Flow Synthesis of Ethyl Isocyanoacetate Enabling the Telescoped Synthesis of 1,2,4-Triazoles and Pyrrolo-[1,2-c]pyrimidines

The efficient flow synthesis of important heterocyclic building blocks based on the 1,2,4-triazole and pyrrolo[1,2-c]pyrimidine scaffold has been achieved. Crucially, a telescoped continuous flow process was developed based on the reaction of N-formylglycine with triphosgene to deliver a stream of ethyl isocyanoacetate in situ, which subsequently yielded the desired heterocyclic entities in a telescoped reaction. Additionally, the functionalisation of the pyrrolo[1,2-c]pyrimidine core via subsequent SEAr reactions was studied revealing insight into a ‘halogen dance’ phenomenon associated with these medicinally relevant architectures

Non-Finite Dimensional Closed Vector Spaces of Universal Functions for Composition Operators

AbstractLet H(Ω) be the space of analytic functions on a complex region Ω, which is not the punctured plane. In this paper, we prove that if a sequence of automorphisms {φn}n ≥ 0 of Ω has the property that for every compact subset K ⊂ Ω there is a positive integer n such that K ∩ φn(K) = 0, then there exists an infinite dimensional closed vector subspace F ⊂ H(Ω) such that for all f ∈ F\{0} the orbit (f ∘ φn)n ≥ 0 is dense in H(Ω). The corresponding result for the punctured plane is somewhat different and is also studied

Quantum fluctuations of classical skyrmions in quantum Hall Ferromagnets

In this article, we discuss the effect of the zero point quantum fluctuations to improve the results of the minimal field theory which has been applied to study %SMG the skyrmions in the quantum Hall systems. Our calculation which is based on the semiclassical treatment of the quantum fluctuations, shows that the one-loop quantum correction provides more accurate results for the minimal field theory.Comment: A few errors are corrected. Accepted for publication in Rapid Communication, Phys. Rev.

Agroecological practices to support tropical livestock farming systems: a Caribbean and Latin American perspective

With global climate changes currently occurring, and particularly given the severe energy and food shortages occurring throughout tropical regions, agroecological (AE) systems are drawing renewed attention as an efficient alternative to intensive models of production, particularly unsuitable in regions of the world such as the Caribbean or Latin America. There is a pressing need to focus on livestock farming systems (LFS) and characterize their potential contributions to global sustainability. A multidisciplinary approach is needed to address these multiple and complex problems. Traditionally, LFS have shown their sustainability high potential. The purpose of this work is to highlight solutions to minimize inputs, by describing some success and diverse case studies through the Caribbean. These systems were analyzed at different levels: animal/function, farm/family, and territory/society. This produced a set of guidelines that help to increase the efficiency of tropical systems, particularly those concerned with (1) choosing the best-suited genotypes, while enhancing population biodiversity; (2) matching the farming system to the available resources, feed, and by-products; (3) steering the whole farming system through reproduction management with no hormonal treatment, while facilitating system reproducibility and increasing performances; (4) controlling health constraints instead of annihilating risks and implement an integrated management design to reduce chemical treatments or increase the use of nutraceuticals; and (5) mitigating climate constraints by using soft techniques. In the second part of this work, some integrated systems are described. The Tosoly farm of Colombia, for instance, is conceived as a totally integrated crop-livestock system, allowing the additional production of energy at the farm level. Thus, it epitomizes the positive impact that livestock can exert upon the environment. The case study of Haiti indicates how AE practices can help in designing a pro-poor sustainable milk production system. It concerns an entire dairy sector built all over the country on the basis of micro-units of milk production and processinginfo:eu-repo/semantics/acceptedVersio

Perioperative management in thoracic surgery.

Thoracic surgery has undergone significant advances in recent years related to anesthetic and surgical techniques and the prevention and management of complications related to the procedure. This has allowed improvements in patient clinical outcomes in surgeries of this kind. Despite the above, thoracic surgery, especially related to pulmonary resection, is not without risk, and is associated to considerable morbidity and mortality. Fast track or enhanced recovery after anesthesia protocols, minimally invasive surgery, and intraoperative anesthetic management improve the prognosis and safety of thoracic surgery. Patients in the postoperative period of major thoracic surgery require intensive surveillance, especially the first 24–72h after surgery. Admission to the ICU is especially recommended in those patients with comorbidities, a reduced cardiopulmonary reserve, extensive lung resections, and those requiring support due to life-threatening organ failure. During the postoperative period, intensive cardiorespiratory monitoring, proper management of thoracic drainage, aggressive pain control (multimodal analgesia and regional anesthetic techniques), nausea and multimodal rehabilitation are key elements for avoiding adverse events. Medical complications include respiratory failure, arrhythmias, respiratory infections, atelectasis and thromboembolic lung disease. The most frequent surgical complications are hemothorax, chylothorax, bronchopleural fistula and prolonged air leakage. The multidisciplinary management of these patients throughout the perioperative period is essential in order to ensure the best surgical outcomes.post-print512 K

Selberg Supertrace Formula for Super Riemann Surfaces III: Bordered Super Riemann Surfaces

This paper is the third in a sequel to develop a super-analogue of the classical Selberg trace formula, the Selberg supertrace formula. It deals with bordered super Riemann surfaces. The theory of bordered super Riemann surfaces is outlined, and the corresponding Selberg supertrace formula is developed. The analytic properties of the Selberg super zeta-functions on bordered super Riemann surfaces are discussed, and super-determinants of Dirac-Laplace operators on bordered super Riemann surfaces are calculated in terms of Selberg super zeta-functions.Comment: 43 pages, amste

Tracing the sources, fate, and recycling of fine sediments across a river-delta interface

Deltaic floodplains are thought to be long-term depositional environments, however there remains a limited understanding regarding timescales of depositional and erosional events, sediment delivery pathways and sediment storage. This study uses sediment concentration and sediment fingerprinting to examine the contribution of surface and subsurface sources to suspended sediment transiting the Lower Roanoke River, North Carolina, United States. The Lower Roanoke is disconnected from its high-gradient uplands in the Piedmont and Appalachian Mountains by a series of dams, which effectively restricts suspended sediment delivery from the headwaters. Accordingly, sediments from the Lower Roanoke River basin are the primary source of suspended sediment downstream of the dams. The fingerprinting method utilized fallout radionuclide tracers (210Pbxs and 137Cs) to examine the spatial variation of sediment-source contributions to suspended-sediment samples (n = 79). Three end-member sources were sampled: 1. surface sources (floodplains and topsoils; n = 60), 2. subsurface sources (channel bed and banks; n = 66), and 3. deltaic sources (delta front and prodelta; n = 11). The results demonstrate that with decreasing river slope and increasing influence of estuarine-driven flow dynamics, the relative contribution of surface sediments to the suspended-sediment load increases from 20% (± 2%) in the upper reach, to 67% (± 1%) in the Roanoke bayhead delta (BHD). At the river mouth, the surface-sediment contribution decreases, and the delta front and prodelta sediments contribute 74% (± 1%) to the suspended load. These results indicate, that during the delta transgression, erosion of the lower delta provides an additional source of sediment to the upper delta. At the same time, the lower deltaic plain, considered a sediment sink and long-term sediment-storage site, becomes erosional. The lower river and distributary network of the delta plain, which were thought to only disperse sediments in a seaward direction, may also have an important landward-directed sediment-dispersal component that provides nourishment and fortification to the upper BHD, at the cost of the eroding lower delta. Recognition of these contrasting sediment pathways in the Roanoke River highlights that these complex bidirectional processes may exist in other eroding deltas. Understanding these bidirectional processes will be necessary for the ongoing management of deltaic environments under increasing anthropogenic stress such as land use change and accelerating sea-level rise

Quantized Skyrmion Fields in 2+1 Dimensions

A fully quantized field theory is developped for the skyrmion topological excitations of the O(3) symmetric CP$^1$-Nonlinear Sigma Model in 2+1D. The method allows for the obtainment of arbitrary correlation functions of quantum skyrmion fields. The two-point function is evaluated in three different situations: a) the pure theory; b) the case when it is coupled to fermions which are otherwise non-interacting and c) the case when an electromagnetic interaction among the fermions is introduced. The quantum skyrmion mass is explicitly obtained in each case from the large distance behavior of the two-point function and the skyrmion statistics is inferred from an analysis of the phase of this function. The ratio between the quantum and classical skyrmion masses is obtained, confirming the tendency, observed in semiclassical calculations, that quantum effects will decrease the skyrmion mass. A brief discussion of asymptotic skyrmion states, based on the short distance behavior of the two-point function, is also presented.Comment: Accepted for Physical Review

Milho como forragem hidropónica alternativa

A produção de forragem hidropónica (FH) permite obter matéria verde utilizando sementes de leguminosas e/ou de gramíneas que são colocadas em tabuleiros em condições favoráveis de germinação durante um curto período de tempo. Em Portugal, é utilizada a cevada grão para produção de FH para ruminantes. Com este ensaio, pretendeu-se comparar a produção de biomassa e a composição química de FH obtidas a partir da germinação de sementes de cevada [CV], de milho biológico [MB] e de milho híbrido [MH]).Trabalho financiado por fundos nacionais através da FCT – Fundação para a Ciência e a Tecnologia, I.P., no âmbito do projeto UIDB/00681/2020.info:eu-repo/semantics/publishedVersio