La diferenciación interna del terciario en el análisis de la funcionalidad de la ciudad.

Sin resume

Geomorphic evolution of the Peninsular Hesperian massif: study of a sector situated between Lugo and Ourense provinces (Galicia, NW Spain)

[Abstract] This paper deals with the relief generation in Ourense, an interior territory of the Galicia Country, at NW Spain, after the breakdown of Pangea 200 million years ago. The rupture of supercontinent causes the main effects in the outer part of Galicia, the present coast line and the shelf, but also the inner parts of Galicia where the landscape changes dramatically mainly ruled by fluvial incision connected with uprising, (orogenic, epirogenic, or isostatic origin), or even with eustatic oscillations, that shaped the previous old mesozoic landscape. Various things complicate the correct understanding of Galician geomorphology:1) the prevalent hercynian structure, (presumably reactivated during the Alpine Orogeny), causes that the epigenic processes, (fluvial, glaciar, marine and etching), acting on Galicia from Mesozoic to present times, produce end forms identified erroneously at the previous literature as tectonic and not as etch forms profiting from lithological or structural contrasts. 2) the common morphotectonic model accepted by all previous researchers establishes for the whole of Galicia a blocky pattern, (horst and graben like), due to extensional tectonic regime. This model is proved as no longer valid because the Galician tertiary basins, even were described at the past as graben depressions never have this origin. 3) big differences exist between the north and western sides of Galicia that show contrasted tectonic regime: compressional (with forms as the so called raised platforms), at the northern coast border, and extensional (with forms so typical as the Rias), at the western side. The study area is located at the confluence of two tectonic domains where the above mentioned effects are coincidents and specially well showed through different effects: prominent assimetry of fluvial captures (west facing), pronounced river incision and different kinds of tertiary basins: either strike slipe faults (Maceda, Xinzo de Limia, etc), or overslipped by inverse faults, Quiroga, A Rúa, etc.), or even corresponding with depressions never, (or anywise passively), affected by tectonic movements, (Monforte). The paper include a detailed inventory of surfaces and terrace levels and their incision sequence which allow stablish a relative chronology of geomorphic evolution at this area of NW Spain during meso-cainozoic times

Automated calibration of FEM models using LiDAR point clouds

In present work it is pretended to estimate elastic parameters of beams through the combined use of precision geomatic techniques (laser scanning) and structural behaviour simulation tools. The study has two aims, on the one hand, to develop an algorithm able to interpret automatically point clouds acquired by laser scanning systems of beams subjected to different load situations on experimental tests; and on the other hand, to minimize differences between deformation values given by simulation tools and those measured by laser scanning. In this way we will proceed to identify elastic parameters and boundary conditions of structural element so that surface stresses can be estimated more easily.Ministerio de Interior | Ref. SPIP2017-02122Ministerio de Economía, Industria y Competitividad | Ref. EUIN2017- 87598Ministerio de Educación, Cultura y Deporte | Ref. CAS15/00126Xunta de Galicia | Ref. ED431C2016‐03

Role of the microtubule-targeting drug vinflunine on cell-cell adhesions in bladder epithelial tumour cells

Background: Vinflunine (VFL) is a microtubule-targeting drug that suppresses microtubule dynamics, showing anti-metastatic properties both in vitro and in living cancer cells. An increasing body of evidence underlines the influence of the microtubules dynamics on the cadherin-dependent cell-cell adhesions. E-cadherin is a marker of epithelial-to-mesenchymal transition (EMT) and a tumour suppressor; its reduced levels in carcinoma are associated with poor prognosis. In this report, we investigate the role of VFL on cell-cell adhesions in bladder epithelial tumour cells. Methods: Human bladder epithelial tumour cell lines HT1376, 5637, SW780, T24 and UMUC3 were used to analyse cadherin-dependent cell-cell adhesions under VFL treatment. VFL effect on growth inhibition was measured by using a MTT colorimetric cell viability assay. Western blot, immunofluorescence and transmission electron microscopy analyses were performed to assess the roles of VFL effect on cell-cell adhesions, epithelial-to-mesenchymal markers and apoptosis. The role of the proteasome in controlling cell-cell adhesion was studied using the proteasome inhibitor MG132. Results: We show that VFL induces cell death in bladder cancer cells and activates epithelial differentiation of the remaining living cells, leading to an increase of E-cadherin-dependent cell-cell adhesion and a reduction of mesenchymal markers, such as N-cadherin or vimentin. Moreover, while E-cadherin is increased, the levels of Hakai, an E3 ubiquitin-ligase for E-cadherin, were significantly reduced in presence of VFL. In 5637, this reduction on Hakai expression was blocked by MG132 proteasome inhibitor, indicating that the proteasome pathway could be one of the molecular mechanisms involved in its degradation. Conclusions: Our findings underscore a critical function for VFL in cell-cell adhesions of epithelial bladder tumour cells, suggesting a novel molecular mechanism by which VFL may impact upon EMT and metastasis

Gender differences in first-year college students’ academic expectations

Based on a multidimensional definition of academic expectations (AEs), the authors examine students’ AE component scores across countries and genders. Two samples (343 Portuguese and 358 Spanish students) completed the Academic Perceptions Questionnaire (APQ) six months after enrolling in their universities. Factorial invariance was ensured across countries and genders, allowing us to study AEs using the APQ for both genders and in both countries. No significant differences in factor means were found between countries, indicating that AEs are not an obstacle to student mobility. Gender differences were found in some AE factor means, Training for employment, Personal and social development, Student mobility, Political engagement and citizenship, and Social pressure, with males exhibiting higher scores. Because these differences are not supported by most literature in this domain, further studies are needed to clarify the causes of women’s lower expectations and, therefore, risk of adaptation difficulties

Natalizumab y Leucoencefalopatía Multifocal Progresiva: adecuación a las recomendaciones del Ministerio de Sanidad de España

Introducción y Objetivo: Valorar el seguimiento de las recomendaciones emitidas por el ministerio de sanidad dirigidas a minimizarel riesgo de aparación de Leucoencefalopatía Multifocal Progresiva (LMP) asociada al tratamiento con natalizumab por parte de losprofesionales sanitarios de nuestro centro. Material y método: Revisión del 100% de pacientes diagnosticados de Esclerosis Múltiple a tratamiento con natalizumab (septiembre2008-junio 2013). Resultados: 34 pacientes. La duración de tratamiento fue inferior a 1 año en 10 pacientes, entre 1 y 2 años para 11 pacientes ysuperior a 2 años en 13 pacientes. Se encuentran 24 resultados de serología VJC: positiva 14 y negativa10. Ningún paciente habíarecibido inmunosupresores y en el 100% de ellos se realizaron resonancias. Fueron informados acerca del riesgo de desarrollar LMP18 pacientes, 10 con serología VJC positiva llevando 7 de ellos más de dos años a tratamiento con natalizumab. Discusión: Los facultativos se ajustan a las recomendaciones en la gran mayoría de los pacientes sin embargo, la información previaal inicio de tratamiento y una vez alcanzados los 2 años no se realiza de manera extendida.Sería adecuado realizar una estratificación de riesgo en función de presencia o ausencia de determinados factores que permitiríauna selección segura y eficaz de la terapia para EM más adecuada para cada paciente