Malignant Melanoma of the Penis in a Patient with a History of Prostate Brachytherapy: A Case Report and Review of Literature

Introduction: Penile melanoma is rare and usually results in a poor prognosis. We report a case on a male who presents with penile melanoma after being treated with radiation therapy for his prostate cancer.Presentation of Case: We describe a rare case of penile melanoma discovered  3 years post radiation therapy for prostate cancer in an 84 year old gentleman. The patient presented with a dark skin lesion on the glans. It was noted in the patient’s chart that there was no prior history of melanoma or sun exposure to the genital region. Upon further work up, the patient was found to have penile melanoma without metastases. The patient opted for a partial penectomy. After routine follow up, through 7 year later, the patient continues to show no evidence of reoccurrence of melanoma or metastatic disease.Conclusion: While melanoma is common in the male gender, penile melanoma is found to be only a very small percentage of these cases. Particular interest was taken in this case due to the patient’s history of being treated with Brachytherapy I-125 seeds for his prostate cancer. Although probable cause of the melanoma is unclear, further investigation is warranted for patients who develop penile melanoma post radiation therapy for prostate cancer.

Euthanasie und Menschenversuche im Dritten Reich, mit einer ethischen Analyse der Menschenversuche

The idea in Nazi-Germany of a “pure” Germany culminated in the systematic murder of millions of people, and within that, the crimes against humanity of euthanasia and human experimentation. The memories of child and adult euthanasia pervade society even today. This project looks at the development of Nazi-euthanasia and the memoirs and films about it, which leave lasting impressions by engraining in audience member’s minds the real facts about euthanasia and euthanasia institutions. The victims of euthanasia were often used in Nazi human experimentation, a product of the Nazi pursuit of scientific advancement. This project also examines these human experiments, which left the victims mutilated or dead, without producing much viable data, and the accounts about human experimentation. These accounts invite audiences to question the purpose of the experimentation and the very definition of humanity, in light of the myriad of suffering caused by many experiments with no reasonable chance of success. Therefore, these human experiments and the experimenters were judged upon biomedical ethical standards to determine if the experiments or experimenters were in any respect ethical, and whether or not it would be permissible to use any legitimate results from the experiments. After careful, close analysis with Tom Beauchamp and James Childress’ biomedical ethical principles, the experiments, experimenters, and results are by all measures unethical as they stand