Test Infrastructure for Address-Event-Representation Communications

Address-Event-Representation (AER) is a communication protocol for transferring spikes between bio-inspired chips. Such systems may consist of a hierarchical structure with several chips that transmit spikes among them in real time, while performing some processing. To develop and test AER based systems it is convenient to have a set of instruments that would allow to: generate AER streams, monitor the output produced by neural chips and modify the spike stream produced by an emitting chip to adapt it to the requirements of the receiving elements. In this paper we present a set of tools that implement these functions developed in the CAVIAR EU project.Unión Europea IST-2001-34124 (CAVIAR)Ministerio de Ciencia y Tecnología TIC-2003-08164-C03-0

Vitamin D Deficiency and COVID-19: A Biological Database Study on Pathways and Gene-Disease Associations

Vitamin D (VD) is a fat-soluble vitamin, and pivotal for maintaining health. Several genetic markers have been related to a deficient VD status; these markers could confer an increased risk to develop osteoporosis and other chronic diseases. A VD deficiency could also be a determinant of a severe COVID-19 disease. This study aimed to interrogate genetic/biological databases on the biological implications of a VD deficiency and its association with diseases, to further explore its link with COVID-19. The genetic variants of both a VD deficiency and COVID-19 were identified in the genome-wide association studies (GWAS) catalog and other sources. We conducted enrichment analyses (considering corrected p-values < 0.05 as statistically significant) of the pathways, and genedisease associations using tools, such as FUMA, REVIGO, DAVID and DisGeNET, and databases, such as the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO). There were 26 and 46 genes associated with a VD deficiency and COVID-19, respectively. However, there were no genes shared between the two. Genes related to a VD deficiency were involved in the metabolism of carbohydrates, retinol, drugs and xenobiotics, and were associated with the metabolic syndrome and related factors (obesity, hypertension and diabetes mellitus), as well as with neoplasms. There were few enriched pathways and disease connections for the COVID-19-related genes, among which some of the aforementioned comorbidities were also present. In conclusion, genetic factors that influence the VD levels in the body are most prominently associated with nutritional and metabolic diseases. A VD deficiency in high-risk populations could be therefore relevant in a severe COVID-19, underlining the need to examine whether a VD supplementation could reduce the severity of this disease.Consejeria de Salud de la Junta de Andalucia - European Regional Development Fund (ERDF-FEDER) PECOVID-0200-202

PCI-AER interface for Neuro-inspired Spiking Systems

Address event representation (AER) is a neuromorphic interchip communication protocol that allows for real-time connectivity between huge number neurons located on different chips. By exploiting high speed digital communication circuits (nano-seconds), synaptic neural connections can be time multiplexed (mili-seconds). When building multi-chip muti-layered AER systems it is absolutely necessary to have a computer interface that allows: (a) to read AER interchip traffic; and (b) inject a sequence of events to the AER structure. This paper presents a PCI to AER interface, that dispatches a sequence of events with timing information. It is able to recovery the possible delays introduced by AER bus. It has been implemented in real time hardware using VHDL and tested in a PCI-AER board, developed by authors, that currently capable to send and receive events at a peak rate of 16 Mev/sec, and a typical rate of 10 Mev/secEuropean Commission IST-2001-34124Ministerio de Ciencia y Tecnología TIC-2003-08164-C03-0

Análisis a Bajo Nivel de Procesadores Superescalares Reales

En esta ponencia-demo se presenta una práctica donde se analiza la influencia en el tiempo de ejecución de algunas optimizaciones sobre el código máquina para procesadores reales (familia Intel Pentium). Se propone el estudio del efecto del emparejamiento de instrucciones y de las dependencias entre registros, la aceleración obtenida con el desenrollado de iteraciones, la comparación entre instrucciones simples (del núcleo RISC) y complejas, etc. Además todo ello se ejecuta desde código ensamblador, midiendo el tiempo y otros eventos directamente sobre los Pentium, gracias a los contadores internos de monitorización del rendimiento (“Performance Monitoring Counters”, PMC) [1] de esta familia de procesadores. El alumno se enfrenta a las dificultades que supone trabajar con el sistema real y a bajo nivel. Se compara con otros métodos existentes y se describen una serie de rutinas para acceder a los contadores dando varios ejemplos de las posibilidades que brindan para el análisis de la estructura superescalar de estos procesadores

Study protocol on Socioeconomic and Geographic Inequalities in CancerIncidence, Mortality and Survival in Spain: Multilevel Population-Base Study:DESOCANES studyKeywords

La incidencia y la mortalidad brindan información sobre la carga de la morbilidad del cáncer y los añoos potenciales de vida perdidos debido al cáncer. Se ha desarrollado el Índice de Privación (IP) como una medida estandarizada para medir la privación socioeconómica en España a nivel de sección censal. Además, se puede combinar la información del IP con variables ecológicas poblacionales y los datos de los Estudios Europeos de Alta Resolución en Cáncer. El objetivo de este estudio es caracterizar las desigualdades socioeconómicas en la incidencia, el exceso de mortalidad, la mortalidad prematura y la supervivencia neta para tres de los cánceres más incidentes (pulmón, colon-recto y mama) en España usando el IP. Este estudio nacional multinivel de base poblacional evaluará el impacto de las desigualdades socioeconómicas. Se usarán el análisis espacial, la modelización multinivel, la supervivencia neta y la evaluación del impacto económico. Los resultados serán útiles para el apoyo a la toma de decisiones y la planificación y la gestión de intervenciones en salud pública destinadas a reducir el impacto de las desigualdades socioeconómicas en el diagnóstico y el pronóstico de los pacientes de cáncer en España.Incidence and mortality provide information on the burden of cancer morbidity and the potential years of life lost due to cancer. The Spanish Deprivation Index (SDI) has been developed as a standardized measure to study socioeconomic deprivation in Spain at the census tract level. In addition, SDI information can becombined with ecological variables at the population level and data from the High-Resolution European Studies in Cancer. The aim of this study is to characterize socioeconomic inequalities in incidence, excess mortality, premature mortality and net survival for three of the most incident cancers (lung, colon-rectum and breast) in Spain using the SDI. This national population-based study will assess the impact of socioeconomic inequalities using a multilevel modelling approach. Spatial analysis, multilevel mode-ling, net survival and economic impact assessment will be used. The results will be useful for supportingdecision-making, planning, and management of public health interventions aimed at reducing the impact of socioeconomic inequalities in the diagnosis and prognosis of cancer patients in Spain

Multiple myeloma and SARS-CoV-2 infection: clinical characteristics and prognostic factors of inpatient mortality

There is limited information on the characteristics, prognostic factors, and outcomes of patients with multiplemyeloma (MM) hospitalized with COVID-19. This retrospective case series investigated 167 patients reported from 73hospitals within the Spanish Myeloma Collaborative Group network in March and April, 2020. Outcomes werecompared with 167 randomly selected, contemporary, age-/sex-matched noncancer patients with COVID-19 admittedat six participating hospitals. Among MM and noncancer patients, median age was 71 years, and 57% of patients weremale; 75 and 77% of patients, respectively, had at least one comorbidity. COVID-19 clinical severity wasmoderate-severe in 77 and 89% of patients and critical in 8 and 4%, respectively. Supplemental oxygen was requiredby 47 and 55% of MM and noncancer patients, respectively, and 21%/9% vs 8%/6% required noninvasive/invasiveventilation. Inpatient mortality was 34 and 23% in MM and noncancer patients, respectively. Among MM patients,inpatient mortality was 41% in males, 42% in patients aged >65 years, 49% in patients with active/progressive MM athospitalization, and 59% in patients with comorbid renal disease at hospitalization, which were independentprognostic factors on adjusted multivariate analysis. This case series demonstrates the increased risk and identifiespredictors of inpatient mortality among MM patients hospitalized with COVID-19

Clínica jurídica de acción social

Memoria ID-0064. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2016-2017

Clínica jurídica de acción social

Memoria ID-025. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2018-2019

Aplicación de la metodología aprendizaje-servicio en la asignatura "Clínica jurídica de acción social" de la Facultad de Derecho

Memoria ID-149. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2019-2020