Reservoir Computing Approach to Robust Computation using Unreliable Nanoscale Networks

As we approach the physical limits of CMOS technology, advances in materials science and nanotechnology are making available a variety of unconventional computing substrates that can potentially replace top-down-designed silicon-based computing devices. Inherent stochasticity in the fabrication process and nanometer scale of these substrates inevitably lead to design variations, defects, faults, and noise in the resulting devices. A key challenge is how to harness such devices to perform robust computation. We propose reservoir computing as a solution. In reservoir computing, computation takes place by translating the dynamics of an excited medium, called a reservoir, into a desired output. This approach eliminates the need for external control and redundancy, and the programming is done using a closed-form regression problem on the output, which also allows concurrent programming using a single device. Using a theoretical model, we show that both regular and irregular reservoirs are intrinsically robust to structural noise as they perform computation

The role of structure and complexity on Reservoir Computing quality

We explore the effect of structure and connection complexity on the dynamical behaviour of Reservoir Computers (RC). At present, considerable effort is taken to design and hand-craft physical reservoir computers. Both structure and physical complexity are often pivotal to task performance, however, assessing their overall importance is challenging. Using a recently proposed framework, we evaluate and compare the dynamical freedom (referring to quality) of neural network structures, as an analogy for physical systems. The results quantify how structure affects the range of behaviours exhibited by these networks. It highlights that high quality reached by more complex structures is often also achievable in simpler structures with greater network size. Alternatively, quality is often improved in smaller networks by adding greater connection complexity. This work demonstrates the benefits of using abstract behaviour representation, rather than evaluation through benchmark tasks, to assess the quality of computing substrates, as the latter typically has biases, and often provides little insight into the complete computing quality of physical systems

Prostaglandin E2-bisphosphonate conjugates : potential agents for treatment of osteoporosis.

Conjugates of bisphosphonates (potential bone resorption inhibitors) and prostaglandin E2 (a bone formation enhancer) were prepared and evaluated for their ability to bind to bone and to liberate, enzymatically, free PGE2. The conjugate 3, an amide at C-1 of PGE2 proved to be too stable in vivo while conjugate 6, a thioester, was too labile. Several PGE2, C-15 ester-linked con- jugates (18, 23, 24 and 31) were prepared and conjugate 23 was found to bind effectively to bone in vitro and in vivo and to liberate PGE2 at an acceptable rate. A 4-week study in a rat model of osteoporosis showed that 23 was better tolerated and more effective as a bone growth stimulant than daily maximum tolerated doses of free PGE2

A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency

N-Glycanase 1 (NGLY1) is a cytoplasmic deglycosylating enzyme. Loss-of-function mutations in the NGLY1 gene cause NGLY1 deficiency, which is characterized by developmental delay, seizures, and a lack of sweat and tears. To model the phenotypic variability observed among patients, we crossed a Drosophila model of NGLY1 deficiency onto a panel of genetically diverse strains. The resulting progeny showed a phenotypic spectrum from 0 to 100% lethality. Association analysis on the lethality phenotype, as well as an evolutionary rate covariation analysis, generated lists of modifying genes, providing insight into NGLY1 function and disease. The top association hit was Ncc69 (human NKCC1/2), a conserved ion transporter. Analyses in NGLY1-/- mouse cells demonstrated that NKCC1 has an altered average molecular weight and reduced function. The misregulation of this ion transporter may explain the observed defects in secretory epithelium function in NGLY1 deficiency patients

ASEAN's unchanged melody? The theory and practice of 'non-interference' in Southeast Asia

This is an Author's Accepted Manuscript of an article published as Jones, Lee. (2010). ASEAN's unchanged melody? The theory and practice of 'non-interference' in Southeast Asia. Pacific Review 23:4, 479-502 as published in PACIFIC REVIEW 2010 © Taylor & Francis, available online at: http://www.tandfonline.com/10.1080/09512748.2010.49599

Carbon fiber masculinity: Disability and surfaces of homosociality

In this paper I am concerned with instances in which carbon fiber extends performances of masculinity that are attached to particular kinds of hegemonic male bodies. In examining carbon fiber as a prosthetic form of masculinity, I advance three main arguments. Firstly, carbon fiber can be a site of the supersession of disability that is affected through masculinized technology. Disability can be ‘overcome’ through carbon fiber. Disability is often culturally coded as feminine (Pedersen, 2001; Meeuf, 2009; Garland-Thompson 1997). Building on this cultural construction of disability as feminine, in and as a technology of masculine homosociality (Sedgwick, 1985), carbon fiber reproduced disability as feminine when carbon fiber prosthetic lower legs allowed Oscar Pistorius to compete in the non-disabled Olympic games. Secondly, I argue that carbon fiber can be a homosocial surface; that is, carbon fiber becomes both a surface extension of the self and a third party mediator in homosocial relationships, a surface that facilitates intimacy between men in ways that devalue femininity in both male and female bodies. I examine surfaces as material extensions of subjectivity, and carbon fiber surfaces as vectors of the cultural economies of masculine competition to which I refer. Thirdly, the case of Oscar Pistorius is exemplary of the masculinization of carbon fire, and the associated binding of a psychic attitude of misogyny and power to a form of violent and competitive masculine subjectivity. In this article I explore the affects, economies and surfaces of what I call ‘carbon fiber masculinity’ and discusses Pistorius’ use of carbon fiber, homosociality and misogyny as forms of protest masculinity through which he unconsciously attempted to recuperate his gendered identity from emasculating discourses of disability

Social Cohesion, Structural Holes, and a Tale of Two Measures

EMBARGOED - author can archive pre-print or post-print on any open access repository after 12 months from publication. Publication date is May 2013 so embargoed until May 2014.This is an author’s accepted manuscript (deposited at arXiv arXiv:1211.0719v2 [physics.soc-ph] ), which was subsequently published in Journal of Statistical Physics May 2013, Volume 151, Issue 3-4, pp 745-764. The final publication is available at link.springer.com http://link.springer.com/article/10.1007/s10955-013-0722-