Toxicity studies of Coolanol 15 Final report, Jan. - Sep. 1965

Toxicity studies of synthetic fluid coolant for manned spacecraft heat transfer system

The Orbital Light Curve of Aquila X-1

We obtained R- and I-band CCD photometry of the soft X-ray transient/neutron- star binary Aql X-1 in 1998 June while it was at quiescence. We find that its light curve is dominated by ellipsoidal variations, although the ellipsoidal variations are severely distorted and have unequal maxima. After we correct for the contaminating flux from a field star located only 0.46" away, the peak-to-peak amplitude of the modulation is ~0.25 mag in the R band, which requires the orbital inclination to be greater than 36 degrees. The orbital period we measure is consistent with the 18.95 h period measured by Chevalier & Ilovaisky (1998). During its outbursts the light curve of Aql X-1 becomes single humped. The outburst light curve observed by Garcia et al. (1999) agrees in phase with our quiescent light curve. We show that the single humped variation is caused by a ``reflection effect,'' that is, by heating of the side of the secondary star facing towards the neutron star.Comment: 18 manuscript pages, 7 figures; accepted by A

Investigation of microwave transitions and nonlinear magneto-optical rotation in anti-relaxation-coated cells

Using laser optical pumping, widths and frequency shifts are determined for microwave transitions between ground-state hyperfine components of $^{85}$Rb and $^{87}$Rb atoms contained in vapor cells with alkane anti-relaxation coatings. The results are compared with data on Zeeman relaxation obtained in nonlinear magneto-optical rotation (NMOR) experiments, a comparison important for quantitative understanding of spin-relaxation mechanisms in coated cells. By comparing cells manufactured over a forty-year period we demonstrate the long-term stability of coated cells, an important property for atomic clocks and magnetometers

Multiwavelength Observations of Swift J1753.5-0127

We present contemporaneous X-ray, ultraviolet, optical and near-infrared observations of the black hole binary system, Swift J1753.5-0127, acquired in 2012 October. The UV observations, obtained with the Cosmic Origins Spectrograph on the Hubble Space Telescope, are the first UV spectra of this system. The dereddened UV spectrum is characterized by a smooth, blue continuum and broad emission lines of CIV and HeII. The system was stable in the UV to <10% during our observations. We estimated the interstellar reddening by fitting the 2175 A absorption feature and fit the interstellar absorption profile of Ly$\alpha$ to directly measure the neutral hydrogen column density along the line of sight. By comparing the UV continuum flux to steady-state thin accretion disk models, we determined upper limits on the distance to the system as a function of black hole mass. The continuum is well fit with disk models dominated by viscous heating rather than irradiation. The broadband spectral energy distribution shows the system has declined at all wavelengths since previous broadband observations in 2005 and 2007. If we assume that the UV emission is dominated by the accretion disk the inner radius of the disk must be truncated at radii above the ISCO to be consistent with the X-ray flux, requiring significant mass loss from outflows and/or energy loss via advection into the black hole to maintain energy balance.Comment: To appear in the Ap

Shearing Interferometer for Quantifying the Coherence of Hard X-Ray Beams

We report a quantitative measurement of the full transverse coherence function of the 14.4 keV x-ray radiation produced by an undulator at the Swiss Light Source. An x-ray grating interferometer consisting of a beam splitter phase grating and an analyzer amplitude grating has been used to measure the degree of coherence as a function of the beam separation out to 30 m. Importantly, the technique provides a model-free and spatially resolved measurement of the complex coherence function and is not restricted to high resolution detectors and small fields of view. The spatial characterization of the wave front has important applications in discovering localized defects in beam line optics

Peeling properties of lightlike signals in General Relativity

The peeling properties of a lightlike signal propagating through a general Bondi-Sachs vacuum spacetime and leaving behind another Bondi-Sachs vacuum space-time are studied. We demonstrate that in general the peeling behavior is the conventional one which is associated with a radiating isolated system and that it becomes unconventional if the asymptotically flat space-times on either side of the history of the light-like signal tend to flatness at future null infinity faster than the general Bondi-Sachs space-time. This latter situation occurs if, for example, the space-times in question are static Bondi-Sachs space- times.Comment: 14 pages, LaTeX2

Identifying specific prefrontal neurons that contribute to autism-associated abnormalities in physiology and social behavior.

Functional imaging and gene expression studies both implicate the medial prefrontal cortex (mPFC), particularly deep-layer projection neurons, as a potential locus for autism pathology. Here, we explored how specific deep-layer prefrontal neurons contribute to abnormal physiology and behavior in mouse models of autism. First, we find that across three etiologically distinct models-in utero valproic acid (VPA) exposure, CNTNAP2 knockout and FMR1 knockout-layer 5 subcortically projecting (SC) neurons consistently exhibit reduced input resistance and action potential firing. To explore how altered SC neuron physiology might impact behavior, we took advantage of the fact that in deep layers of the mPFC, dopamine D2 receptors (D2Rs) are mainly expressed by SC neurons, and used D2-Cre mice to label D2R+ neurons for calcium imaging or optogenetics. We found that social exploration preferentially recruits mPFC D2R+ cells, but that this recruitment is attenuated in VPA-exposed mice. Stimulating mPFC D2R+ neurons disrupts normal social interaction. Conversely, inhibiting these cells enhances social behavior in VPA-exposed mice. Importantly, this effect was not reproduced by nonspecifically inhibiting mPFC neurons in VPA-exposed mice, or by inhibiting D2R+ neurons in wild-type mice. These findings suggest that multiple forms of autism may alter the physiology of specific deep-layer prefrontal neurons that project to subcortical targets. Furthermore, a highly overlapping population-prefrontal D2R+ neurons-plays an important role in both normal and abnormal social behavior, such that targeting these cells can elicit potentially therapeutic effects