Caracterización sociodemográfica de la satisfacción laboral en personal hospitalario

Objective: the purpose was to determine the association of job satisfaction with the sociodemographic variables of the captive population. Materials and methods: it was a transversal and analytical design with a sample of 526 workers, to whom a questionnaire of sociodemographic and labor data was applied, and the Questionnaire of Job Satisfaction S21/ 26. It presents six factors that allow to evaluate Satisfaction with Oversight and Participation in the Organization (I), with Remuneration and Benefits (II), Intrinsic Satisfaction (III), with the Physical Environment (IV), with Quantity of Production (V) and with Quality of Production (VI). Results: age was found to be associated with dimensions I and II with p= 0,037 and p= 0,038 respectively. The variable of schooling was associated with dimensions IV (p= 0,008), V (p= 0,000) and VI (p= 0,059). The labour category variable had a value of p= 0.010, p= 0.000 and p= 0.001 for dimensions IV, V and VI, respectively. Finally, the variable working seniority was associated with dimension I (p=0.057). Conclusions: It is concluded that the institution studied generally offers its workers the means that satisfy their professional expectations, but emphasis should be placed on improving the dimensions in which dissatisfaction is generated in order to forge an environment conducive to the labour development of the workers and thus contribute to improving their quality of life.Objetivo: El propósito de este artículo fue determinar la asociación de la satisfacción laboral con las variables sociodemográficas de trabajadores hospitalarios. Materiales y métodos : con diseño transversal y analítico en una muestra probabilística de 526 trabajadores, se aplicó un cuestionario de datos sociodemográficos y laborales, y el Cuestionario de Satisfacción Laboral S21 / 26 que consta de seis dimensiones que permiten evaluar la Satisfacción con la Supervisión y Participación en la Organización (I), con la Remuneración y las Prestaciones (II), Satisfacción Intrínseca (III), con el Ambiente Físico (IV), con la Cantidad de Producción (V), y con la Calidad de Producción (VI). Resultados: se determinó que la edad se asoció con las dimensiones I y II con p = 0,037 yp = 0,038 respectivamente. La variable escolaridad se asoció con las dimensiones IV (p = 0,008), V (p = 0,000) y VI (p = 0,059). La variable de categoría laboral tuvo un valor de p = 0.010, p = 0.000 yp = 0.001 para las dimensiones IV, V y VI, respectivamente. Finalmente, la variable antigüedad laboral, se asoció con la dimensión I (p = 0.057). Conclusiones: se concluye que la institución estudiada en general ofrece a sus trabajadores los medios que satisfacen sus expectativas profesionales, pero se debe hacer énfasis en mejorar las dimensiones en las que se genera el descontento para forjar un ambiente propicio al desarrollo laboral de los trabajadores y así contribuir para mejorar su calidad de vida

Estudio transversal para comparar el rendimiento académico en estudiantes mexicanos de educación secundaria en función de su índice de masa corporal

Introduction: Mexico ranks second in the world in childhood obesity. The impact of obesity on comprehensive health is evident; however, the evidence of its influence on academic performance in Mexican adolescents is still scarce. Objective: to compare the academic performance of high school students based on their Body Mass Index (BMI). Material and methods: cross-sectional study in a probabilistic sample of 156 students. Weight and height were taken and BMI was classified according to the criteria of the World Health Organization (WHO). The average grade was used to measure academic performance. Descriptive statistics and Chi square were applied to compare groups. Results: 50% women; the mean age was 13.1 years (DT = .94). 32.7% were obese, 19.2% overweight and 48.1 % normal weight. The mean score was 8.6 (DT = .82), 42.3% had a high performance, 38.5% an average performance and 19.2% a low performance. High performance was more frequent in the obesity group (40.9%), followed by normal weight (36.4%) and overweight (22.7%). When comparing the academic performance in the groups by BMI, statistical differences were found (p = 0.01). Conclusions: the prevalence of overweight and obesity is higher than the national average. There are differences in academic performance. Adolescents with obesity had a higher school performance.Introducción: México ocupa el segundo lugar del mundo en obesidad infantil. El impacto de la obesidad sobre la salud integral es evidente; sin embargo, la evidencia de su influencia sobre el rendimiento académico en adolescentes mexicanos es todavía escasa. Objetivo: comparar el rendimiento académico de estudiantes de secundaria en función de su Índice de Masa Corporal (IMC). Material y métodos: estudio transversal en muestra probabilística de 156 estudiantes. Se tomó peso y talla y se clasificó el IMC según los criterios de la Organización Mundial de la Salud (OMS). Para medir el rendimiento académico se utilizó la calificación promedio. Se aplicó estadística descriptiva y Chi cuadrado para comparar grupos. Resultados: 50% mujeres; la media de edad fue de 13,1 años (desviación típica [DT]= 0,94). El 32,7 % presentaron obesidad, 19,2 % sobrepeso y el 48,1 % peso normal. La media de calificación fue 8,6 (DT= 0,82), el 42,3% tenía un rendimiento académico alto, el 38,5% un rendimiento medio y el 19,2% un rendimiento bajo. El rendimiento alto fue más frecuente en el grupo de obesidad (40,9%), seguido de peso normal (36,4%) y sobrepeso (22,7%). Al comparar el rendimiento académico en los grupos por IMC, se encontraron diferencias estadísticas (p=0,01). Conclusiones: la prevalencia de sobrepeso y obesidad es más alta que la media nacional. Existen diferencias en el rendimiento académico en función del IMC. Los adolescentes con obesidad presentaron un rendimiento escolar más alto

Alienação parental como violação dos direitos humanos da criança a partir da psicologia do desenvolvimento: Alinhamento parental e desenvolvimento infantil como um direito humano

Parental alienation syndrome has been identified more markedly, since the psychiatrist Richard Gardner (1985), defined it as "a childhood disorder, derived from conflicts between parents, related to the custody of their daughters and sons, the result of a programming induced to girls and boys by the defamation of the alienating parent towards the other”. It can be identified as the rejection of the daughter or son, towards their father or mother, as a form of punishment and revenge exercised by one of those parents against their counterpart, who is generally the one who does not maintain custody and custody; This can be a form of child abuse and therefore violate the human rights of children. Objective: To reflect on parental alienation as a violation of children's human rights from developmental psychology. Results: This phenomenon is contemplated in the Constitutional text of the Convention on the Rights of the Child and the diverse Mexican legislation, particularly what is indicated by the General Law on the Rights of Girls, Boys and Adolescents in its article 23, which protects the right that they have, despite the fact that their families are separated, even due to divorce, to live together and maintain personal relationships and direct contact with their mother and father and their other family, doing it regularly, which is in accordance with with their right to mental development and well-being, despite this, it does not appear in the DSM-5. Conclusion: This syndrome violates human rights, since the exercise of rights in childhood must be guaranteed, an affective, understanding and non-violent environment, taking care of their psychological integrity, eliminating acts that impair their integral development, violate respect, generate violence or rejection of their relationships with their parents and other relatives.El síndrome de alienación parental ha venido identificándose más marcadamente, desde que el psiquiatra Richard Gardner (1985), lo definió como “un trastorno de la infancia, derivado de conflictos entre los progenitores, relativo a la custodia de sus hijas e hijos, resultado de una programación inducida a las niñas y los niños por la difamación del progenitor alienador hacia el otro”. Puede identificarse como el rechazo de la hija o hijo, hacia su padre o madre, como una forma de castigo y venganza ejercida por uno de esos progenitores en contra de su contraparte, que generalmente es quien no mantiene la guarda y custodia; esto puede ser una forma de maltrato infantil y por ende atacar contra los derechos humanos de la niñez. Objetivo : Reflexionar acerca dealienación parental como violación de derechos humanos de la niñez desde la psicología del desarrollo. Results : Este fenómeno, se contempla en el texto Constitucional de la Convención sobre los Derechos del Niño y la diversa legislación mexicana, particularmente lo señalado por la Ley General de los Derechos de Niñas, Niños y Adolescentes en su artículo 23, que ampara el derecho que tienen estos, a pesar de que sus familias se encuentran separadas, inclusive por motivo de divorcio, a convivir y mantener relaciones personales y contacto directo con su madre y padre y los demás familia de ellos, realizándolo de modo regular, lo que va acorde con su derecho a un desarrollo y bienestar mental, pese a ello, no aparece en el DSM-5. Conclusión:Este síndrome, violenta derechos humanos, pues se debe garantizar el ejercicio de derechos en la infancia, un entorno afectivo, comprensivo y sin violencia, cuidando su integridad psicológica, eliminando actos que menoscaben su desarrollo integral, vulneren el respeto, generen violencia o rechazo de sus relaciones con sus padres y otros familiares.A síndrome da alienação parental tem sido identificada de forma mais acentuada, desde que o psiquiatra Richard Gardner (1985), a definiu como “um distúrbio da infância, derivado de conflitos entre pais, relacionados à guarda de suas filhas e filhos, resultado de uma programação induzida às meninas e meninos pela difamação do genitor alienador para com o outro”. Pode ser identificada como a rejeição da filha ou do filho, em relação ao pai ou à mãe, como forma de punição e vingança exercida por um desses pais contra o seu homólogo, que geralmente é aquele que não mantém guarda e guarda; Isso pode ser uma forma de abuso infantil e, portanto, violar os direitos humanos das crianças. Objetivo: Refletir sobre a alienação parental como violação dos direitos humanos da criança a partir da psicologia do desenvolvimento. Resultados: Este fenômeno está contemplado no texto constitucional da Convenção sobre os Direitos da Criança e nas diversas legislações mexicanas, particularmente o que indica a Lei Geral dos Direitos de Meninas, Meninos e Adolescentes em seu artigo 23, que protege a direito que têm, apesar de as suas famílias estarem separadas, mesmo por motivo de divórcio, de viverem juntas e manterem relações pessoais e contactos directos com a mãe e o pai e com os restantes familiares, fazendo-o regularmente, o que está de acordo com os seus direito ao desenvolvimento mental e ao bem-estar, apesar disso, não consta no DSM-5. Conclusão: Esta síndrome viola os direitos humanos, uma vez que deve ser garantido o exercício dos direitos na infância, um ambiente afetivo, compreensivo e não violento, cuidando de sua integridade psicológica, eliminando atos que prejudiquem seu desenvolvimento integral, violem o respeito, gerem violência ou rejeição de seus relacionamentos com seus pais e outros parentes

Experiências de trabalhadoras domésticas sobre suas condições de trabalho ligadas à sua saúde

According to the ILO (2011), Domestic Workers are a considerable workforce in the informal sector and are among the most vulnerable workers. The above is relevant when considering that 93% of this population are women, and it is one of the work contexts with the most disadvantages (Lexartza et al., 2016; Velázquez et al., 2020). Objective: Describe the experiences of their working conditions linked to health from the perspective of domestic workers. Method: Qualitative, phenomenological design. With a purposeful sample, semi-structured interviews were applied to six domestic workers using the snowball technique for the sample, establishing the data saturation criterion to determine the sample size, the inclusion criterion was that they were employed at the time of the interview, over 18 years of age and will agree to participate voluntarily. Categories of analysis were carried out through vertical and horizontal reading, segmenting and reducing the data. The categories were validated by two expert readers. Results: None of the participants have a work contract, they do not have access to social security, half of them have had a bonus at some point and only one has had it every year. The domestic worker participants report that they are unaware of the rights that the Federal Labor Law grants them, they assume that the legal benefits are considerations of the employers because they are good employers. They do not refer to physical, chemical, ergonomic, biological or psychosocial risks, although they do recognize work overload and some musculoskeletal discomfort, fatigue and injuries derived from their work. Conclusions: Domestic employees refer among their experiences to the absence of contracts in their labor relationships, which is why they consider that these relationships are informal since in their speeches there are expressions such as the lady who helped you and not in labor terms. Legal benefits such as vacations and rest days are granted to workers, depending on the needs of the employer without prior notice, that is, if the employer has to leave due to an emergency or vacation, then he decides that those days are when household workers will be laid off. When access to social security, overtime or bonuses are granted by the employer, it is considered an act of good will or a trait of benevolence and not as an employer obligation.De acuerdo con la OIT (2011), las Personas Trabajadoras del Hogar son una fuerza considerable de trabajo en el sector informal y se ubican entre los trabajadores más vulnerados. Lo anterior resulta relevante al considerar que el 93% de esta población son mujeres, y es uno de los contextos laborales con más desventajas (Lexartza et al., 2016; Velázquez et al., 2020). Objetivo: Describir las experiencias de sus condiciones laborales vinculadas con la salud desde la perspectiva de trabajadoras del hogar. Método: Diseño cualitativo, fenomenológico. Con muestra propositiva, se aplicaron entrevistas semiestructuradas a seis trabajadoras del hogar utilizando la técnica de bola de nieve para la muestra, estableciendo el criterio de saturación de datos para determinar el tamaño muestral, el criterio de inclusión fue que estuvieran empleadas en el momento de la entrevista, mayores de 18 años y aceptaran participar voluntariamente. Se realizaron categorías de análisis por medio de la lectura vertical y horizontal, segmentando y reduciendo los datos. Las categorías se validaron por dos lectores expertos. Resultados: Ninguna participante cuentan con un contrato de trabajo, no tienen acceso a la seguridad social, la mitad de ellas ha tenido alguna vez aguinaldo y solo una lo ha tenido todos los años. Las participantes trabajadoras del hogar refieren que desconocen los derechos que la Ley Federal del Trabajo les otorga, suponen que las prestaciones de ley son consideraciones de los empleadores porque son buenos patrones. No refieren los riesgos físicos, químicos, ergonómicos, biológicos o psicosociales, aunque sí reconocen la sobrecarga de trabajo y algunas molestias músculo esqueléticas, fatiga y lesiones, derivadas de su trabajo. Conclusiones: Las empleadas del hogar refieren entre sus experiencias la ausencia de contratos en sus relaciones laborales, por lo que consideran que dichas relaciones son informales ya que en sus discursos se encuentran expresiones como a la señora que le ayudo y no en términos laborales. Prestaciones de Ley como vacaciones y días de descanso, se conceden a las trabajadoras, en función de las necesidades del empleador sin previo aviso, es decir, si la persona empleadora tiene que salir por una emergencia o por vacaciones entonces decide que esos días son cuando descasará el personal de trabajo del hogar. Cuando el acceso a la seguridad social, horas extras o aguinaldo son otorgadas por la persona empleadora se considera como un acto de buena voluntad o un rasgo de benevolencia y no como una obligación patronal.De acordo com a OIT (2011), os Trabalhadores Domésticos constituem uma força de trabalho considerável no setor informal e estão entre os trabalhadores mais vulneráveis. O acima exposto é relevante quando se considera que 93% desta população são mulheres, e é um dos contextos de trabalho com mais desvantagens (Lexartza et al., 2016; Velázquez et al., 2020). Objetivo: Descrever as vivências de suas condições de trabalho vinculadas à saúde na perspectiva das trabalhadoras domésticas. Método: Desenho qualitativo e fenomenológico. Com amostra proposital, foram aplicadas entrevistas semiestruturadas com seis trabalhadoras domésticas utilizando a técnica bola de neve para a amostra, estabelecendo o critério de saturação de dados para determinar o tamanho da amostra, o critério de inclusão foi que estivessem empregadas no momento da entrevista, acima de 18 anos de idade e concordará em participar voluntariamente. As categorias de análise foram realizadas por meio de leitura vertical e horizontal, segmentação e redução dos dados. As categorias foram validadas por dois leitores especialistas. Resultados: Nenhum dos participantes tem contrato de trabalho, não tem acesso à segurança social, metade deles já teve bónus em algum momento e apenas um o tem todos os anos. Os trabalhadores domésticos participantes relatam que desconhecem os direitos que a Lei Federal do Trabalho lhes confere, assumem que os benefícios legais são considerações dos empregadores porque são bons empregadores. Não se referem a riscos físicos, químicos, ergonômicos, biológicos ou psicossociais, embora reconheçam sobrecarga de trabalho e alguns desconfortos musculoesqueléticos, fadiga e lesões decorrentes do trabalho. Conclusões: Os empregados domésticos referem entre as suas experiências a ausência de contratos nas suas relações laborais, razão pela qual consideram que essas relações são informais visto que nos seus discursos há expressões como a senhora que o ajudou e não em termos laborais. Os benefícios legais como férias e dias de descanso são concedidos aos trabalhadores, dependendo da necessidade do empregador sem aviso prévio, ou seja, se o empregador tiver que se afastar por motivo de emergência ou férias, então ele decide que esses dias são quando os trabalhadores domésticos será demitido. Quando o acesso à segurança social, às horas extraordinárias ou aos prémios é concedido pelo empregador, é considerado um acto de boa vontade ou um traço de benevolência e não uma obrigação do empregador

Personality and Substance Use in Mexicans and Mexican-Americans

Within the theoretical framework of the five-factor model of personality, existing research identifies personality profiles significantly related to certain at-risk behaviors, such as substance use and poor health outcomes. Among Latinos, there is limited knowledge on whether personality traits are associated with substance use behaviors. This study uses a sample of Mexican (N = 323) and Mexicans American (N = 1,143) participants to examine the interplay of culture and personality differences in relation to substance use and alcohol dependence. Mexican Americans reported higher use of cocaine and marijuana, while Mexicans were more likely to report cigarette smoking. Lower Agreeableness and Conscientiousness were associated with a higher likelihood of substance use and alcohol dependence. Higher Extraversion was associated with higher likelihood of substance use, Openness with marijuana use, and for Neuroticism the associations differed across cultural groups and drug-type used. The study identified cross-cultural communalities and differences in personality traits related to drug use and dependence

Religiosity and religious scrupulosity as markers of poor mental health in the Latinx community: A mediation model

Research shows that religiosity (i.e., identification with and involvement in organized religion) and religious scrupulosity, a type of obsessive–compulsive disorder-like preoccupation with sin and God\u27s wrath, are often misconstrued for one another. As such, the available literature demonstrating a link between religiosity and mental health impairment is likely confounded by the overlap between religiosity and religious scrupulosity. Although this overlap has been examined in other cultural groups, there is no empirical research on this relation within the Latinx community, which continues to grow within the United States. We hypothesized the relation between religiosity and mental health impairment would be fully mediated by religious scrupulosity in the Latinx community. A total of 636 consenting participants (Mage = 21.07, SD = 3.12; 68.55% female), all of whom self-identified as Latinx, completed The Religious Commitment Inventory (i.e., religiosity), Penn Inventory of Scrupulosity-Revised (i.e., religious scrupulosity), and Yale-Brown Obsessive–Compulsive Scale (i.e., clinically significant impairment). Data were analyzed using multiple linear regression analyses with age, gender, and religion serving as covariates. Results supported hypotheses, such that religious scrupulosity explained the significant relation between religiosity and impairment, which disappeared when religious scrupulosity was included as an independent variable in analyses. Results suggest the importance of understanding the distinction between religiosity and religious scrupulosity in the Latinx community, so clinicians do not over-pathologize normal cultural ideals or miss evidence of psychopathology warranting clinical attention

The association between personality traits and body mass index varies with nativity among individuals of Mexican origin

•Personality traits were associated with BMI in ways consistent with the literature.•Some associations were moderated by nativity in this sample of Mexican origin.•Impulsivity was more strongly related to BMI for 2nd generation Mexican-Americans.•Impulsivity was less strongly related to BMI for Mexicans living in Mexico.•Conscientiousness was associated with lower BMI regardless of nativity. Personality traits have been associated consistently with health-related outcomes, but less is known about how aspects of the sociocultural environment modify these associations. This study uses a sample of participants of Mexican origin (N = 1013) to test whether exposure to the United States, indexed by nativity (Mexicans living in Mexico, foreign-born Mexican Americans, and U.S.-born Mexican Americans), moderates the association between personality traits and body mass index (BMI). Higher Conscientiousness was associated with lower BMI, regardless of nativity. In contrast, the association between Neuroticism and BMI was moderated by exposure to the U.S.: Neuroticism was associated with higher BMI among U.S.-born Mexican Americans (partial r = .15) but not among Mexican participants (partial r = .00), an effect strongest and most robust for the impulsivity facet of Neuroticism. This finding suggests that with more exposure to the United States, those who are more emotionally impulsive are at greater risk for obesity. More broadly, these findings suggest that social and psychological vulnerabilities interact to contribute to health outcomes

Promoción de la Salud. Una perspectiva latinoamericana.

La enunciación del concepto Promoción de la Salud remite a una diversidad de experiencias muy disímiles entre sí. Recuperado en la Conferencia Internacional sobre Atención Primaria de Salud, en Alma Ata (1978), como la posibilidad de alcanzar la Salud para TODOS, es comprendida desde diversos sentidos y significados. Los Estados implementan acciones siguiendo acuerdos políticos y de Justicia Social, que sin embargo no logran alcanzar las metas prometidas. En este libro se discuten la historia de la Promoción de la Salud, los antecedentes y alcances de los diferentes documentos emitidos en acuerdos internacionales; los conceptos fundamentales a tener en cuenta: salud como hecho positivo y el papel de la participación comunitaria; los modos de intervención e implementación alcanzados según diferentes paradigmas históricos y en la actualidad, desde la gestión participativa situacional. Se consideran también, las nuevas problemáticas ambientales a partir del cambio climático y la propuesta de Soberanía Alimentaria surgida de organizaciones campesinas y movimientos sociales.Fil. Enria, Graciela María Teresita. Universidad Nacional de Rosario. Rosario; ArgentinaFil. D’Andrea, Lorena Cecilia. Universidad Nacional de Rosario. Facultad de Ciencias Médicas.Rosario; ArgentinaFil. Staffolani, Claudio Mario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas.Rosario; Argentin

Effects of IFIH1 rs1990760 variants on systemic inflammation and outcome in critically ill COVID-19 patients in an observational translational study

Variants in IFIH1, a gene coding the cytoplasmatic RNA sensor MDA5, regulate the response to viral infections. We hypothesized that IFIH1 rs199076 variants would modulate host response and outcome after severe COVID-19. Patients admitted to an intensive care unit (ICU) with confirmed COVID-19 were prospectively studied and rs1990760 variants determined. Peripheral blood gene expression, cell populations, and immune mediators were measured. Peripheral blood mononuclear cells from healthy volunteers were exposed to an MDA5 agonist and dexamethasone ex-vivo, and changes in gene expression assessed. ICU discharge and hospital death were modeled using rs1990760 variants and dexamethasone as factors in this cohort and in-silico clinical trials. About 227 patients were studied. Patients with the IFIH1 rs1990760 TT variant showed a lower expression of inflammation-related pathways, an anti-inflammatory cell profile, and lower concentrations of pro-inflammatory mediators. Cells with TT variant exposed to an MDA5 agonist showed an increase in IL6 expression after dexamethasone treatment. All patients with the TT variant not treated with steroids survived their ICU stay (hazard ratio [HR]: 2.49, 95% confidence interval [CI]: 1.29-4.79). Patients with a TT variant treated with dexamethasone showed an increased hospital mortality (HR: 2.19, 95% CI: 1.01-4.87) and serum IL-6. In-silico clinical trials supported these findings. COVID-19 patients with the IFIH1 rs1990760 TT variant show an attenuated inflammatory response and better outcomes. Dexamethasone may reverse this anti-inflammatory phenotype. Centro de Investigación Biomédica en Red (CB17/06/00021), Instituto de Salud Carlos III (PI19/00184 and PI20/01360), and Fundació La Marató de TV3 (413/C/2021). Patients with severe COVID-19 often need mechanical ventilation to help them breathe and other types of intensive care. The outcome for many of these patients depends on how their immune system reacts to the infection. If the inflammatory response triggered by the immune system is too strong, this can cause further harm to the patient. One gene that plays an important role in inflammation is IFIH1 which encodes a protein that helps the body to recognize viruses. There are multiple versions of this gene which each produce a slightly different protein. It is possible that this variation impacts how the immune system responds to the virus that causes COVID-19. To investigate, Amado-Rodríguez, Salgado del Riego et al. analyzed the IFIH1 gene in 227 patients admitted to an intensive care unit in Spain for severe COVID-19 between March and December 2020. They found that patients with a specific version of the gene called TT experienced less inflammation and were more likely to survive the infection. Physicians typically treat patients with moderate to severe COVID-19 with corticosteroid drugs that reduce the inflammatory response. However, Amado-Rodríguez, Salgado del Riego et al. found that patients with the TT version of the IFIH1 gene were at greater risk of dying if they received corticosteroids. The team then applied the distribution of IFIH1 variants among different ethnic ancestries to data from a previous clinical trial, and simulated the effects of corticosteroid treatment. This 'mock' clinical trial supported their findings from the patient-derived data, which were also validated by laboratory experiments on immune cells from individuals with the TT gene. The work by Amado-Rodríguez, Salgado del Riego et al. suggests that while corticosteroids benefit some patients, they may cause harm to others. However, a real-world clinical trial is needed to determine whether patients with the TT version of the IFIH1 gene would do better without steroids