Multi-homing tunnel broker

A proper support for communications has to provide fault tolerance capabilities such as the preservation of established connections in case of failures. Multihoming addresses this issue, but the currently available solution based in massive BGP route injection presents serious scalability limitations, since it contributes to the exponential growth of the BGP table size. An alternative solution based on the configuration of tunnels between the multihomed site exit routers and the ISP border routers has been proposed for IPv6 in RFC 3178. However, the amount of manual configuration imposed by this solution on the ISP side prevents its wide adoption. In particular, this solution requires at the ISP the manual configuration of a tunnel endpoint per each multihomed client that it serves. We present a multihoming tunnel broker (MHTB) that provides automatic creation of the tunnel endpoint at the ISP side.This work was supported by the SAM (Advanced Servers with Mobility)project, funded by the Spanish National research and Development Programme as TIC2002-04531-C04-03.Publicad

Sensitization to isothiazolinones in the Spanish Contact Dermatitis Registry (REIDAC): 2019–2021 epidemiological situation

Background: Current frequency and risk factors for sensitization to methylisothiazolinone (MI), methylchloroisothiazolinone/methylisothiazolinone (MCI/MI), benzisothiazolinone (BIT) and octylisothiazolinone (OIT) in Spain are not well known. Objectives: To study the frequency of sensitization, risk factors and simultaneous sensitization between the four isothiazolinones. Materials and Methods: We analysed all 2019-2021 consecutive patients patch-tested with MI (0.2% aq.), MCI/MI (0.02% aq.), BIT (0.1% pet.) and OIT (0.1% pet) within the Spanish Contact Dermatitis Registry (REIDAC). Results: A total of 2511 patients were analysed. Frequencies of sensitization were: any isothiazolinone 15.7%, MI 6.8%, MCI/MI 4.8%, BIT 3.5% and OIT 0.5%. MI and MCI/MI sensitization was associated with being occupationally active, hand dermatitis, detergents and age over 40. BIT sensitization was associated with leg dermatitis and age over 40. About one in nine MI-positive patients were positive to BIT, whereas one in five BIT-positive patients were positive to MI. Conclusions: Sensitization to MI, MCI/MI and BIT is still common in Spain, while sensitization to OIT is rare. Currently, sensitization to MI and MCI/MI seems to be occupationally related. Although its origin is unknown, sensitization to BIT is more frequent in patients aged over 40 years. Simultaneous sensitization between MI and BIT is uncommon.The Spanish Registry of Contact Dermatitis (REIDAC) is promoted by the Fundación Piel Sana (Academia Española de Dermatología y Venereología), which has received financial support from the Spanish Medicines and Health Products Agency (Agencia Española de Medicamentos y Productos Sanitarios. https://www.boe.es/boe/dias/2022/04/11/pdfs/BOE-A-2022-5975.pdf) and Sanofi. The funders were not involved in the design and conduct of the study, collection, management, analysis and interpretation of data, preparation, review, approval of the manuscript, or decision to submit the manuscript for publication

Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-alpha 2 in 10 patients: IFN-alpha 2 only in three, IFN-alpha 2 plus IFN-omega in five, and IFN-alpha 2, IFN-omega plus IFN-beta in two; IFN-omega only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-alpha 2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-omega in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-alpha 2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-. only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-omega and/or IFN-alpha 2

Implantación de IPv6 : red, mecanismos de transición IPv4-IPv6, servicios de aplicación y migración de aplicaciones

El presente proyecto fin de carrera trata los aspectos más importantes de la gestión y migración de las redes IP hacia el nuevo protocolo de red IPv6 y pone gran énfasis en experiencias de implantación de los mismos. A lo largo de este proyecto se profundiza sobre los distintos mecanismos de transición IPv4/IPv6 existentes, concretamente se describen y se prueban (en entornos Linux y FreeBSD) los siguientes: .Túneles 6t04, automáticos, configurados. .Mecanismo DSTM, TRT, ISATAP, NAT-PT. También se presentan y se implantan en un entorno operativo servicios de red ofrecidos a través de la nueva plataforma IPv6, entre los que podemos citar: DNS, Servidor web, Red de servidores de IRC, Servicio de NFS. Se demuestra su funcionamiento en entornos mixtos IPv4/IPv6, diseñando escenarios que hacen uso de los mecanismos de traducción o encapsulación explicados en el presente proyecto fin de carrera. También se discuten y se implantan los protocolos de encaminamiento RIP y BGP en sus modalidades para IPv6 y se comenta la participación de nuestra red IPv6 de pruebas dentro de la red de pruebas multicast para IPv6 a nivel mundial, denominada m6bone. Se finaliza el presente trabajo con la migración al nuevo protocolo de la herramienta generadora de paquetes IP denominada MGEN, junto con la migración de las siguientes aplicaciones: .Servidor (FICS) y cliente de ajedrez (xboard). .Implementación de una simulación de ping encapsulado utlizando el mecanismo de transición "6t04". A lo largo de todo el proyecto se presentan recomendaciones para la implantación del nuevo protocolo, las dificultades que ralentizan su implantación y los beneficios que se pretenden obtener, así como las decisiones más importantes tomadas hasta la fecha.Ingeniería en Informátic