Minimal kernels of Dirac operators along maps

Let $M$ be a closed spin manifold and let $N$ be a closed manifold. For maps $f\colon M\to N$ and Riemannian metrics $g$ on $M$ and $h$ on $N$, we consider the Dirac operator $D^f_{g,h}$ of the twisted Dirac bundle $\Sigma M\otimes_{\mathbb{R}} f^*TN$. To this Dirac operator one can associate an index in $KO^{-dim(M)}(pt)$. If $M$ is $2$-dimensional, one gets a lower bound for the dimension of the kernel of $D^f_{g,h}$ out of this index. We investigate the question whether this lower bound is obtained for generic tupels $(f,g,h)$

Flourishing ‘older-old’ (80+) adults: personal projects and their enabling places

This paper sets out a framework for exploring flourishing in older age through the lens of what older adults are doing in their lives. Applying a model from positive psychology called personal project analysis (PPA) our study captures a snapshot of older people's goals and their environmental context. Targeting older people aged 80+ we applied PPA methods in a semi-structured interview to elicit participants’ personal projects which were scored on eight wellbeing dimensions (e.g., fun, stress). Qualitative data analysis identified what types of personal projects are employed by this older demographic and the environments in which they are carried out. Results showed our participants were vitally engaged in a wide spectrum of projects exercised in a range of ‘enabling places’ which we categorised as (1) restorative niches (places that afford psychological restoration) such as nature settings (e.g. a garden, local park or riverside); (2) affinity niches (places that afford social opportunities) such as religious venues, social clubs, or cafés; and (3) flow niches (places that afford immersion in mental or physical tasks) such as the home (e.g. the kitchen) or a place associated with a previous career or amateur sport (e.g. cricket club). Our findings are discussed in relation to older people's wellbeing and the role of the built environment. Despite the increasingly negative stereotyping of the ‘older-old’ our study shows that the final decades of life can be a period of continuing growth and learning, a life stage with its own distinct character, rather than a period of decline

Vortex information display system program description manual

A vortex information display system is described which provides flexible control through system-user interaction for collecting wing-tip-trailing vortex data, processing this data in real time, displaying the processed data, storing raw data on magnetic tape, and post processing raw data. The data is received from two asynchronous laser Doppler velocimeters (LDV's) and includes position, velocity, and intensity information. The raw data is written onto magnetic tape for permanent storage and is also processed in real time to locate vortices and plot their positions as a function of time. The interactive capability enables the user to make real time adjustments in processing data and provides a better definition of vortex behavior. Displaying the vortex information in real time produces a feedback capability to the LDV system operator allowing adjustments to be made in the collection of raw data. Both raw data and processing can be continually upgraded during flyby testing to improve vortex behavior studies. The post-analysis capability permits the analyst to perform in-depth studies of test data and to modify vortex behavior models to improve transport predictions

Including Systematic Uncertainties in Confidence Interval Construction for Poisson Statistics

One way to incorporate systematic uncertainties into the calculation of confidence intervals is by integrating over probability density functions parametrizing the uncertainties. In this note we present a development of this method which takes into account uncertainties in the prediction of background processes, uncertainties in the signal detection efficiency and background efficiency and allows for a correlation between the signal and background detection efficiencies. We implement this method with the Feldman & Cousins unified approach with and without conditioning. We present studies of coverage for the Feldman & Cousins and Neyman ordering schemes. In particular, we present two different types of coverage tests for the case where systematic uncertainties are included. To illustrate the method we show the relative effect of including systematic uncertainties the case of dark matter search as performed by modern neutrino tel escopes.Comment: 23 pages, 10 figures, replaced to match published versio

Quantum oscillations of self-dual Abrikosov-Nielsen-Olesen vortices

The mass shift induced by one-loop quantum fluctuations on self-dual ANO vortices is computed using heat kernel/generalized zeta function regularization methods. The quantum masses of super-imposed multi-vortices with vorticity lower than five are given. The case of two separate vortices with a quantum of magnetic flux is also discussed.Comment: RevTex, 13 pages, 4 figures, 7 tables. Minor corrections. Version to appear in Physical Review

How effective is the Forestry Commission Scotland's woodland improvement programme--'Woods In and Around Towns' (WIAT)--at improving psychological well-being in deprived urban communities? A quasi-experimental study

Introduction: There is a growing body of evidence that suggests that green spaces may positively influence psychological well-being. This project is designed to take advantage of a natural experiment where planned physical and social interventions to enhance access to natural environments in deprived communities provide an opportunity to prospectively assess impacts on perceived stress and mental well-being.<p></p> Study design and methods: A controlled, prospective study comprising a repeat cross-sectional survey of residents living within 1.5 km of intervention and comparison sites. Three waves of data will be collected: prephysical environment intervention (2013); postphysical environment intervention (2014) and postwoodland promotion social intervention (2015). The primary outcome will be a measure of perceived stress (Perceived Stress Scale) preintervention and postintervention. Secondary, self-report outcomes include: mental well-being (Short Warwick-Edinburgh Mental Well-being Scale), changes in physical activity (IPAQ-short form), health (EuroQoL EQ-5D), perception and use of the woodlands, connectedness to nature (Inclusion of Nature in Self Scale), social cohesion and social capital. An environmental audit will complement the study by evaluating the physical changes in the environment over time and recording any other contextual changes over time. A process evaluation will assess the implementation of the programme. A health economics analysis will assess the cost consequences of each stage of the intervention in relation to the primary and secondary outcomes of the study.<p></p> Ethics and dissemination: Ethical approval has been given by the University of Edinburgh, Edinburgh College of Art Research, Ethics and Knowledge Exchange Committee (ref. 19/06/2012). Findings will be disseminated through peer-reviewed publications, national and international conferences and, at the final stage of the project, through a workshop for those interested in implementing environmental interventions.<p></p&gt

Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2.

Poly(ADP-ribose) polymerase-1 (PARP-1) has become an important pharmacological target in the treatment of cancer due to its cellular role as a 'DNA-strand break sensor', which leads in part to resistance to some existing chemo- and radiological treatments. Inhibitors have now been developed which prevent PARP-1 from synthesizing poly(ADP-ribose) in response to DNA-breaks and potentiate the cytotoxicity of DNA damaging agents. However, with the recent discoveries of PARP-2, which has a similar DNA-damage dependent catalytic activity, and additional members containing the 'PARP catalytic' signature, the isoform selectivity and resultant pharmacological effects of existing inhibitors are brought into question. We present here the crystal structure of the catalytic fragment of murine PARP-2, at 2.8 A resolution, and compare this to the catalytic fragment of PARP-1, with an emphasis on providing a possible framework for rational drug design in order to develop future isoform-specific inhibitors