527 research outputs found
Jagged Edges of the Glass Ceiling
Although many aspiring, young women might believe the glass ceiling was shattered a decade ago, they still need to understand how that glass ceiling impacted an older generation of women in educational leadership. they also must be aware that some segments of the glass ceiling might still exist. This article provides a historical overview of the external barriers faced by women in educational leadership and presents mentoring recommendations to both generations
High energy exchange: proteins that make or break phosphoramidate bonds
AbstractSeveral proteins that catalyze phosphoryl transfer reactions involving phosphohistidine residues have recently been structurally characterized. The architecture of two histidine kinases defines a new protein kinase fold. The diverse folds of several phosphotransfer proteins appear to be designed to foster protein–protein interactions between transfer partners
Passages: A case study of an Iowa female secondary principal
The purpose of this exploratory case study was to identify and describe one female Iowa secondary principal\u27s career path to the principalship in an Iowa public high school. Several factors were considered in the selection of the participant including: demographics, administrative experience, and her willingness to spend time in the interview process. To provide semi-structure to the interviews and in turn suggest the conceptual frame for analyzing the data, the following questions were formulated:
1. What were the experiences which served as perceived barriers in the career path to the high school principalship for one Iowa female high school principal?
2. How does one Iowa female high school principal view her role, strengths, and limitations based on her experiences as a high school principal?
3. How does one Iowa female high school principal describe her leadership style?
4. How do those who work with one Iowa female high school principal describe her leadership style?
The combined experiences and leadership style from one female educational administrator\u27s own perspective emerged as data was gathered, analyzed, and organized. On-site observations, interviews with the participant\u27s associates, and archival documents clarified meaning to provide credibility and confirmability. The method chosen in the case study for presentation of data was a descriptive narrative.
The study provided a rich description of one Iowa female high school principal\u27s career path. The documented singular voice of one Iowa female high school principal adds to the understanding of the unique role of female high school principals in a basically rural state where female high school principals are in a minority. The study provides a thick description of a career passage for females in Iowa who aspire to the principalship as well as practicing female high school principals. Furthermore, the study provides a new term for describing a leadership trait earlier identified as strong and soft traits. The term, stroft, suggests a new way of thinking of a leadership trait defined as strong and soft but conceptually understood as a blend of those characteristics that equals stroft
Hydro-PE: gridded datasets of historical and future Penman-Monteith potential evaporation for the United Kingdom
We present two new potential evaporation datasets for the United Kingdom: a historical dataset, Hydro-PE HadUKGrid, which is derived from the HadUK-Grid gridded observed meteorology (1969–2021); and a future dataset, Hydro-PE UKCP18 RCM, which is derived from UKCP18 regional climate projections (1980–2080). Both datasets are suitable for hydrological modelling, and provide Penman-Monteith potential evapotranspiration parameterised for short grass, with and without a correction for interception on days with rainfall. The potential evapotranspiration calculations have been formulated to closely follow the methodology of the existing Meteorological Office Rainfall and Evaporation Calculation System (MORECS) potential evapotranspiration, which has historically been widely used by hydrological modellers in the United Kingdom. The two datasets have been created using the same methodology, to allow seamless modelling from past to future. Hydro-PE HadUK-Grid shows good agreement with MORECS in much of the United Kingdom, although Hydro-PE HadUK Grid is higher in the mountainous regions of Scotland and Wales. This is due to differences in the underlying meteorology, in particular the wind speed, which are themselves due to the different spatial scales of the data. Hydro-PE HadUK-Grid can be downloaded from https://doi.org/10.5285/9275ab7e-6e93-42bc-8e72-59c98d409deb (Brown et al., 2022) and Hydro-PE UKCP18 RCM can be downloaded from https://doi.org/10.5285/eb5d9dc4-13bb-44c7-9bf8-c5980fcf52a4 (Robinson et al., 2021).</p
Sub-concussive Hit Characteristics Predict Deviant Brain Metabolism in Football Athletes
Magnetic resonance spectroscopy and helmet telemetry were used to monitor the neural metabolic response to repetitive head collisions in 25 high school American football athletes. Specific hit characteristics were determined highly predictive of metabolic alterations, suggesting that sub-concussive blows can produce biochemical changes and potentially lead to neurological problems
Identification of two origins of replication in the single chromosome of the archaeon Sulfolobus solfataricus. Cell 116:25–38
East Midlands Research into Ageing Network (EMRAN) Discussion Paper Series
Academic geriatric medicine in Leicester
.
There has never been a better time to consider joining us. We have recently appointed a
Professor in Geriatric Medicine, alongside Tom Robinson in stroke and Victoria Haunton,
who has just joined as a Senior Lecturer in Geriatric Medicine. We have fantastic
opportunities to support students in their academic pursuits through a well-established
intercalated BSc programme, and routes on through such as ACF posts, and a successful
track-record in delivering higher degrees leading to ACL post. We collaborate strongly
with Health Sciences, including academic primary care. See below for more detail on our
existing academic set-up.
Leicester Academy for the Study of Ageing
We are also collaborating on a grander scale, through a joint academic venture focusing
on ageing, the ‘Leicester Academy for the Study of Ageing’ (LASA), which involves the
local health service providers (acute and community), De Montfort University; University
of Leicester; Leicester City Council; Leicestershire County Council and Leicester Age UK.
Professors Jayne Brown and Simon Conroy jointly Chair LASA and have recently been
joined by two further Chairs, Professors Kay de Vries and Bertha Ochieng. Karen
Harrison Dening has also recently been appointed an Honorary Chair.
LASA aims to improve outcomes for older people and those that care for them that takes
a person-centred, whole system perspective. Our research will take a global perspective,
but will seek to maximise benefits for the people of Leicester, Leicestershire and Rutland,
including building capacity. We are undertaking applied, translational, interdisciplinary
research, focused on older people, which will deliver research outcomes that address
domains from: physical/medical; functional ability, cognitive/psychological; social or
environmental factors. LASA also seeks to support commissioners and providers alike for
advice on how to improve care for older people, whether by research, education or
service delivery. Examples of recent research projects include: ‘Local History Café’
project specifically undertaking an evaluation on loneliness and social isolation; ‘Better
Visits’ project focused on improving visiting for family members of people with dementia
resident in care homes; and a study on health issues for older LGBT people in Leicester.
Clinical Geriatric Medicine in Leicester
We have developed a service which recognises the complexity of managing frail older
people at the interface (acute care, emergency care and links with community services).
There are presently 17 consultant geriatricians supported by existing multidisciplinary
teams, including the largest complement of Advance Nurse Practitioners in the country.
Together we deliver Comprehensive Geriatric Assessment to frail older people with
urgent care needs in acute and community settings.
The acute and emergency frailty units – Leicester Royal Infirmary
This development aims at delivering Comprehensive Geriatric Assessment to frail older
people in the acute setting. Patients are screened for frailty in the Emergency
Department and then undergo a multidisciplinary assessment including a consultant
geriatrician, before being triaged to the most appropriate setting. This might include
admission to in-patient care in the acute or community setting, intermediate care
(residential or home based), or occasionally other specialist care (e.g. cardiorespiratory).
Our new emergency department is the county’s first frail friendly build and includes
fantastic facilities aimed at promoting early recovering and reducing the risk of hospital
associated harms.
There is also a daily liaison service jointly run with the psychogeriatricians (FOPAL); we
have been examining geriatric outreach to oncology and surgery as part of an NIHR
funded study.
We are home to the Acute Frailty Network, and those interested in service developments
at the national scale would be welcome to get involved.
Orthogeriatrics
There are now dedicated hip fracture wards and joint care with anaesthetists,
orthopaedic surgeons and geriatricians. There are also consultants in metabolic bone
disease that run clinics.
Community work
Community work will consist of reviewing patients in clinic who have been triaged to
return to the community setting following an acute assessment described above.
Additionally, primary care colleagues refer to outpatients for sub-acute reviews. You will
work closely with local GPs with support from consultants to deliver post-acute, subacute,
intermediate and rehabilitation care services.
Stroke Medicine
24/7 thrombolysis and TIA services. The latter is considered one of the best in the UK
and along with the high standard of vascular surgery locally means one of the best
performances regarding carotid intervention
FYN is overexpressed in human prostate cancer
To test the hypothesis that FYN , a member of the SRC family of kinases (SFKs), is up-regulated in prostate cancer, as FYN is functionally distinct from other SFKs, and interacts with FAK and paxillin (PXN), regulators of cell morphology and motility. MATERIALS AND METHODS Through data-mining in Oncomine ( http://www.oncomine.org ), cell-line profiling with immunoblotting, quantitative reverse transcription and polymerase chain reaction (RT-PCR) and immunohistochemical analysis, we described FYN expression in prostate cancer. The analysis included 32 cases of prostate cancer, nine of prostatic intraepithelial neoplasia (PIN) and 19 normal prostates. Samples were scored for the percentage of stained glands and intensity of staining (from 0 to 3). Each sample was assigned a composite score generated by multiplying percentage and intensity. RESULTS Data-mining showed an eight times greater FYN expression in prostate cancer than in normal tissue; this was specific to FYN and not present for other SFKs. Expression of FYN in prostate cancer cell lines (LNCaP, 22Rv1, PC3, DuPro) was detected using quantitative RT-PCR and immunoblotting. Expression of FYN and its signalling partners FAK and PXN was detected in human tissue. Comparing normal with cancer samples, there was a 2.1-fold increase in median composite score for FYN ( P  < 0.001) 1.7-fold increase in FAK ( P  < 0.001), and a doubling in PXN ( P  < 0.05). There was a 1.7-fold increase in FYN ( P  < 0.05) and a 1.6-fold increase in FAK ( P  < 0.01) in cancer compared with PIN. CONCLUSIONS These studies support the hypothesis that FYN and its related signalling partners are up-regulated in prostate cancer, and support further investigation into the role of the FYN as a therapeutic target.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/71987/1/j.1464-410X.2008.08009.x.pd
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