La formulación magistral: adquisición de compètencias mediante ABP y estrategias no presenciales

[cast] La formulación magistral, una de las actividades profesionales más representativas del farmacéutico, consiste en la elaboración, de acuerdo con una prescripción médica, de un medicamento personalizado, adaptado a un paciente concreto, en un compromiso profesional de solucionar un problema de salud específico. La amplia oferta de medicamentos industriales ha reducido considerablemente esta actividad, que a pesar de todo, debe considerarse una herramienta de futuro en sintonía con la tendencia personalizadora actual de la medicina y las necesidades del paciente. Los conocimientos y competencias requeridas para dicha actividad profesional se introducen actualmente en la carrera de Farmacia mediante una asignatura optativa. En el presente trabajo se presenta el planteamiento metodológico diseñado por el Grupo de Innovación Docente de Tecnología Farmacéutica (GIDTF) y el grupo e-Galenica, ambos de la Universidad de Barcelona, para esta asignatura. Dicha metodología esta basada en el Aprendizaje Basado en Problemas (ABP) incluyendo tutorías y prácticas de campo, apoyada en estrategias no presenciales como foro de debate, recursos on-line, cuestionarios y tareas de autoevaluación a través de la plataforma Moodle del Campus Virtual de la UB. Se evalúan asimismo los resultados académicos y las respuestas de los estudiantes a las encuestas realizadas en relación al sistema de impartición de la asignatura. [eng] The pharmaceutical compounding, one of the most representative professional activities of pharmacists, involves the preparation of an individualized medicine tailored to a specific patient in a professional commitment to solve a specific health problem, according to a prescription. The wide range of industrial medicine has significantly reduced this activity, which nevertheless should be considered a tool of the future in line with the current trend of personalizing medicine and patient needs. The knowledge and competences required for this professional activity are introduced to the students of Pharmacy through an optional subject. In this paper we present the ethodological approach developed for this subject by the Teaching Innovation Group of pharmaceutical Technology (GIDTF) and e-Galenica group, both from the University of Barcelona. This methodology is based on Problem-Based Learning (PBL) including tutorials and practices in other centres, supported by out of class strategies as discussion forum, online resources, self-assessment questionnaires and work through the platform Moodle of Virtual Campus UB. The academic performance and student responses to surveys in relation to the didactic methodology are also assessed

Una estrategia para el desarrollo de la capacidad de aprendizaje y responsabilidad

La capacidad de aprendizaje y responsabilidad es una de las competencias transversales que debe adquirir el estudiante de Farmacia. El Grupo de Innovación Docente de Tecnología Farmacéutica (GIDTF) se ha propuesto desarrollarla gradualmente en el ámbito de las prácticas de las asignaturas troncales de Farmacia Galénica distribuidas a lo largo de los estudios de Farmacia. Las actividades se han centrado en la capacidad de adquirir conocimientos, habilidades y actitudes, relacionados con la preparación y control de productos farmacéuticos siguiendo las NCF. El objetivo de este trabajo es presentar la estrategia desarrollada y propuesta para la docencia de dichas asignaturas en el bienio 2011-13

Broad virus inactivation using inorganic micro/nano-particulate materials

Inorganic materials can provide a set of tools to decontaminate solid, liquid or air containing viral particles. The use of disinfectants can be limited or not practical in scenarios where continuous cleaning is not feasible. Physicochemical differences between viruses raise the need for effective formulations for all kind of viruses. In the present work we describe two types of antimicrobial inorganic materials: i) a novel soda-lime glass (G3), and ii) kaolin containing metals nanoparticles (Ag or CuO), as materials to disable virus infectivity. Strong antiviral properties can be observed in G3 glass, and kaolin-containing nanoparticle materials showing a reduction of viral infectivity close to 99%. in the first 10 ​min of contact of vesicular stomatitis virus (VSV). A potent virucidal activity is also present in G3 and kaolin containing Ag or CuO nanoparticles against all kinds of viruses tested, reducing more than 99% the amount of HSV-1, Adenovirus, VSV, Influenza virus and SARS-CoV-2 exposed to them. Virucidal properties could be explained by a direct interaction of materials with viruses as well as inactivation by the presence of virucidal elements in the material lixiviates. Kaolin-based materials guarantee a controlled release of active nanoparticles with antiviral activity. Current coronavirus crisis highlights the need for new strategies to remove viruses from contaminated areas. We propose these low-cost inorganic materials as useful disinfecting antivirals in the actual or future pandemic threats.This research was performed with support from The Spanish National Research Council (CSIC) (Project No 202060E109). M.F. is grateful to the Comunidad Autonoma de Madrid for research project No. 2017-T1/BIO-4992 (“Atracción de Talento” Action) cofunded by Universidad Complutense de Madrid. This publication was also supported by the European Virus Archive GLOBAL (EVA-GLOBAL) project that has received funding from the European Union's Horizon 2020 research and innovation program ​under grant agreement 871029. S. R.-R. was supported by the the FPI fellowship funded by Universidad San Pablo CEU. J.A-H. was supported by the PFIS fellowship co-funded by the FEDER/FSE and the ISCIII

Influencia de las propiedades reológicas en las características sensoriales de cremas solares A/O y O/A

Resumen Se describen los métodos de caracterización de cuatro cremas solares, dos de las cuales (una de tipo A/O y otra O/A) derivan de las otras dos mediante cambios en su composición, con el fin de predecir las posibles variaciones en las propiedades sensoriales táctiles de las mismas a partir de los cambios observados en determinadas propiedades, en particular reológicas. Los resultados muestran que los cambios en las formulaciones originan cremas más viscosas y estables y sin modificación significativa de las propiedades táctiles. Los resultados de la evaluación sensorial se ajustan a las predicciones efectuadas a partir de los del análisis reológico. Palabras clave: Emulsiones, reología, evaluación sensorial, estabilidad, filtros solare

Smoke with Fire: Financial Crises and the Demand for Parliamentary Oversight in the European Union.

The handling of the 2008 financial crisis has reinforced the conviction that the European Union (EU) is undemocratic and that member states are forced to delegate overwhelming power to a supranational technocracy. However, European countries have engaged with this alleged power drift differently, with only a few member states demanding more parliamentary scrutiny of EU institutions. This article develops a political economy explanation for why only some states have enforced mechanisms to monitor the EU more closely. Our theory focuses on the role of the crisis and the impact of fiscal autonomy in countries outside and inside currency arrangements such as the European Economic and Monetary Union (EMU). We argue that, in the aftermath of a severe economic shock, member states outside the EMU possess more monetary and fiscal resources to handle the crisis. These would then demand oversight of EU decision-making if their fiscal sustainability depends on the Union. By contrast, Eurozone states that need policy changes cannot address the crisis independently or initiate reforms to scrutinize the EU. Hence, we argue that during the heated moments of severe economic downturns, parliaments in Eurozone countries discuss supranational supervision rarely. As these legislatures have nevertheless to give in to the popular demand for EU control, they express support for more EU supervision in the infrequent times of debate. We provide evidence for our theory with a cross-national analysis of EU oversight institutions, and a new original dataset of parliamentary debates during the Eurozone crisis. Our findings highlight the political consequences that financial nosedives have across the diverse membership of a supranational organization

Diode-clamped multilevel converters with integrable gate-driver power-supply circuits

International audienceRecent contributions in pulse width modulations (PWM) for multilevel diode-clamped converters enable the use of these converters with passive front-ends, any number of levels, and small dc-link capacitors. Highly compact converters designs based on these topologies can be envisioned. However, the design of the gate-driver power-supply for the multiple controlled semiconductor devices remains an important issue to be addressed. This paper focuses on the design of such circuits and the analysis of the resulting multilevel converter performance. A simple circuit connected across each power switch and monolithically integrable within it is selected. These circuits lead to simple, compact, and efficient converter designs. The main issues arising from the operation of the multilevel converter with such circuits are analyzed, and both hardware and software solutions are proposed. In particular, a new PWM strategy is presented. Experimental results are provided verifying the good performance of all proposed solutions

Synchronous Power Control of Grid-Connected Power Converters under Asymmetrical Grid Fault

Control of grid-connected power converters is continuously developing to meet the grid codes, according to which the generation units should keep connected to the grid and further provide ancillary services, such as voltage and frequency support, negative sequence current injection, inertia emulation, etc. A virtual admittance controller is proposed in this paper for the objective of voltage support under asymmetrical grid faults. By using independent and selective admittances for positive and negative sequence current injection, the unbalanced voltage can be significantly compensated during asymmetrical faults. The controller is based on the generic control framework of the synchronous power controller (SPC), which is able to control a power converter with emulated and improved synchronous generator characteristics. Simulation and experimental results based on two paralleled 100 kW grid-connected power converters demonstrate the controller to be effective in supporting unbalanced voltage sags