The walkability of Alvalade neighbourhood for young people: An agent-based model of daily commutes to school

The Alvalade neighbourhood in Lisbon, Portugal, was built in the mid-XX century as low-cost housing for workers, but it has become inhabited by the middle and upper classes. The neighbourhood is home to a large population of young people, including children and teenagers who attend the schools located in the area. We present an agent- based model which aims to investigate the walkability of the neighbourhood for these young people, focusing on the mobility patterns of children and teenagers as they navigate their daily routines of going to school. We simulate the pedestrian movement of these young people, considering factors such as the availability of sidewalks, crosswalks, distance to schools, and the presence of other amenities. Our research reveals the mobility patterns emerging in this area and compares them across the different schools in the area. These results inform both urban policies and interventions that promote safe and accessible routes to school.info:eu-repo/semantics/publishedVersio

Random-walk mobility analysis of Lisbon’s plans for the post-1755 reconstruction

The different options for the reconstruction of the city of Lisbon in the aftermath of the 1755 earthquake are studied with an agent-based model based on randomwalks. This method gives a comparative quantitative measure of mobility of the circulation spaces within the city. The plans proposed for the city of Lisbon signified a departure from the medieval mobility city model. The intricacy of the old city circulation spaces is greatly reduced in the new plans and the mobility between different areas is substantially improved. The simulation results of the random-walk model show that those plans keeping the main force lines of the old city presented less improvement in terms ofmobility. The plans that had greater design freedom were, by contrast, easier to navigate. Lisbon's reconstruction followed a plan that included a shift in the traditional notions of mobility. This affected the daily lives of its citizens by potentiating an easy access to the waterfront, simplifying orientation and navigability. Using the random-walk model it is shown how to quantitatively measure the potential that synthetic plans have in terms of the permeability and navigability of different city public spaces.info:eu-repo/semantics/publishedVersio

Produtividade do meloeiro sob diferentes intervalos de irrigação e disposições de linhas laterais de gotejamento em solo arenoso coeso.

Este trabalho, objetiva oferecer alternativas de reducao nos custos de sistemas de irrigacao por gotejamento de meloeiro, sem afetar o manejo da irrigacao e comparar o gotejamento enterrado, em termos de rendimento da cultura, ao gotejamento superficial. O trabalho foi desenvolvido em um solo arenoso coeso de tabuleiro costeiro, com o delineamento experimental em blocos ao acaso, em parcelas subdivididas, com cinco repeticoes. Os tratamentos consistiram da combinacao de quatro intervalos de irrigacao (1,2,3 e 4 dias) com as linhas laterais de gotejamento junto a fileira de plantas e entre fileiras alternadas de plantas, superficial e enterradas a profundidade de 0,25 m. O intervalo de irrigacao e a disposicao das linhas laterais nao afetaram a produtividade do meloeiro

Myofascial Trigger Points, Pain, Disability, and Sleep Quality in Patients with Chronic Nonspecific Low Back Pain

[EN] Objective: To investigate the difference in the presence of trigger points (TrPs) between patients with chronic nonspecific low back pain (LBP) and healthy people, and to determine the relationship of TrPs with the intensity of ongoing pain, disability, and sleep quality. Design: A cross-sectional study. Setting: The role of TrPs in LBP has not been determined. Patients: Forty-two patients with nonspecific LBP (50% women), aged 23-55 years old, and 42 age- and sex-matched controls participated. Outcome measures: TrPs were bilaterally explored within the quadratus lumborum, iliocostalis lumborum, psoas, piriformis, gluteus minimus, and gluteus medius muscles in a blinded design. TrPs were considered active if the subject recognized the local and referred pain as familiar symptoms, and TrPs were considered latent if the pain was not recognized as a familiar symptom. Pain measures were collected with a numerical pain rate scale, disability was assessed with the Roland-Morris questionnaire, and sleep quality was determined with the Pittsburgh Sleep Quality Index. Results: Patients with nonspecific LBP exhibited a greater disability and worse sleep quality than healthy controls (P < 0.001). Patients with nonspecific LBP exhibited a mean of 3.5 ± 2.3 active TrPs. Further, patients with nonspecific LBP showed a greater (P < 0.001) number of latent TrPs (mean: 2.0 ± 1.5) than healthy controls (mean: 1.0 ± 1.5). Active TrPs in the quadratus lumborum, iliocostalis lumborum, and gluteus medius muscles were the most prevalent in patients with nonspecific LBP. A greater number of active TrPs was associated with higher pain intensity (rs = 0.602; P < 0.001) and worse sleep quality (rs = 0.338; P = 0.03). Conclusions: The local and referred pain elicited by active TrPs in the back and hip muscles contributes to pain symptoms in nonspecific LBP. Patients had higher disability and worse sleep quality than controls. The number of active TrPs was associated with pain intensity and sleep quality. It is possible that a complex interaction among these factors is present in patients with nonspecific LBP

Fsy1, the sole hexose-proton transporter characterized in Saccharomyces yeasts, exhibits a variable fructose:H+ stoichiometry

AbstractIn the model yeast Saccharomyces cerevisiae, hexose uptake is mediated exclusively by a family of facilitators (Hxt, hexose transporters). Some other Saccharomyces species (e.g. Saccharomyces bayanus and Saccharomyces pastorianus) possess, in addition, a specific fructose transporter (Fsy1, fructose symporter) that has been previously described to function as a proton symporter. In the present work, we compared growth of a yeast strain in which FSY1 occurs naturally in anaerobic, fructose- and glucose-limited chemostat cultures. Especially at low specific growth rates, fructose-proton symport was shown to have a strong impact on the biomass yield on sugar. We subsequently employed energized hybrid plasma membrane vesicles to confirm previous observations concerning the mode of operation and specificity of Fsy1 mediated transport. Surprisingly, these experiments suggested that the carrier exhibits an unusual fructose:H+ stoichiometry of 1:2. This energetically expensive mode of operation was also found consistently in vivo, in shake flask and in chemostat cultures, and both when Fsy1 is the sole transporter and when the Hxt carriers are present. However, it is observed only when Fsy1 is operating at higher glycolytic fluxes, a situation that is normally prevented by downregulation of the gene. Taken together, our results suggest the possibility that fructose symport with more than one proton may constitute an energetically unfavorable mode of operation of the Fsy1 transporter that, in growing cultures, is prevented by transcriptional regulation