Alkalinity and pH measurements during the Ovide 2010 on board R/V Thalassa, 8 June and 8 July 2010

7 páginasThe carbon system is defined by four variables: pH, Total Alkalinity (AT), partial pressure of carbon dioxide (pCO2) and Total Inorganic Carbon (CT). The knowledge of two of these variables allows calculating the other two by means of a set of equations deduced from thermodynamic equilibrium. During the OVIDE 2010 cruise pH and AT measurements were sampled from bottle depths at selected stations (table 1) and analysed on board. Also, to check the internal consistence, 35 samples for CT were also taken in 7 stations along the section and will be analysed at laboratory. This report resumes the activities, methods and first results obtained during the OVIDE 2010 cruise. This cruise was carried out between 8 June and 8 July on board the R/V ThalassaPeer reviewe

Assessment of the Extrusion Process and Printability of Suspension-Type Drug-Loaded AffinisolTM Filaments for 3D Printing

Three-dimensional (3D) printing technology enables the design of new drug delivery systems for personalised medicine. Polymers that can be molten are needed to obtain extruded filaments for Fused Deposition Modelling (FDM), one of the most frequently employed techniques for 3D printing. The aim of this work was to evaluate the extrusion process and the physical appearance of filaments made of a hydrophilic polymer and a non-molten model drug. Metformin was used as model drug and Affinisol™ 15LV as the main carrier. Drug-loaded filaments were obtained by using a single-screw extruder and, subsequently, their printability was tested. Blends containing up to a 60% and 50% drug load with 5% and 7.5% of auxiliary excipients, respectively, were successfully extruded. Between the obtained filaments, those containing up to 50% of the drug were suitable for use in FDM 3D printing. The studied parameters, including residence time, flow speed, brittleness, and fractal dimension, reflect a critical point in the extrusion process at between 30–40% drug load. This finding could be essential for understanding the behaviour of filaments containing a non-molten component

Procedimiento, cuidado y manejo del catéter central de inserción periférica (PICC) en adultos. FEMORA

O programa FEMORA recompila procedementos estandarizados, con evidencia científica, para os profesionais do Sergas. A protocolización dos coidados confórmase como instrumento indispensable de soporte para a práctica clínica. Entre as súas numerosas vantaxes cabe destacar a redución na diversidade inapropiada da práctica clínica, o que propicia unha atención máis xusta e equitativa aos pacientes. Este procedemento unifica, así mesmo, criterios de actuación que serven de punto de partida para unha avaliación de calidade do proceso asistencial.El programa FEMORA recopila procedimientos estandarizados, con evidencia científica, para los profesionales del Sergas. La protocolización de los cuidados se conforma como instrumento indispensable de soporte para la práctica clínica. Entre sus numerosas ventajas cabe destacar la reducción en la diversidad inapropiada de la práctica clínica, lo que propicia una atención más justa y equitativa a los pacientes. Este procedimiento unifica asimismo, criterios de actuación que sirven de punto de partida para una evaluación de calidad del proceso asistencial

Procedimiento de inserción del catéter central de inserción periférica (PICC) en adultos FEMORA. Procedimientos de enfermería: canalización y cuidados de vías vasculares

O programa FEMORA recompila procedementos estandarizados, con evidencia científica, para os profesionais do Sergas. A protocolización dos coidados confórmase como instrumento indispensable de soporte para a práctica clínica. Entre as súas numerosas vantaxes cabe destacar a redución na diversidade inapropiada da práctica clínica, o que propicia unha atención máis xusta e equitativa aos pacientes. Este procedemento unifica, así mesmo, criterios de actuación que serven de punto de partida para unha avaliación de calidade do proceso asistencial.El programa FEMORA recopila procedimientos estandarizados, con evidencia científica, para los profesionales del Sergas. La protocolización de los cuidados se conforma como instrumento indispensable de soporte para la práctica clínica. Entre sus numerosas ventajas cabe destacar la reducción en la diversidad inapropiada de la práctica clínica, lo que les propicia una atención más justa y equitativa a los pacientes. Este procedimiento unifica, asimismo, criterios de actuación que sirven de punto de partida para una evaluación de calidad del proceso asistencial

Air-sea CO2 fluxes in the Atlantic as measured during the FICARAM cruises

A total of fourteen hydrographic cruises spanning from 2000 to 2008 were conducted during the spring and autumn seasons between Spain and the Southern Ocean, under the framework of the Spanish research project FICARAM. The performed underway measurements are processed and analysed to describe the meridional air-sea CO2 fluxes (F CO2) along the Atlantic Ocean. The data was organised into different biogeochemical oceanographic provinces, according mainly to the thermohaline characteristics. The obtained spatial and temporal distributions of F CO2 follow the generally expected patterns and annual trends. The Subtropical regions in both hemispheres alternated the CO2 source and sink nature from autumn to spring, respectively. On the other hand, Tropical waters and the Patagonian Sea clearly behaved as sinks of atmospheric CO2 like the waters of the Drake Passage during autumn. The obtained results during the cruises also revealed significant long-term trends, such as the warming of equatorial waters (0.11±0.03 Cyr−1) and the decrease of surface salinity (−0.16±0.01 yr−1) in tropical waters caused by the influence of the Amazon River plume. This reduction in surface salinity appears to have a direct influence over the CO2 storage rates, fostering the uptake capacity of atmospheric CO2 (−0.09±0.03 molm−2 yr−1). An analysis of the biogeochemical forcing on the CO2 fugacity (fCO2) variability performed from an empirical algorithm highlighted the major role of the Amazon River input in the tropical North Atlantic fluxes. In addition, it has provided a quantitative measure of the importance of the thermodynamic control of F CO2 at temperate latitudes

Association of Functional Polymorphisms of KIR3DL1/DS1 With Behçet's Disease

Behçet's disease (BD) is an immune-mediated vasculitis related to imbalances between the innate and adaptive immune response. Infectious agents or environmental factors may trigger the disease in genetically predisposed individuals. HLA-B51 is the genetic factor stronger associated with the disease, although the bases of this association remain elusive. NK cells have also been implicated in the etiopathogenesis of BD. A family of NK receptors, Killer-cell Immunoglobulin-like Receptor (KIR), with a very complex organization, is very important in the education and control of the NK cells by the union to their ligands, most of them, HLA class I molecules. This study aimed to investigate the contribution of certain KIR functional polymorphisms to the susceptibility to BD. A total of 466 BD patients and 444 healthy individuals were genotyped in HLA class I (A, B, and C). The set of KIR genes and the functional variants of KIR3DL1/DS1 and KIR2DS4 were also determined. Frequency of KIR3DL1004 was lower in patients than in controls (0.15 vs. 0.20, P = 0.005, Pc = 0.015; OR = 0.70; 95% CI 0.54-0.90) in both B51 positive and negative individuals. KIR3DL1004, which encodes a misfolded protein, is included in a common telomeric haplotype with only one functional KIR gene, KIR3DL2. Both, KIR3DL1 and KIR3DL2 sense pathogen-associated molecular patterns but they have different capacities to eliminate them. The education of the NK cells depending on the HLA, the balance of KIR3DL1/KIR3DL2 licensed NK cells and the different capacities of these receptors to eliminate pathogens could be involved in the etiopathogenesis of BD

Comunicación y polialfabetismo Aportes desde el saber pedagógico para la educación del siglo XXI

144 páginas. Libro electrónicoLa línea de Comunicación y polialfabetismos presenta en las experiencias de aula un abanico de posibilidades didácticas que se desarrollan en las instituciones educativas en las que laboran los maestros participantes del programa “Maestros y Maestras que Inspiran”. Además, en el uso de diversos modos expresivos para interactuar, aprender y comunicar. Es de resaltar que tienen interés por potenciar los aprendizajes de los estudiantes a partir de propuestas que involucran sus intereses, necesidades y problemáticas del contexto; es decir, son seres dialógicos (Freire, 1973) que tienden puentes entre el conocimiento, las problemáticas y las posibilidades para narrar, expresar, dramatizar, exponer, cantar y representar la realidad a través de diversas formas de comunicación con el fin de transformarla.Primera edición, 202

¡Atención Poli, con la vista en el riesgo! cuentos para seguritos

El contar historias o el storytelling, aparece como una herramienta para autores que no solo buscan el conectar de forma más auténtica con sus lectores; sino que buscan ir más allá al comprender cómo el cerebro procesa esta poderosa forma de comunicación. (Suzuki, W., Feliú-Mójer, M., Hasson, U., Yehuda, R., & Zarate, J. 2018). Esta nueva forma de contar algo, es presentada aquí, en la primera compilación de cuentos como resultado de trabajos de módulos que tratan sobre el cuerpo humano, donde el estudio y la comprensión de la forma cómo funciona nuestro organismo, es uno de los principales objetivos. Además, surge como estrategia pedagógica, que precisamente busca incentivar el desarrollo de la creatividad de los estudiantes dentro de módulos que contienen un importante abordaje de temas y conceptos como base para su desarrollo, módulos que, al incluir un alto contenido teórico, se presentan como retos para que sus temas sean interiorizados por los estudiantes. De este modo, cuando se acude a el uso de la creatividad a través del storytelling, donde se expresan ideas relacionadas con el cuerpo humano, los cuentos realizados por estudiantes aquí presentes logran mostrar cómo emplean dichos conocimientos adquiridos, organizan ideas y crean cuentos que permiten al lector recrease, conociendo diferentes aspectos sobre nuestro cuerpo y a su vez dejándose llevar por la imaginación de los autores

Correction : Chaparro et al. Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study. J. Clin. Med. 2021, 10, 2885

The authors wish to make the following corrections to this paper [...]

Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain : Large-Scale Epidemiological Study

(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD-Crohn's disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)-during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100,000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U; 53% of patients were male and median age was 43 years (interquartile range = 31-56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p < 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, which are greater in CD and in hospitals with high resources, and much higher than previously reported. One third of patients are hospitalized in the first year after diagnosis and a relevant proportion undergo surgery