Monotonicity of a profile of rankings with ties

International Conference, IPMU (17th. 2018. Cádiz

Análisis y propuestas de acción sobre legislación referida al consumo eficiente del agua

El agua es un recurso limitado e indispensable para la supervivencia humana. Una política sustentable, garantiza la preservación de la misma en las fuentes evitando su agotamiento, reduce costos y contaminación, ya que produce una disminución en su consumo y la cantidad de fluentes a tratar. Toda estrategia de ahorro debe abarcar: una legislación acorde a nivel, provincial y nacional, métodos y técnicas de eficiencia, la tecnología disponible, recomendaciones y acciones. Nuestro país se ha caracterizado por carecer de una legislación y políticas referidas al consumo eficiente del agua. En este trabajo se plantea un análisis de la legislación referida al tema. Se comparó la legislación existente en Argentina y en diversos centros urbanos a nivel internacional, con el objetivo de poder determinar las carencias existentes en nuestro medio y definir así conclusiones que lleven a posibles líneas de acción al respecto.Fil: Rodríguez, Viviana L. Universidad Nacional de Cuyo. Facultad de Filosofía y LetrasFil: Lizarraga, Susana B. Universidad Nacional de Cuyo. Facultad de Filosofía y LetrasFil: Araujo, Héctor. Universidad Nacional de Cuyo. Facultad de Filosofía y Letra

Metástasis gingival de adenocarcinoma de colon

La cavidad oral es lugar de asiento de tumores metastásicos, sobre todo con origen en mama y pulmón. La mayoría de los casos afectan por este orden a los huesos mandibular y maxilar, aunque en ocasiones se desarrollan sobre las partes blandas intraorales. Presentamos el caso de un paciente de 62 años diagnosticado de adenocarcinoma de colon sigmoide con metástasis ganglionares y hepáticas, que 6 meses después presenta una lesión vegetante en la encía, interpretada inicialmente como neoplasia primaria de encía, que tras ser biopsiada fue diagnosticada como adenocarcinoma intestinal metastásico. El estudio histológico es obligatorio para diferenciar un adenocarcinoma de los carcinomas de células escamosas, habituales en la zona, y las técnicas inmunohistoquímicas permiten diferenciar entre un tumor metastásico, sea intestinal o de otro origen, y un adenocarcinoma primario originado en glándulas salivares menores de la zona. La presencia de un tumor diseminado con extensión intraoral acarrea un pronóstico ominoso, aunque si se trata de una metástasis única es posible un tratamiento quirúrgico radical con una supervivencia mayor.Metastatic tumors involve the oral cavity, and the most common primary sites are the breast and lung. Most cases affect the mandible and maxilla in that order, although some of them can be located in the soft perioral tissues. We report the case of a 62-year-old male who had been diagnosed with sigmoid adenocarcinoma with nodal and liver metastasis, who presented 6 months later with a gingival polypoid tumor, at first considered as a primary neoplasm of gingiva, that was diagnosed in a biopsy as metastatic intestinal adenocarcinoma. The histological evaluation is essential to separate adenocarcinoma from the commoner in this site squamous cell carcinoma, and the immunohistochemical techniques are useful to distinguish metastatic tumor versus primary adenocarcinoma from the minor salivary glands of the area. The intraoral spread of a disseminated neoplasm is generally a sign of bad prognosis, although a longer survival can be expected if a radical surgical treatment of a solitary metastasis is carried out

Colon adenocarcinoma with metastasis to the gingiva

La cavidad oral es lugar de asiento de tumores metastásicos, sobre todo con origen en mama y pulmón. La mayoría de los casos afectan por este orden a los huesos mandibular y maxilar, aunque en ocasiones se desarrollan sobre las partes blandas intraorales. Presentamos el caso de un paciente de 62 años diagnosticado de adenocarcinoma de colon sigmoide con metástasis ganglionares y hepáticas, que 6 meses después presenta una lesión vegetante en la encía, interpretada inicialmente como neoplasia primaria de encía, que tras ser biopsiada fue diagnosticada como adenocarcinoma intestinal metastásico. El estudio histológico es obligatorio para diferenciar un adenocarcinoma de los carcinomas de células escamosas, habituales en la zona, y las técnicas inmunohistoquímicas permiten diferenciar entre un tumor metastásico, sea intestinal o de otro origen, y un adenocarcinoma primario originado en glándulas salivares menores de la zona. La presencia de un tumor diseminado con extensión intraoral acarrea un pronóstico ominoso, aunque si se trata de una metástasis única es posible un tratamiento quirúrgico radical con una supervivencia mayor

Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6

In order to clarify their physiological functions, we have undertaken a characterization of the three-membered gene families SNZ13 and SNO13. In media lacking vitamin B6, SNZ1 and SNO1 were both required for growth in certain conditions, but neither SNZ2, SNZ3, SNO2 nor SNO3 were required. Copies 2 and 3 of the gene products have, in spite of their extremely close sequence similarity, slightly different functions in the cell. We have also found that copies 2 and 3 are activated by the lack of thiamine and that the Snz proteins physically interact with the thiamine biosynthesis Thi5 protein family. Whereas copy 1 is required for conditions in which B6 is essential for growth, copies 2 and 3 seem more related with B1 biosynthesis during the exponential phase

Risk of serious skin disorders among users of oral antifungals: a population-based study

BACKGROUND: Serious skin disorders have been associated with the use of oral antifungals in a number of case reports and series of cases. However the incidence of these disorders remains unknown. METHODS: We estimated the risk of serious skin disorders in a cohort of users of oral antifungals identified in the general population of the General Practice Research Database in the UK. The cohort included 61,858 patients, 20 to 79 years old, who had received at least one prescription for either oral fluconazole, griseofulvin, itraconazole, ketoconazole, or terbinafine. RESULTS: The background rate of serious cutaneous adverse reactions (the one corresponding to non use of oral antifungals) was 3.9 per 10,000 person-years (95% CI 2.9–5.2). Incidence rates for current use were 15.4 per 10,000 person-years (1.9–55.7) for itraconazole, 11.1 (3.0–28.5) for terbinafine, 10.4 (1.3–37.5) for fluconazole, and 4.6 (0.1–25.8) for griseofulvin. Itraconazole was the antifungal associated with the highest relative risk, 3.9 (0.5–15.0), when compared to the risk among non users, followed by terbinafine and fluconazole, with relative risks of 2.8 (0.7–7.8) and 2.6 (0.3–10.1), respectively. CONCLUSIONS: We conclude that cutaneous disorders associated with the use of oral antifungals in this study were all of mild severity and that the risk associated with the use of oral antifungals was slightly higher than the risk in non-users. The safety profile of terbinafine regarding cutaneous disorders is similar to other antifungals and in the very low range of risks associated with other drugs

Reduced Binding of the Endolysin LysTP712 to Lactococcus lactis ΔftsH Contributes to Phage Resistance

Absence of the membrane protease FtsH in Lactococcus lactis hinders release of the bacteriophage TP712. In this work we have analyzed the mechanism responsible for the non-lytic phenotype of L. lactis ΔftsH after phage infection. The lytic cassette of TP712 contains a putative antiholin–pinholin system and a modular endolysin (LysTP712). Inducible expression of the holin gene demonstrated the presence of a dual start motif which is functional in both wildtype and L. lactis ΔftsH cells. Moreover, simulating holin activity with ionophores accelerated lysis of wildtype cells but not L. lactis ΔftsH cells, suggesting inhibition of the endolysin rather than a role of FtsH in holin activation. However, zymograms revealed the synthesis of an active endolysin in both wildtype and L. lactis ΔftsH TP712 lysogens. A reporter protein was generated by fusing the cell wall binding domain of LysTP712 to the fluorescent mCherry protein. Binding of this reporter protein took place at the septa of both wildtype and L. lactis ΔftsH cells as shown by fluorescence microscopy. Nonetheless, fluorescence spectroscopy demonstrated that mutant cells bound 40% less protein. In conclusion, the non-lytic phenotype of L. lactis ΔftsH is not due to direct action of the FtsH protease on the phage lytic proteins but rather to a putative function of FtsH in modulating the architecture of the L. lactis cell envelope that results in a lower affinity of the phage endolysin to its substrate.This work has been supported by grant BIO2013-46266R (MINECO, Spain). BM, PG, and AR also acknowledge funding by GRUPIN14-139 Plan de Ciencia, Tecnología e Innovación 2013-2017 (Principado de Asturias, Spain) and FEDER EU funds.Peer reviewe