Effect of cytokine growth factors on the prevention of acute wound failure

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73237/1/j.1067-1927.2004.012109.x.pd

Use of the wound healing trajectory as an outcome determinant for acute wound healing

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72454/1/j.1524-475x.2000.00511.x.pd

ISCEV guidelines for calibration and verification of stimuli and recording instruments (2023 update)

This document developed by the International Society for Clinical Electrophysiology of Vision (ISCEV) provides guidance for calibration and verification of stimulus and recording systems specific to clinical electrophysiology of vision. This guideline provides additional information for those using ISCEV Standards and Extended protocols and supersedes earlier Guidelines. The ISCEV guidelines for calibration and verification of stimuli and recording instruments (2023 update) were approved by the ISCEV Board of Directors 01, March 2023

Foundations and interpretations of the pulsed-Townsend experiment

The pulsed-Townsend (PT) experiment is a well known swarm technique used to measure transport properties from a current in an external circuit, the analysis of which is based on the governing equation of continuity. In this paper, the Brambring representation (1964 Z. Phys. 179 532) of the equation of continuity often used to analyse the PT experiment, is shown to be fundamentally flawed when non-conservative processes are operative. The Brambring representation of the continuity equation is not derivable from Boltzmann's equation and consequently transport properties defined within the framework are not clearly representable in terms of the phase-space distribution function. We present a re-analysis of the PT experiment in terms of the standard diffusion equation which has firm kinetic theory foundations, furnishing an expression for the current measured by the PT experiment in terms of the universal bulk transport coefficients (net ionisation rate, bulk drift velocity and bulk longitudinal diffusion coefficient). Furthermore, a relationship between the transport properties previously extracted from the PT experiment using the Brambring representation, and the universal bulk transport coefficients is presented. The validity of the relationship is tested for two gases Ar and SF6, highlighting also estimates of the differences

FcγRIII and FcγRIV are indispensable for acute glomerular inflammation induced by switch variant monoclonal antibodies

The relative ability of IgG subclasses to cause acute inflammation, and the roles of specific effector mechanisms in this process is not clear. We explored this in an in vivo model of glomerular inflammation in the mouse. TNP was planted on the glomerular basement membrane after conjugation to nephrotoxic antibody. The relative nephritogenicity of anti-TNP switch-variant monoclonal antibodies was then explored and shown to be IgG2a>IgG2b, with no disease caused by IgG1. Using knockout mice, we showed that FcγRIII was necessary for both neutrophil influx and glomerular damage induced by IgG2a and IgG2b. Surprisingly IgG1 did not cause disease although it binds to FcγRIII. Using blocking antibodies, we showed that this was explained by an additional requirement for FcγRIV which does not bind to IgG1. IgG2a or IgG2b induced neutrophil influx was not affected by deficiency of either FcγRI or C3. Bone marrow chimeras were constructed to test the effect of combined deficiency of FcγRI and C3, and there was no effect on IgG2a or IgG2b mediated neutrophil influx. However, IgG2b-induced albuminuria and thrombosis was reduced in C3 deficient mice, showing an additional role for complement in IgG2b-mediated glomerular damage. The results show that IgG2a and IgG2b are the pathogenic subclasses in acute neutrophil-mediated glomerular inflammation, with an indispensible role for both FcγRIII and FcγRIV. In addition complement contributes to IgG2b induced glomerular injury

Relativistic theory of elastic deformable astronomical bodies: perturbation equations in rotating spherical coordinates and junction conditions

In this paper, the dynamical equations and junction conditions at the interface between adjacent layers of different elastic properties for an elastic deformable astronomical body in the first post-Newtonian approximation of Einstein theory of gravity are discussed in both rotating Cartesian coordinates and rotating spherical coordinates. The unperturbed rotating body (the ground state) is described as uniformly rotating, stationary and axisymmetric configuration in an asymptotically flat space-time manifold. Deviations from the equilibrium configuration are described by means of a displacement field. In terms of the formalism of relativistic celestial mechanics developed by Damour, Soffel and Xu, and the framework established by Carter and Quintana the post Newtonian equations of the displacement field and the symmetric trace-free shear tensor are obtained. Corresponding post-Newtonian junction conditions at interfaces also the outer surface boundary conditions are presented. The PN junction condition is an extension of Wahr's one which is a Newtonian junction conditions without rotating.Comment: Revtex4, 14 page

Flinders Island spotted fever rickettsioses caused by "marmionii" strain of rickettsia honei, Eastern Australia

Australia has 4 rickettsial diseases: murine typhus, Queensland tick typhus, Flinders Island spotted fever, and scrub typhus. We describe 7 cases of a rickettsiosis with an acute onset and symptoms of fever (100%), headache (71%), arthralgia (43%), myalgia (43%), cough (43%), maculopapular/petechial rash (43%), nausea (29%), pharyngitis (29%), lymphadenopathy (29%), and eschar (29%). Cases were most prevalent in autumn and from eastern Australia, including Queensland, Tasmania, and South Australia. One patient had a history of tick bite (Haemaphysalis novaeguineae). An isolate shared 99.2%, 99.8%, 99.8%, 99.9%, and 100% homology with the 17 kDa, ompA, gltA, 16S rRNA, and Sca4 genes, respectively, of Rickettsia honei. This Australian rickettsiosis has similar symptoms to Flinders Island spotted fever, and the strain is genetically related to R. honei. It has been designated the "marmionii" strain of R. honei, in honor of Australian physician and scientist Barrie Marmion

Validating the simulation of beam-ion charge exchange in MAST Upgrade

Simulation of the impact of charge-exchange (CX) reactions on beam ions in the Mega Amp Spherical Tokamak (MAST) Upgrade was compared to measurements carried out with a fission chamber (neutron fluxes) and a fast ion deuterium-alpha (FIDA) diagnostic. A simple model was developed to reconstruct the outer-midplane neutral density based on measurements of deuterium-alpha emission from edge neutrals, and on Thomson scattering measurements of electron density and temperature. The main computational tools used were the ASCOT orbit-following code and the FIDASIM code for producing synthetic FIDA signals. The neutral density reconstruction agrees qualitatively with SOLPS-ITER modelling and yields a synthetic passive FIDA signal that is consistent with measurement. When CX losses of beam ions are accounted for, predicted neutron emission rates are quantitatively more consistent with measurement. It was necessary to account for CX losses of beam ions in simulations to reproduce the measured passive FIDA signal quantitatively and qualitatively. The results suggest that the neutral density reconstruction is a good approximation, that CX with edge neutrals causes significant beam-ion losses in MAST Upgrade, typically 20% of beam power, and that the ASCOT fast-ion CX model can be used to accurately predict the redistribution and loss of beam ions due to CX