Orographic Precipitation Over the Island of Oahu.

Ph.D. Thesis. University of Hawaiʻi at Mānoa 2018

Altered sleep and EEG power in the P301S Tau transgenic mouse model

OBJECTIVE: Sleep disturbances are prevalent in human tauopathies yet despite the importance of sleep, little is known about its relationship with tau pathology. Here, we investigate this interaction by analyzing sleep and tau pathology throughout tauopathy disease progression in P301S human tau transgenic mice. METHODS: P301S and wild‐type mice were analyzed by electroencephalography (EEG)/electromyography at 3, 6, 9, and 11 months of age for sleep/wake time, EEG power, and homeostatic response. Cortical volume and tau pathology was also assessed by anti‐phospho‐tau AT8 staining. RESULTS: P301S tau mice had significantly decreased rapid eye movement (REM) sleep at 9 months of age and decreased REM and non‐REM (NREM) sleep as well as increased wakefulness at 11 months. Sleep loss was characterized by fewer wake, REM, and NREM bouts, increased wake bout duration, and decreased sleep bout duration. Decreased REM and NREM sleep was associated with increased brainstem tau pathology in the sublaterodorsal area and parafacial zone, respectively. P301S mice also showed increased EEG power at 6 and 9 months of age and decreased power at 11 months. Decreased EEG power was associated with decreased cortical volume. Despite sleep disturbances, P301S mice maintained homeostatic response to sleep deprivation. INTERPRETATION: Our results indicate that tau pathology is associated with sleep disturbances that worsen with age and these changes may be related to tau pathology in brainstem sleep regulating regions as well as neurodegeneration. Tau‐induced sleep changes could affect disease progression and be a marker for therapeutic efficacy in this and other tauopathy models

Global Spinors and Orientable Five-Branes

Fermion fields on an M-theory five-brane carry a representation of the double cover of the structure group of the normal bundle. It is shown that, on an arbitrary oriented Lorentzian six-manifold, there is always an Sp(2) twist that allows such spinors to be defined globally. The vanishing of the arising potential obstructions does not depend on spin structure in the bulk, nor does the six-manifold need to be spin or spin-C. Lifting the tangent bundle to such a generalised spin bundle requires picking a generalised spin structure in terms of certain elements in the integral and modulo-two cohomology of the five-brane world-volume in degrees four and five, respectively.Comment: 18 pages, LaTeX; v2: version to appear in JHE

Cold preservation of the human colon and ileum with University of Wisconsin solution

The inclusion of the colon in the intestinal graft resulted in worsening patient and graft outcome and increased the incidence of infection and rejection. In this study, we examine the role of ischemia on the barrier function of the epithelium during cold ischemia. Samples were collected from 15 harvested and transplanted human donor grafts (colon, 10; ileum, 6), which were immersed in University of Wisconsin (UW) solution. Ischemia (6, 12, 24, and 45 h) and reoxygenation were performed to evaluate the mucosal electrical status using the Ussing chamber technique. The functions of enterocytes and crypt cells were tested by glucose and theophylline challenge. Modified Park's classification was applied to evaluate the severity of mucosal damage under light microscopy. The colon had higher levels of baseline potential difference, short-circuit current, and resistance than the ileum during 6-48 h of ischemia. Colonic epithelial cells responded well to theophylline stimulation at 24 h of ischemia, while there was no ileal response. The colonic mucosa was histopathologically well preserved in UW solution for 48 h, and mucosal damage induced by reoxygenation was less than in the ileum. In conclusion, electrophysiologically and histopathologically, the colon is less susceptible to cold preservation damage than the ileum during storage with UW solution

American Indians and COVID-19: Morbidity and Mortality Disparities among Indigenous Populations in the Rural South

Background The COVID-19 pandemic has highlighted health inequities among indigenous populations, with those in rural settings facing compounded barriers.Purpose To investigate morbidity and mortality experiences among hospitalized, COVID-19+ American Indian adults from rural and urban settings.Methods The described cross-sectional study used retrospective discharge data from the University of Mississippi Medical Center and Hennepin County Medical Center. Adults (≥ age 18) admitted from January 1, 2020 to August 8, 2021with a COVID-19 diagnosis and known race were included.Results A total of 3,659 inpatients met inclusion criteria. Among adults hospitalized with COVID-19 at the University of Mississippi Medical Center, American Indians (n=73) had the highest mean comorbidity risk score (11.2, SD 8.1) and unadjusted mortality rate (42%) among all races. Among adults hospitalized with COVID-19 at Hennepin County Medical Center, American Indians (n=62) had the second lowest comorbidity risk score (6.1, SD 10.7) and the lowest unadjusted mortality rate (6%). American Indian mortality disparities persisted after controlling for age, sex, and comorbidity risk.Conclusion Hospitalized American Indians from predominantly rural settings experienced significant morbidity and COVID-19 mortality disparities when compared to native persons in predominantly urban environments, or Blacks and Whites in either setting. Compounded disparities faced by rural, indigenous populations must be addressed

Angoff anchor statements: setting a flawed gold standard?

http://www.mededpublish.org/manuscripts/120

Pastoral lease assessment using geospatial analysis

Seven remote sensing based Vegetation Indices (NDSVI, STVI-3, NDVI, Green + Red, Red, Land Monitor and STVI-1) were tested for their potential to discriminate between “poor” and “good” range condition assessments in Western Australia’s pastoral rangelands. Indices were computed using the Australian Greenhouse Office National Carbon Accounting System (AGO NCAS) repository of calibrated Landsat TM/ETM+ mosaics. Discrimination potential was assessed at two levels of stratification – station level (identical to the stratification used to collect the traverse data), and functional group level (an aggregation of similar land systems)

Development and evaluation of a continuous microwave processing system for hydrocarbon removal from solids

A continuous conveyor-belt processing concept using microwave heating was developed and evaluated. Four hydrocarbon-contaminated soils were used as model feedstocks, and the degree of organic removal was assessed against the power and energy input to the process. The findings of this study at scale (150kg/h) are in direct agreement with data obtained in batch laboratory scale experiments, and show that microwave heating processes are fundamentally scalable. It is shown that there is a trade-off between the efficiency of organic removal and the power distribution, and applying the power in a single stage was found to be 20-30% more energy efficient but the overall degree of organic removal is limited to 60%. 75% removal was possible using two processing steps in series, but the organic removal is ultimately limited by the amount of power that can be safely and reliably delivered to the process material. The concept presented in this work is feasible when 75% organic removal is sufficient, and could form a viable industrial-scale process based on the findings of this study