1,531 research outputs found

    THE UNIVERSITY AS A COMMON POOL RESOURCE: a set of resources, moral and cultural values from the Academic Community of Universidad Politécnica Salesiana

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    This book contains information from Universidad Politecnica Salesiana’s Commons Research Group, created in 2016 to deepen as well as identify the implication and the possibilities of imagining the university as a “common pool resource” . This alternative must be explained because the connection of the use of commons – as explained by Elinor Ostrom in her book Governing the Commons. The evolution of institutions for Collective Action (2011) – with the possibility of reconsidering the university in all areas is not immediate nor casual and, at first, such connection seems odd in a time when we value belonging based on evidence accessible at first sight. In fact, what does a proposal which analyzes community and local government decision making methods regarding common resources have to do with university life? The aim of this preface is to answer this question and explain the connection that encourages and gives meaning to several contributions of this book. Each contribution deepens its derivations in the field of management, decision making and knowledge production

    Recensiones [Revista de Historia Económica Año XX Otoño-Invierno 2002 n. 3 pp. 649-689]

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    Editada en la Fundación Empresa PúblicaGonzález Enciso, A. (ed.): El negocio de la lana en España (1650-1830) (Por Emilio Pérez Romero).-- Marichal, C, y Marino, D. (comps.): De colonia a nación. Impuestos y política en México, 1750-1860 (Por Rafael Dobado).-- Martín, J. L. (dir.), y Robledo, R. (coord.): Historia de Salamanca, IV. Siglo XIX (Por Enrique Llopis Agelán).-- Carmona, J.: Aristocracia terrateniente y cambio agrario en la España del siglo XIX (Por Richard Herr).-- Martorell, M.: Historia de la peseta. La España contemporánea a través de su moneda (Por Pablo Martín Aceña).-- Cabrera, M., y del Rey, F.: El poder de los empresarios. Política y economía en la España contemporánea (1875-2000) (Por Eugenio Torres).-- Gálvez, L.: Compañía Arrendataria de Tabacos (1887-1945). Cambio tecnológico y empleo femenino (Por Luciano Segreto).-- Vivenza, G.: Adam Smith and the Classics. The Classical Heritage in Adam Smith's Thought (Por Carlos Rodríguez Braun).-- O'Rourke, K., y Williamson, J. G.: Globalization and History. The Atlantic Economy in the Nineteenth Century (Por Leandro Prados de la Escosura).-- Hayes, P.: Industry and Ideology. IG Farben in the Nazi Era (Por Nuria Puig)Publicad

    Hippo pathway effectors YAP1/TAZ induce an EWS–FLI1‐opposing gene signature and associate with disease progression in Ewing sarcoma

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    YAP1 and TAZ (WWTR1) oncoproteins are the final transducers of the Hippo tumor suppressor pathway. Deregulation of the pathway leads to YAP1/TAZ activation fostering tumorigenesis in multiple malignant tumor types, including sarcoma. However, oncogenic mutations within the core components of the Hippo pathway are uncommon. Ewing sarcoma (EwS), a pediatric cancer with low mutation rate, is characterized by a canonical fusion involving the gene EWSR1 and FLI1 as the most common partner. The fusion protein is a potent driver of oncogenesis, but secondary alterations are scarce, and little is known about other biological factors that determine the risk of relapse or progression. We have observed YAP1/TAZ expression and transcriptional activity in EwS cell lines. Analyses of 55 primary human EwS samples revealed that high YAP1/TAZ expression was associated with progression of the disease and predicted poorer outcome. We did not observe recurrent SNV or copy number gains/losses in Hippo pathway‐related loci. However, differential CpG methylation of the RASSF1 locus (a regulator of the Hippo pathway) was observed in EwS cell lines compared with mesenchymal stem cells, the putative cell of origin of EwS. Hypermethylation of RASSF1 correlated with the transcriptional silencing of the tumor suppressor isoform RASFF1A, and transcriptional activation of the pro‐tumorigenic isoform RASSF1C, which promotes YAP1/TAZ activation. Knockdown of YAP1/TAZ decreased proliferation and invasion abilities of EwS cells and revealed that YAP1/TAZ transcription activity is inversely correlated with the EWS–FLI1 transcriptional signature. This transcriptional antagonism could be explained partly by EWS–FLI1‐mediated transcriptional repression of TAZ. Thus, YAP1/TAZ may override the transcriptional program induced by the fusion protein, contributing to the phenotypic plasticity determined by dynamic fluctuation of the fusion protein, a recently proposed model for disease dissemination in EwS

    LA UNIVERSIDAD: UN BIEN DE USO COMÚN. Conjunto de recursos, valores morales y culturales de la Comunidad Académica de la Universidad Politécnica Salesiana

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    El colectivo de autores, docentes y autoridades de la Universidad Politécnica Salesiana del Ecuador, se ha propuesto repensar la universidad —especialmente la universidad católica— como un bien de uso común a la luz de los aportes del premio Nobel de Economía (2009) Elinor Ostrom, quien analiza el gobierno de los bienes comunes en las instituciones de acción colectiva. A partir de imaginar la Universidad Politécnica Salesiana como un Recurso de Uso Común (RUC), y pensar su trayectoria de desarrollo y educación intercultural en las comunidades andinas y amazónicas, cada uno de los artículos profundiza las derivaciones en el ámbito de la identidad institucional, gestión, toma de decisiones y la producción de conocimiento. El libro enriquece la visión institucional de Ostrom y alimenta la noción de la universidad en tanto comunidad académica que genera pertenencias y territorialidades, de diverso tipo así como formas de gestión y organización derivadas de un sentido previo que obliga a reconsiderar la autonomía universitaria y los mecanismos de toma de decisiones

    Recensiones [ Revista de Historia Económica Año XIII Otoño 1995 n. 3 pp. 655-708]

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    Editada en la Fundación Empresa PúblicaGabriel Tortella. El desarrollo de la España contemporánea: Historia económica de los siglos XIX y XX (Por Richard Herr).-- Mercedes Cabrera. La industria, la prensa y la política, Nicolás María Urgoiti (1869- 1931) (Por Juan Pablo Fusi Aizpurúa).-- Juan Hernández Andreu y José Luis García Ruiz. Lecturas de Historia empresarial (Por Gregorio Núñez Romero-Balmas).-- Luis Javier Coronas Vida. La economía agraria de las tierras de Jaén (1500-1630) (Por Luis Garrido González).-- José Manuel Castaño Blanco. Sayago a la luz del Catastro de Ensenada. Respuestas Generales. Luis Ángel Sánchez Gómez. Sayago. Ganadería y comunalismo agropastoril. Luis Ángel Sánchez Gómez. Las dehesas de Sayago. Explotación, trabajo y estructura social (Por Ricardo Robledo).-- Pedro Sanz Legaristi. El ferrocarril anglo-vasco y la Restauración en Álava (ISHO- 1931) (Por Carlos Larrinaga Rodríguez).-- Antonio López Ontiveros y Rafael Mata Olmo. Propiedad de la tierra y reforma agraria en Córdoba (1932-1936) (Por Luis Enrique Espinoza Guerra).-- COMPAÑÍA SEVILLANA DE ELECTRICIDAD. Cien años de historia (Por Juan Manuel Mates Barco).-- Eugenia Matas. AS Finanças Públicas portuguesas da Regeneragao a Primeira Guerra Mundial. Nuno Valerio. As Finanças Públicas portuguesas entre as duas guerras mundiais. (Por Francisco Comín).-- Jaime Reis. O atraso económico portugués em perspectiva histórica: estudos sobre a economía portuguesa na segunda metade do século XIX (1830-1930) (Por Santiago Zapata Blanco).-- Juan Carlos Garavaglia y Juan Carlos Grosso. Puebla desde una perspectiva microhistórica. La villa de Tepeaca y su entorno agrario: población, producción e intercambio (1740-1870) (Por Carlos Marichal).-- Carmelo Mesa-Lago. Breve Historia económica de la Cuba Socialista. Políticas, resultados y perspectivas (Por Doria González Fernández).-- Phyllis Deane. El Estado y el sistema económico. Introducción a la historia de la economía política (Por Carlos Rodríguez Braun).-- Lorenzo del Planta y Rosella Rettaroli. Introduzione alia demografía storica (Por Josep Bernabeu Mestre).-- Claudia Goldin y Hugh Rockoft. Strategic Factors in Nineteenth Century American Economic History: A volume to honor R. W. Fogel (Por Alfonso Díaz).-- John Habakkuk. Marriage, Debt, and the Estates System. English Landownership 1630-1930 (Por Juan Carmona).-- Forrest H. Capie. Tariffs and growth. Some ilustration from the ivorld economy 1830-1940 (Por Antonio Tena).-- Michael D. Bordo y Barry Eichengreen. A Retrospectíve on the Bretton Woods System: Lessons for International Monetary Reform (Por Félix Várela Parache)Publicad

    Twenty years of ground-based NDACC FTIR spectrometry at Izaña Observatory - overview and long-term comparison to other techniques

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    High-resolution Fourier transform infrared (FTIR) solar observations are particularly relevant for climate studies, as they allow atmospheric gaseous composition and multiple climate processes to be monitored in detail. In this context, the present paper provides an overview of 20 years of FTIR measurements taken in the framework of the NDACC (Network for the Detection of Atmospheric Composition Change) from 1999 to 2018 at the subtropical Izaña Observatory (IZO, Spain). Firstly, long-term instrumental performance is comprehensively assessed, corroborating the temporal stability and reliable instrumental characterization of the two FTIR spectrometers installed at IZO since 1999. Then, the time series of all trace gases contributing to NDACC at IZO are presented (i.e. C2H6, CH4, ClONO2, CO, HCl, HCN, H2CO, HF, HNO3, N2O, NO2, NO, O3, carbonyl sulfide (OCS), and water vapour isotopologues H162O, H182O, and HD16O), reviewing the major accomplishments drawn from these observations. In order to examine the quality and long-term consistency of the IZO FTIR observations, a comparison of those NDACC products for which other high-quality measurement techniques are available at IZO has been performed (i.e. CH4, CO, H2O, NO2, N2O, and O3). This quality assessment was carried out on different timescales to examine what temporal signals are captured by the FTIR records, and to what extent. After 20 years of operation, the IZO NDACC FTIR observations have been found to be very consistent and reliable over time, demonstrating great potential for climate research. Long-term NDACC FTIR data sets, such as IZO, are indispensable tools for the investigation of atmospheric composition trends, multi-year phenomena, and complex climate feedback processes, as well as for the validation of past and present space-based missions and chemistry climate models.The Izaña FTIR station has been supported by the German Bundesministerium für Wirtschaft und Energie (BMWi) via DLRunder grants 50EE1711A and by the Helmholtz Society via the research program ATMO. In addition, this research was funded by the European Research Council under FP7/(2007-2013)/ERC Grant agreement nº 256961 (project MUSICA), by the Deutsche Forschungsgemeinschaft for the project MOTIV (GeschaFTIRzeichen SCHN 1126/2-1), by the Ministerio de Economía y Competitividad from Spain through the projects CGL2012-37505 (project NOVIA) and CGL2016-80688-P (project INMENSE), and by EUMETSAT under its Fellowship Programme (project VALIASI)

    Izaña Atmospheric Research Center. Activity Report 2019-2020

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    Editors: Emilio Cuevas, Celia Milford and Oksana Tarasova.[EN]The Izaña Atmospheric Research Center (IARC), which is part of the State Meteorological Agency of Spain (AEMET), is a site of excellence in atmospheric science. It manages four observatories in Tenerife including the high altitude Izaña Atmospheric Observatory. The Izaña Atmospheric Observatory was inaugurated in 1916 and since that date has carried out uninterrupted meteorological and climatological observations, contributing towards a unique 100-year record in 2016. This reports are a summary of the many activities at the Izaña Atmospheric Research Center to the broader community. The combination of operational activities, research and development in state-of-the-art measurement techniques, calibration and validation and international cooperation encompass the vision of WMO to provide world leadership in expertise and international cooperation in weather, climate, hydrology and related environmental issues.[ES]El Centro de Investigación Atmosférica de Izaña (CIAI), que forma parte de la Agencia Estatal de Meteorología de España (AEMET), representa un centro de excelencia en ciencias atmosféricas. Gestiona cuatro observatorios en Tenerife, incluido el Observatorio de Izaña de gran altitud, inaugurado en 1916 y que desde entonces ha realizado observaciones meteorológicas y climatológicas ininterrumpidas y se ha convertido en una estación centenaria de la OMM. Estos informes resumen las múltiples actividades llevadas a cabo por el Centro de Investigación Atmosférica de Izaña. El liderazgo del Centro en materia de investigación y desarrollo con respecto a las técnicas de medición, calibración y validación de última generación, así como la cooperación internacional, le han otorgado una reputación sobresaliente en lo que se refiere al tiempo, el clima, la hidrología y otros temas ambientales afines

    A search for an unexpected asymmetry in the production of e(+)mu(-) and e(-)mu(+) pairs in proton-proton collisions recorded by the ATLAS detector at root s=13 TeV

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    This search, a type not previously performed at ATLAS, uses a comparison of the production cross sections for e(+)mu(-) and e(-)mu(+) pairs to constrain physics processes beyond the Standard Model. It uses 139 fb(-1) of proton-proton collision data recorded at root s = 13 TeV at the LHC. Targeting sources of new physics which prefer final states containing e(+)mu(-) and e(-)mu(+), the search contains two broad signal regions which are used to provide model-independent constraints on the ratio of cross sections at the 2% level. The search also has two special selections targeting supersymmetric models and leptoquark signatures. Observations using one of these selections are able to exclude, at 95% confidence level, singly produced smuons with masses up to 640 GeV in a model in which the only other light sparticle is a neutralino when the R-parity-violating coupling lambda(23)(1)' is close to unity. Observations using the other selection exclude scalar leptoquarks with masses below 1880 GeV when g(1R)(eu) = g(1R)(mu c) = 1, at 95% confidence level. The limit on the coupling reduces to g(1R)(eu) = g(1R)(mu c) = 0.46 for a mass of 1420 GeV
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