Self-similar decay of high Reynolds number Taylor-Couette turbulence

We study the decay of high-Reynolds number Taylor-Couette turbulence, i.e. the turbulent flow between two coaxial rotating cylinders. To do so, the rotation of the inner cylinder (Re$_i=2 \times 10^6$, the outer cylinder is at rest) is stopped within 12 s, thus fully removing the energy input to the system. Using a combination of laser Doppler anemometry and particle image velocimetry measurements, six decay decades of the kinetic energy could be captured. First, in the absence of cylinder rotation, the flow-velocity during the decay does not develop any height dependence in contrast to the well-known Taylor vortex state. Second, the radial profile of the azimuthal velocity is found to be self-similar. Nonetheless, the decay of this wall-bounded inhomogeneous turbulent flow does not follow a strict power law as for decaying turbulent homogeneous isotropic flows, but it is faster, due to the strong viscous drag applied by the bounding walls. We theoretically describe the decay in a quantitative way by taking the effects of additional friction at the walls into account.Comment: 7 pages, 6 figure

Azimuthal velocity profiles in Rayleigh-stable Taylor-Couette flow and implied axial angular momentum transport

We present azimuthal velocity profiles measured in a Taylor-Couette apparatus, which has been used as a model of stellar and planetary accretion disks. The apparatus has a cylinder radius ratio of $\eta = 0.716$, an aspect-ratio of $\Gamma = 11.74$, and the plates closing the cylinders in the axial direction are attached to the outer cylinder. We investigate angular momentum transport and Ekman pumping in the Rayleigh-stable regime. The regime is linearly stable and is characterized by radially increasing specific angular momentum. We present several Rayleigh-stable profiles for shear Reynolds numbers $Re_S \sim O(10^5) \,$, both for $\Omega_i > \Omega_o > 0$ (quasi-Keplerian regime) and $\Omega_o > \Omega_i > 0$ (sub-rotating regime) where $\Omega_{i,o}$ is the inner/outer cylinder rotation rate. None of the velocity profiles matches the non-vortical laminar Taylor-Couette profile. The deviation from that profile increased as solid-body rotation is approached at fixed $Re_S$. Flow super-rotation, an angular velocity greater than that of both cylinders, is observed in the sub-rotating regime. The velocity profiles give lower bounds for the torques required to rotate the inner cylinder that were larger than the torques for the case of laminar Taylor-Couette flow. The quasi-Keplerian profiles are composed of a well mixed inner region, having approximately constant angular momentum, connected to an outer region in solid-body rotation with the outer cylinder and attached axial boundaries. These regions suggest that the angular momentum is transported axially to the axial boundaries. Therefore, Taylor-Couette flow with closing plates attached to the outer cylinder is an imperfect model for accretion disk flows, especially with regard to their stability.Comment: 22 pages, 10 figures, 2 tables, under consideration for publication in Journal of Fluid Mechanics (JFM

Computational Screening of Tip and Stalk Cell Behavior Proposes a Role for Apelin Signaling in Sprout Progression

Angiogenesis involves the formation of new blood vessels by sprouting or splitting of existing blood vessels. During sprouting, a highly motile type of endothelial cell, called the tip cell, migrates from the blood vessels followed by stalk cells, an endothelial cell type that forms the body of the sprout. To get more insight into how tip cells contribute to angiogenesis, we extended an existing computational model of vascular network formation based on the cellular Potts model with tip and stalk differentiation, without making a priori assumptions about the differences between tip cells and stalk cells. To predict potential differences, we looked for parameter values that make tip cells (a) move to the sprout tip, and (b) change the morphology of the angiogenic networks. The screening predicted that if tip cells respond less effectively to an endothelial chemoattractant than stalk cells, they move to the tips of the sprouts, which impacts the morphology of the networks. A comparison of this model prediction with genes expressed differentially in tip and stalk cells revealed that the endothelial chemoattractant Apelin and its receptor APJ may match the model prediction. To test the model prediction we inhibited Apelin signaling in our model and in an \emph{in vitro} model of angiogenic sprouting, and found that in both cases inhibition of Apelin or of its receptor APJ reduces sprouting. Based on the prediction of the computational model, we propose that the differential expression of Apelin and APJ yields a "self-generated" gradient mechanisms that accelerates the extension of the sprout.Comment: 48 pages, 10 figures, 8 supplementary figures. Accepted for publication in PLoS ON

Mechanical cell-matrix feedback explains pairwise and collective endothelial cell behavior in vitro

In vitro cultures of endothelial cells are a widely used model system of the collective behavior of endothelial cells during vasculogenesis and angiogenesis. When seeded in an extracellular matrix, endothelial cells can form blood vessel-like structures, including vascular networks and sprouts. Endothelial morphogenesis depends on a large number of chemical and mechanical factors, including the compliancy of the extracellular matrix, the available growth factors, the adhesion of cells to the extracellular matrix, cell-cell signaling, etc. Although various computational models have been proposed to explain the role of each of these biochemical and biomechanical effects, the understanding of the mechanisms underlying in vitro angiogenesis is still incomplete. Most explanations focus on predicting the whole vascular network or sprout from the underlying cell behavior, and do not check if the same model also correctly captures the intermediate scale: the pairwise cell-cell interactions or single cell responses to ECM mechanics. Here we show, using a hybrid cellular Potts and finite element computational model, that a single set of biologically plausible rules describing (a) the contractile forces that endothelial cells exert on the ECM, (b) the resulting strains in the extracellular matrix, and (c) the cellular response to the strains, suffices for reproducing the behavior of individual endothelial cells and the interactions of endothelial cell pairs in compliant matrices. With the same set of rules, the model also reproduces network formation from scattered cells, and sprouting from endothelial spheroids. Combining the present mechanical model with aspects of previously proposed mechanical and chemical models may lead to a more complete understanding of in vitro angiogenesis.Comment: 25 pages, 6 figures, accepted for publication in PLoS Computational Biolog

Taylor-Couette turbulence at radius ratio η=0.5\eta=0.5: scaling, flow structures and plumes

Using high-resolution particle image velocimetry we measure velocity profiles, the wind Reynolds number and characteristics of turbulent plumes in Taylor-Couette flow for a radius ratio of 0.5 and Taylor number of up to $6.2\cdot10^9$. The extracted angular velocity profiles follow a log-law more closely than the azimuthal velocity profiles due to the strong curvature of this $\eta=0.5$ setup. The scaling of the wind Reynolds number with the Taylor number agrees with the theoretically predicted 3/7-scaling for the classical turbulent regime, which is much more pronounced than for the well-explored $\eta=0.71$ case, for which the ultimate regime sets in at much lower Ta. By measuring at varying axial positions, roll structures are found for counter-rotation while no clear coherent structures are seen for pure inner cylinder rotation. In addition, turbulent plumes coming from the inner and outer cylinder are investigated. For pure inner cylinder rotation, the plumes in the radial velocity move away from the inner cylinder, while the plumes in the azimuthal velocity mainly move away from the outer cylinder. For counter-rotation, the mean radial flow in the roll structures strongly affects the direction and intensity of the turbulent plumes. Furthermore, it is experimentally confirmed that in regions where plumes are emitted, boundary layer profiles with a logarithmic signature are created

Exploring the phase space of multiple states in highly turbulent Taylor-Couette flow

We investigate the existence of multiple turbulent states in highly turbulent Taylor-Couette flow in the range of $\mathrm{Ta}=10^{11}$ to $9\cdot10^{12}$, by measuring the global torques and the local velocities while probing the phase space spanned by the rotation rates of the inner and outer cylinder. The multiple states are found to be very robust and are expected to persist beyond $\mathrm{Ta}=10^{13}$. The rotation ratio is the parameter that most strongly controls the transitions between the flow states; the transitional values only weakly depend on the Taylor number. However, complex paths in the phase space are necessary to unlock the full region of multiple states. Lastly, by mapping the flow structures for various rotation ratios in a Taylor-Couette setup with an equal radius ratio but a larger aspect ratio than before, multiple states were again observed. Here, they are characterized by even richer roll structure phenomena, including, for the first time observed in highly turbulent TC flow, an antisymmetrical roll state.Comment: 9 pages, 7 figure