Probing Spatial Variation Of The Fine-Structure Constant Using The CMB

The fine-structure constant, α, controls the strength of the electromagnetic interaction. There are extensions of the standard model in which α is dynamical on cosmological length and time scales. The physics of the cosmic microwave background (CMB) depends on the value of α. The effects of spatial variation in α on the CMB are similar to those produced by weak lensing: smoothing of the power spectrum, and generation of non-Gaussian features. These would induce a bias to estimates of the weak-lensing potential power spectrum of the CMB. Using this effect, Planck measurements of the temperature and polarization power spectrum, as well as estimates of CMB lensing, are used to place limits (95% C.L.) on the amplitude of a scale-invariant angular power spectrum of α fluctuations relative to the mean value (CαL=AαSI/[L(L+1)]) of AαSI≤1.6×10−5. The limits depend on the assumed shape of the α-fluctuation power spectrum. For example, for a white-noise angular power spectrum (CαL=AαWN), the limit is AαWN≤2.3×10−8. It is found that the response of the CMB to α fluctuations depends on a separate-universe approximation, such that theoretical predictions are only reliable for α multipoles with L≲100. An optimal trispectrum estimator can be constructed and it is found that it is only marginally more sensitive than lensing techniques for Planck but significantly more sensitive when considering the next generation of experiments. For a future CMB experiment with cosmic-variance limited polarization sensitivity (e.g., CMB-S4), the optimal estimator could detect α fluctuations with AαSI\u3e1.9×10−6 and AαWN\u3e1.4×10−9

Attempted DNA extraction from a Rancho La Brea Columbian mammoth (Mammuthus columbi): prospects for ancient DNA from asphalt deposits.

Fossil-bearing asphalt deposits are an understudied and potentially significant source of ancient DNA. Previous attempts to extract DNA from skeletons preserved at the Rancho La Brea tar pits in Los Angeles, California, have proven unsuccessful, but it is unclear whether this is due to a lack of endogenous DNA, or if the problem is caused by asphalt-mediated inhibition. In an attempt to test these hypotheses, a recently recovered Columbian mammoth (Mammuthus columbi) skeleton with an unusual pattern of asphalt impregnation was studied. Ultimately, none of the bone samples tested successfully amplified M. columbi DNA. Our work suggests that reagents typically used to remove asphalt from ancient samples also inhibit DNA extraction. Ultimately, we conclude that the probability of recovering ancient DNA from fossils in asphalt deposits is strongly (perhaps fatally) hindered by the organic compounds that permeate the bones and that at the Rancho La Brea tar pits, environmental conditions might not have been ideal for the general preservation of genetic material

Lunar Network Tracking Architecture for Lunar Flight

A trade study was conducted with the objective of comparing and contrasting the radiometric navigation performance provided by various architectures of lunar-based navigations assets. Architectures considered consist of a compliment of two beacons located on the lunar surface, and two orbiting beacons that provide range and range-rate measurements to the user. Configurations of these assets include both coplanar and linked constellations of frozen elliptic orbiters and halo orbiters. Each architecture was studied during the lunar-approach, lunar-orbit, and landing phases of a South Pole lunar sortie mission. Navigation filter performance was evaluated on the basis of filter convergence latency, and the steady state uncertainty in the navigation solution. The sensitivity of the filter solution to Earth-based tracking augmentation and availability of range measurements was also studied. Filter performance was examined during the build up of the lunar-based navigation system by exploring different combinations of orbiting and surface-based assets

Public policy to promote entrepreneurship: a call to arms

We debate the motivation for and effectiveness of public policies to encourage individuals to become entrepreneurs. Reviewing established evidence we find that most Western world policies do not greatly reduce or solve any market failures but instead waste taxpayers’ money, encourage those already intent on becoming entrepreneurs, and mostly generate one-employee businesses with low-growth intentions and a lack of interest in innovating. Most policy initiatives that would have the effect of promoting valuable entrepreneurship would not be recognizable as such, because they would primarily address other market failures: A central-payer health care would remove healthcare-related distortions affecting employment choices; greater STEM education would produce more engineers of which some start valuable new firms; and labor market reform to encourage hiring immigrants in jobs they have been educated for would reduce inefficient allocation of talent to entrepreneurship

Electromagnetic induction mapping at varied soil moisture reveals field-scale soil textural patterns and gravel lenses

Knowledge of the spatial distribution of soil textural properties is important for determining soil moisture storage and soil hydraulic transport properties. Capturing field heterogeneity without exhaustive sampling and costly sample analysis is difficult. Our objective was to employ electromagnetic induction (EMI) mapping in low apparent electrical conductivity (ECa) soils at varying soil water contents to capture time invariant properties such as soil texture. Georeferenced ECa measurements were taken using a ground conductivity meter on six different days where volumetric water content (θv) varied from 0.11 to 0.23. The 50 m × 50 m field included a subsurface gravelly patch in an otherwise homogeneous silt-loam alluvial soil. Ordinary block kriging predicted ECa at unsampled areas to produce 1-m resolution maps. Temporal stability analysis was used to divide the field into three distinct ECa regions. Subsequent ground-truthing confirmed the lowest conductivity region correlated with coarse textured soil parent materials associated with a former high-energy alluvial depositional area. Combining maps using temporal stability analysis gives the clearest image of the textural difference. These maps could be informative for modeling, experimental design, sensor placement and targeted zone management strategies in soil science, ecology, hydrology, and agricultural applications

Ola Bratteli and his diagrams

This article discusses the life and work of Professor Ola Bratteli (1946--2015). Family, fellow students, his advisor, colleagues and coworkers review aspects of his life and his outstanding mathematical accomplishments.Comment: 18 pages, 15 figure

Meningococcal disease in children in Merseyside, England:a 31 year descriptive study

Meningococcal disease (MCD) is the leading infectious cause of death in early childhood in the United Kingdom, making it a public health priority. MCD most commonly presents as meningococcal meningitis (MM), septicaemia (MS), or as a combination of the two syndromes (MM/MS). We describe the changing epidemiology and clinical presentation of MCD, and explore associations with socioeconomic status and other risk factors. A hospital-based study of children admitted to a tertiary children's centre, Alder Hey Children's Foundation Trust, with MCD, was undertaken between 1977 to 2007 (n = 1157). Demographics, clinical presentations, microbiological confirmation and measures of deprivation were described. The majority of cases occurred in the 1-4 year age group and there was a dramatic fall in serogroup C cases observed with the introduction of the meningococcal C conjugate (MCC) vaccine. The proportion of MS cases increased over the study period, from 11% in the first quarter to 35% in the final quarter. Presentation with MS (compared to MM) and serogroup C disease (compared to serogroup B) were demonstrated to be independent risk factors for mortality, with odds ratios of 3.5 (95% CI 1.18 to 10.08) and 2.18 (95% CI 1.26 to 3.80) respectively. Cases admitted to Alder Hey were from a relatively more deprived population (mean Townsend score 1.25, 95% CI 1.09 to 1.41) than the Merseyside reference population. Our findings represent one of the largest single-centre studies of MCD. The presentation of MS is confirmed to be a risk factor of mortality from MCD. Our study supports the association between social deprivation and MCD

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

Significance Alzheimer’s disease (AD) is the most common cause of dementia and is a major public health problem for which there is currently no disease-modifying treatment. There is an urgent need for greater understanding of the molecular mechanisms underlying neurodegeneration in patients to create better therapeutic options. Recently, genetic studies uncovered novel AD risk variants in the microglial receptor, triggering receptor expressed on myeloid cells 2 (TREM2). Previous studies suggested that loss of TREM2 function worsens amyloid-β (Aβ) plaque-related toxicity. In contrast, we observe TREM2 deficiency mitigates neuroinflammation and protects against brain atrophy in the context of tau pathology. These findings indicate dual roles for TREM2 and microglia in the context of amyloid versus tau pathology, which are important to consider for potential treatments targeting TREM2.</jats:p

The potential for modification in cloning and vitrification technology to enhance genetic progress in beef cattle in Northern Australia

AbstractRecent advances in embryology and related research offer considerable possibilities to accelerate genetic improvement in cattle breeding. Such progress includes optimization and standardization of laboratory embryo production (in vitro fertilization – IVF), introduction of a highly efficient method for cryopreservation (vitrification), and dramatic improvement in the efficiency of somatic cell nuclear transfer (cloning) in terms of required effort, cost, and overall outcome. Handmade cloning (HMC), a simplified version of somatic cell nuclear transfer, offers the potential for relatively easy and low-cost production of clones. A potentially modified method of vitrification used at a centrally located laboratory facility could result in cloned offspring that are economically competitive with elite animals produced by more traditional means. Apart from routine legal and intellectual property issues, the main obstacle that hampers rapid uptake of these technologies by the beef cattle industry is a lack of confidence from scientific and commercial sources. Once stakeholder support is increased, the combined application of these methods makes a rapid advance toward desirable traits (rapid growth, high-quality beef, optimized reproductive performance) a realistic goal. The potential impact of these technologies on genetic advancement in beef cattle herds in which improvement of stock is sought, such as in northern Australia, is hard to overestimate