La cooperación española contra la trata con fines de explotación sexual. El caso de Nigeria

El presente escrito está dirigido a analizar la aplicación de las normativas y directrices tanto nacionales como internacionales en los procesos de detección, identificación, protección y asistencia a mujeres víctimas de trata de seres humanos con fines de explotación sexual. El objetivo que se persigue con este estudio es el de valorar si las ordenanzas se ajustan a las especificidades de un perfil concreto, el de mujeres provenientes de Nigeria. Poe ese motivo se ha analizado la incidencia de la trata en nuestro país, se ha hecho un breve análisis del contexto origen y del perfil extrayendo los aspectos más relevantes; se ha revisado la legislación vigente con aplicación en España; y posteriormente se ha valorado su puesta en práctica en los procedimientos considerados y en el marco del supuesto mencionado, teniendo en consideración las aportaciones de organismos internacionales expertos en esta materia. En el transcurso del análisis se han tenido especialmente en consideración las estrategias de cooperación y la perspectiva de derechos humanos

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele