Aquaculture Law in the North Central States: A Digest of State Statutes Pertaining to the Production and Marketing of Aquacultural Products

One of the barriers to the growth and development of the aquaculture industry in the 12-state North Central region is a lack of comprehensive information on the state laws and regulations that affect the industry. The North Central Regional Aquaculture Center and its advisory committees quickly recognized this problem and made it one of their highest priorities for research. Among the factors that cause the confusion are the many aspects or stages of producing and marketing aquacultural products. The long and complex chain of production, transportation and marketing may include issues such as land use planning and zoning, water pollution and state fisheries regulations, transportation requirements and food quality standards. Many public policies and a wide variety of public agencies are involved in regulating these aspects of aquacultural production and marketing

Vegetación natural y acción antrópica de los últimos 1000 años en el sistema prehispánico de canales artificiales del Caño Carate en San Marcos (Sucre, Colombia)

The research conducted compromises an analysis of pollen samples taken at the 25 Carate site, an alluvial plain of the Lower San Jorge river, located in San Marcos, Sucre, an archaeological survey carried out in the area and C14 analysis. These data allowed us the identification of climatic cycles (alternation of humid and dry periods, but also, levels of flood ing), as well as their fluviomorphological (changes in the rate of sedimentation) and ecological consequences (dominance of forest versus savanna vegetation, and swamp or flooding conditions. In connection with such evolution process, changes in resource exploitation systems were traced out. The pollen profile covers a period of time of at least 800 years, since 1010 A. D. to the present. The pollen analysis indicated that the dominance of savanna vegetation is associated with periods of drought, thus indicating that management of the artificial channels was successful. The research also provides a glimpse at land scape changes occurred from the prehispanic occupation period of the region until nowadays, in which savanna conditions prevail in most of the area previously covered by the forest vegetation.A partir del análisis de muestras palinológicas de Carate 25, planicie aluvial del bajo río San Jorge ubicada en el municipio de San Marcos (Sucre, Colombia), de las investigacion es arqueológicas realizadas en dicha región y de los datos cronológicos obtenidos por C14, fue posible establecer los ciclos climáticos (alternancia de períodos secos y húmedos, y de niveles de inundación bajos y altos con duración variable) y sus consecuencias fluviomorfológicas (cambios en las tasas de sedimentación) y ecológicas (predominancia relativa de vegetación de bosque vs. vegetación de sabana y de condiciones de pantano o inundación). Asociados con esta dinámica, se determinaron cambios históricos en los sistemas de aprovechamiento de los recursos. El perfil de polen cubre un rango temporal de por lo menos 800 años: desde el 1010 d.C. hasta el presente, y él se encuentra una relación entre el predominio de vegetación abierta o Sabana asociada con épocas de sequía, pudiéndose advertir que el manejo de sistemas de canales era exitoso. Así mismo, es importante ver las alteraciones que se han dado en el paisaje desde la época de ocupación por parte de grupos prehispánicos, cuando la región se encontraba cubierta de numerosos parches boscosos, hasta hoy, cuando se hallan enormes zonas cubiertas de Sabana con muy escasas zonas de vegetación arbustiva y la desaparición casi total de la vegetación de bosque. 

Amoeba predation of <i>Cryptococcus</i>:A quantitative and population genomic evaluation of the accidental pathogen hypothesis

The “Amoeboid Predator-Fungal Animal Virulence Hypothesis” posits that interactions with environmental phagocytes shape the evolution of virulence traits in fungal pathogens. In this hypothesis, selection to avoid predation by amoeba inadvertently selects for traits that contribute to fungal escape from phagocytic immune cells. Here, we investigate this hypothesis in the human fungal pathogens Cryptococcus neoformans and Cryptococcus deneoformans. Applying quantitative trait locus (QTL) mapping and comparative genomics, we discovered a cross-species QTL region that is responsible for variation in resistance to amoeba predation. In C. neoformans, this same QTL was found to have pleiotropic effects on melanization, an established virulence factor. Through fine mapping and population genomic comparisons, we identified the gene encoding the transcription factor Bzp4 that underlies this pleiotropic QTL and we show that decreased expression of this gene reduces melanization and increases susceptibility to amoeba predation. Despite the joint effects of BZP4 on amoeba resistance and melanin production, we find no relationship between BZP4 genotype and escape from macrophages or virulence in murine models of disease. Our findings provide new perspectives on how microbial ecology shapes the genetic architecture of fungal virulence, and suggests the need for more nuanced models for the evolution of pathogenesis that account for the complexities of both microbe-microbe and microbe-host interactions

The Nucleosome Remodelling and Deacetylation complex suppresses transcriptional noise during lineage commitment.

Multiprotein chromatin remodelling complexes show remarkable conservation of function amongst metazoans, even though components present in invertebrates are often found as multiple paralogous proteins in vertebrate complexes. In some cases, these paralogues specify distinct biochemical and/or functional activities in vertebrate cells. Here, we set out to define the biochemical and functional diversity encoded by one such group of proteins within the mammalian Nucleosome Remodelling and Deacetylation (NuRD) complex: Mta1, Mta2 and Mta3. We find that, in contrast to what has been described in somatic cells, MTA proteins are not mutually exclusive within embryonic stem (ES) cell NuRD and, despite subtle differences in chromatin binding and biochemical interactions, serve largely redundant functions. ES cells lacking all three MTA proteins exhibit complete NuRD loss of function and are viable, allowing us to identify a previously unreported function for NuRD in reducing transcriptional noise, which is essential for maintaining a proper differentiation trajectory during early stages of lineage commitment.Funding to the BH and MV labs was provided through EU FP7 Integrated Project “4DCellFate” (277899). The BH lab further benefitted from a Wellcome Trust Senior Fellowship (098021/Z/11/Z) and from core funding to the Cambridge Stem Cell Institute from the Wellcome Trust and Medical Research Council (097922/Z/11/Z and 203151/Z/16/Z). The Vermeulen lab is part of the Oncode Institute, which is partly funded by the Dutch Cancer Society (KWF)

Acute liver toxicity with ifosfamide in the treatment of sarcoma: a case report

<p>Abstract</p> <p>Introduction</p> <p>Ifosfamide is a chemotherapy agent infrequently associated with liver toxicity. To the best of our knowledge, this report is the first to describe serious liver toxicity associated with ifosfamide used in combination with doxorubicin that caused acute but fully reversible liver failure and encephalopathy. This report reviews the possible mechanisms by which ifosfamide causes this adverse effect.</p> <p>Case report</p> <p>A 61-year-old Caucasian woman who presented with an inoperable right neck mass due to synovial sarcoma was treated with standard-dose ifosfamide and doxorubicin. Within 24 hours of completing the first cycle of chemotherapy, she developed significant derangements in liver function, with a 250-fold increase in transaminase and associated synthetic function impairment and encephalopathy. No other causes of liver failure were identified. Both biochemical tests and encephalopathy were reversed after supportive management and treatment with <it>N</it>-acetylcysteine. No liver toxicity was observed with subsequent cycles of chemotherapy with doxorubicin alone.</p> <p>Conclusion</p> <p>This case highlights the possibility that chemotherapy agents can cause rare and idiosyncratic toxicities, so physicians must be vigilant for drug reactions, especially when patients do not respond to usual treatment.</p

Acute liver toxicity with ifosfamide in the treatment of sarcoma: a case report

<p>Abstract</p> <p>Introduction</p> <p>Ifosfamide is a chemotherapy agent infrequently associated with liver toxicity. To the best of our knowledge, this report is the first to describe serious liver toxicity associated with ifosfamide used in combination with doxorubicin that caused acute but fully reversible liver failure and encephalopathy. This report reviews the possible mechanisms by which ifosfamide causes this adverse effect.</p> <p>Case report</p> <p>A 61-year-old Caucasian woman who presented with an inoperable right neck mass due to synovial sarcoma was treated with standard-dose ifosfamide and doxorubicin. Within 24 hours of completing the first cycle of chemotherapy, she developed significant derangements in liver function, with a 250-fold increase in transaminase and associated synthetic function impairment and encephalopathy. No other causes of liver failure were identified. Both biochemical tests and encephalopathy were reversed after supportive management and treatment with <it>N</it>-acetylcysteine. No liver toxicity was observed with subsequent cycles of chemotherapy with doxorubicin alone.</p> <p>Conclusion</p> <p>This case highlights the possibility that chemotherapy agents can cause rare and idiosyncratic toxicities, so physicians must be vigilant for drug reactions, especially when patients do not respond to usual treatment.</p