of privacy with respect to visual lifelogging. We have re-adjusted the existing definition of lifelogging to reflect different aspects of privacy and introduced a first-ever privacy threat model identifying several threats with respect to visual lifelogging. We have also shown how the existing privacy guidelines and approaches are inadequate to mitigate the identified threats. Finally, we have outlined a set of requirements and guidelines that can be used to mitigate the identified threats while designing and developing a privacy-preserving framework for visual lifelogging

Congenital deficiency reveals critical role of ISG15 in skin homeostasis.

Ulcerating skin lesions are manifestations of human ISG15 deficiency, a type I interferonopathy. However, chronic inflammation may not be their exclusive cause. We describe two siblings with recurrent skin ulcers that healed with scar formation upon corticosteroid treatment. Both had a homozygous nonsense mutation in the ISG15 gene, leading to unstable ISG15 protein lacking the functional domain. We characterized ISG15-/- dermal fibroblasts, HaCaT keratinocytes, and human induced pluripotent stem cell-derived vascular endothelial cells. ISG15-deficient cells exhibited the expected hyperinflammatory phenotype, but also dysregulated expression of molecules critical for connective tissue and epidermis integrity, including reduced collagens and adhesion molecules, but increased matrix metalloproteases. ISG15-/- fibroblasts exhibited elevated ROS levels and reduced ROS scavenger expression. As opposed to hyperinflammation, defective collagen and integrin synthesis was not rescued by conjugation-deficient ISG15. Cell migration was retarded in ISG15-/- fibroblasts and HaCaT keratinocytes, but normalized under ruxolitinib treatment. Desmosome density was reduced in an ISG15-/- 3D epidermis model. Additionally, there were loose architecture and reduced collagen and desmoglein expression, which could be reversed by treatment with ruxolitinib/doxycycline/TGF-β1. These results reveal critical roles of ISG15 in maintaining cell migration and epidermis and connective tissue homeostasis, whereby the latter likely requires its conjugation to yet unidentified targets

Research data supporting: Iterative reactions of transient boronic acids enable sequential C-C bond formation

NMR filesThis record supports 'Iterative reactions of transient boronic acids enable sequential C-C bond formation', which has been published in Nature Chemistry.This work was supported by the EPSRC [grant numbers EP/K009494/1 and EP/M004120/1]