Control strategies for Energy Recovery Ventilators in the South of Europe for residential nZEB. Quantitative analysis of the air conditioning demand

Mechanical ventilation systems are essential for ensuring the indoor quality of air in nZEB (nearly Zero Energy Buildings) with a high level of airtightness. In cold countries, it has already been demonstrated that Heat Recovery Ventilators (HRV) recovering the sensible energy from air ventilation are needed to achieve the energy demand goals for nZEB set by Passivhaus. In tropical areas with hot temperatures and high relative humidity in the ambient air, the necessity of recovering latent and sensible energy with Energy Recovery Ventilators (ERV) has also been demonstrated. However, in warm climates with medium relative humidity levels, for example in cities located on the Mediterranean coast, the evaluation of the effectiveness of an EVR for residential buildings has to be analyzed and optimized. This article establishes the effectiveness of several control strategies for ventilation air systems including ERV with the aim of optimizing the air conditioning energy demand of dwellings located in several cities in the South of Europe. Possible control strategies have been analyzed to minimize the undesirable operation of ERVs which could otherwise increase the air conditioning energy demand for winter and summer seasons. The impact of the latent effectiveness and the effect of free-cooling on the air conditioning energy demand is also studied

Efecto de brasinoesteroides sintéticos en la inducción de callos de arroz

The present work shows the effect of the synthetic brassinosteroids BIOBRAS 6, ME and BIOBRAS 16 in the induction of callus of rice (Oryza sativa L) of the commercial varieties J-104 and Pokkali. Mature seeds were used from both varieties, using MS medium supplemented with 10-5 mg.l-1 of brassinosteroid alone or combined with 2.4 D (2,4-dichlorophenoxyacetic acid) (2 mg.l-1) and Kin (kinetin) (1 mg.l-1). Both varieties formed compact calluses of nodular appearance and white color, ligth yellow-yellow; achieving in the best treatments 50 and 90 percent of induction in Pokkali and J-104 respectively. Showing a possible citoquinin behavior of the brasinoesteroides studied in the process of calluses induction .The BIOBRAS 6 turned to be a substitute of the Kin in the induction of callus of both varieties while the ME had the same effect in J-104, on the other hand the BIOBRAS 16 was inhibitory.Key words: 2,4-dichlorophenoxyacetic acid, callogenesis,El presente trabajo tuvo como propósito evaluar el efecto de los brasinoesteroides sintéticos BIOBRAS 6, ME y BIOBRAS 16 en la inducción de callos de arroz (Oryza sativa L) de las variedades comerciales J-104 y Pokkali, Para ello se utilizaron semillas maduras de ambas variedades, empleándose el medio de cultivo MS suplementado con 10-5 mg.l-1 de brasinoesteroide, sólo o combinado con 2,4 D (ácido 2,4-diclorofenoxiacético) (2 mg.l-1) y Kin (Kinetina) (1 mg.l-1). Ambas variedades formaron callos compactos de apariencia nodular y color blanco, amarillo-amarillo pálido; alcanzándose en los mejores tratamientos un 90 y 50% de inducción en Pokkali y J-104 respectivamente. El BIOBRAS 6 resultó ser un sustituto de la Kin en la inducción de callos de ambas variedades mientras que el ME tuvo el mismo efecto en J-104, el BIOBRAS 16 fue inhibitorio.Palabras clave: ácido 2,4-diclorofenoxiacético, callogénesis, kinetin

Functional differences found in the elderly living in the community

Introduction: Successful aging lies in cognitive and functional maintenance, and in the optimal performance of daily tasks that keep the elderly free of disability and dependence. However, there is little evidence for functional differences for gender and age, and how cognitive and physical demands in past working lives can affect them, to design more personalized occupational therapy interventions to prevent functional and cognitive impairment. Method: This observational descrip-tive study evaluated 367 older adults living in a community with subjective memory complaints and scored between 24 and 35 with the Spanish version of the “Mini-Mental State Examination (MEC-35)”. Basic activities of daily living (BADL) were studied with the Barthel Index, while instrumental ADL (IADL) were examined with the Lawton–Brody scale. Functional differences for gender, age, and physico-mental occupation were examined. Results: The significant differences found for gender indicated that men did better in BADL (p = 0.026) and women better performed IADL (p < 0.001). Differences between age groups suggest that the younger group (aged 64–75) obtained better results for BADL (p = 0.001) and IADL (p < 0.001). For physico-mental occupation, statistically significant differences were found only in IADL for mental (p = 0.034) and physical occupation (p = 0.005). Conclusions: Gender, age, and the cognitive and physical demands of occupational stages, can be important predictors of cognitive and functional impairment. These results can be generalized to other health centers in the province and to other Spanish Autonomous Communities because their socio-demographic variables are similar. It would be interesting to carry out multimodal personalized interventions that consider the factors that might affect functional impairment to preserve personal autonomy. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

Ice-rafted dropstones at midlatitudes in the Cretaceous of continental Iberia

The Cretaceous is widely considered to have been a period subjected to super-greenhouse conditions. Here, we provide multiscale sedimentologic evidence of glaciers developing at mid-paleolatitudes (∼45°N) in continental Iberia during the Hauterivian cold snap. Striated and faceted ice-rafted glacial dropstones (cobble to boulder size) and striated and grooved silt- to sand-sized grains (ice-rafted debris [IRD]) occur in a lacustrine sequence of the Enciso Group in the eastern Cameros Basin, Spain. The ice-rafted materials constitute the first evidence reported for a Cretaceous continental cryospheric record in Europe, and they are attributed to calving of glacier snouts, releasing icebergs into an ice-contact lake. The sedimentary succession resembles glacial-deglacial records in lakes overridden by the late Pleistocene Laurentide Ice Sheet in eastern Arctic Canada. The Iberian glacial succession was coeval with plateau permafrost in Asia and IRD records in the Arctic and Australia, revealing a stronger than previously thought cryosphere during the global Hauterivian cold snap

Interstitial cells of Cajal and enteric nervous system in gastrointestinal and neurological pathology. Relation to oxidative stress

The enteric nervous system (ENS) is organized into two plexuses—submucosal and myenteric—which regulate smooth muscle contraction, secretion, and blood flow along the gastrointestinal tract under the influence of the rest of the autonomic nervous system (ANS). Interstitial cells of Cajal (ICCs) are mainly located in the submucosa between the two muscle layers and at the intramuscular level. They communicate with neurons of the enteric nerve plexuses and smooth muscle fibers and generate slow waves that contribute to the control of gastrointestinal motility. They are also involved in enteric neurotransmission and exhibit mechanoreceptor activity. A close relationship appears to exist between oxidative stress and gastrointestinal diseases, in which ICCs can play a prominent role. Thus, gastrointestinal motility disorders in patients with neurological diseases may have a common ENS and central nervous system (CNS) nexus. In fact, the deleterious effects of free radicals could affect the fine interactions between ICCs and the ENS, as well as between the ENS and the CNS. In this review, we discuss possible disturbances in enteric neurotransmission and ICC function that may cause anomalous motility in the gut

Revisión y mejora de la caracterización del grado de impermeabilidad requerido por el CTE DB-HS1 para fachadas de edificación

El Código Técnico de la Edificación aprobado en 2006, asigna por primera vez en España diferentes requisitos básicos para los cerramientos verticales de edificación, destinados a limitar el riesgo de presencia inadecuada de humedad en el interior de los edificios. La solicitación por humedad, estimada mediante diversos parámetros climáticos, permite ajustar la exigencia de estos requisitos para cada emplazamiento y fachada. Sin embargo, estos parámetros presentan actualmente posibilidades de mejora que pueden dar lugar a una asignación más adecuada del grado de impermeabilidad y con ello, de los requisitos de diseño necesarios. Este artículo revisa estos parámetros climáticos, presenta otros utilizados internacionalmente para el mismo propósito y caracteriza en el territorio español los factores que determinan la solicitación por humedad, haciendo posible mejorar la prestacionalidad de los requisitos básicos impuestos para las fachadas de los edificios. The Spanish Technical Building Code published in 2006 regulates the basic requirements of building façades to prevent the inadequate presence of atmospheric water inside Spanish buildings. The moisture exposure estimate, based on several climate parameters, allows adjusting these requirements for every location and façade. However, the parameters used by the Spanish Code can be improved, resulting in a more appropriate estimate of the required water tightness degree and thus in an improvable allocations of the necessary design conditions. This paper reviews these parameters, presenting other internationally applied, and analyses the moisture exposure in the Spanish territory, which would allow improving the subsequent performance of the basic requirements imposed to the façades

Dependence on plasma shape and plasma fueling for small ELM regimes in TCV and ASDEX Upgrade

Within the EUROfusion MST1 Work Package, a series of experiments has been conducted on AUG and TCV devices to disentangle the role of plasma fueling and plasma shape for the onset of small ELM regimes. On both devices, small ELM regimes with high confinement are achieved if and only if two conditions are fulfilled at the same time. Firstly, the plasma density at the separatrix must be large enough (ne,sep/nG ∼ 0.3), leading to a pressure profile flattening at the separatrix, which stabilizes type-I ELMs. Secondly, the magnetic configuration has to be close to a Double Null (DN), leading to a reduction of the magnetic shear in the extreme vicinity of the separatrix. As a consequence, its stabilizing effect on ballooning modes is weakened.EURATOM 63305

Prognostic significance of FLT3-ITD length in AML patients treated with intensive regimens

FLT3-ITD mutations are detected in approximately 25% of newly diagnosed adult acute myeloid leukemia (AML) patients and confer an adverse prognosis. The FLT3-ITD allelic ratio has clear prognostic value. Nevertheless, there are numerous manuscripts with contradictory results regarding the prognostic relevance of the length and insertion site (IS) of the FLT3-ITD fragment. We aimed to assess the prognostic impact of these variables on the complete remission (CR) rates, overall survival (OS) and relapse-free survival (RFS) of AML patients with FLT3-ITDmutations. We studied the FLT3-ITD length of 362 adult AML patients included in the PETHEMA AML registry. We tried to validate the thresholds of ITD length previously published (i.e., 39 bp and 70 bp) in intensively treated AML patients (n = 161). We also analyzed the mutational profile of 118 FLT3-ITD AML patients with an NGS panel of 39 genes and correlated mutational status with the length and IS of ITD. The AUC of the ROC curve of the ITD length for OS prediction was 0.504, and no differences were found when applying any of the thresholds for OS, RFS or CR rate. Only four out of 106 patients had ITD IS in the TKD1 domain. Our results, alongside previous publications, confirm that FLT3-ITD length lacks prognostic value and clinical applicability. © 2021, The Author(s)

Role of age and comorbidities in mortality of patients with infective endocarditis

Purpose: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. Methods: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015. Patients were stratified into three age groups:<65 years, 65 to 80 years, and = 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. Results: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 = 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients =80 years who underwent surgery were significantly lower compared with other age groups (14.3%, 65 years; 20.5%, 65-79 years; 31.3%, =80 years). In-hospital mortality was lower in the <65-year group (20.3%, <65 years;30.1%, 65-79 years;34.7%, =80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%, =80 years; p = 0.003).Independent predictors of mortality were age = 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI = 3 (HR:1.62; 95% CI:1.39–1.88), and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared, the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. Conclusion: There were no differences in the clinical presentation of IE between the groups. Age = 80 years, high comorbidity (measured by CCI), and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group