The Geographical Patterns of Socio-Economic Well-Being of First Nations Communities in Canada

Community/Rural/Urban Development, Labor and Human Capital,

Strengthening the Campus Leadership Team through Effective Principal and Counselor Relationships: Implications for Training

Campuses with successful leadership teams have a better opportunity to meet the ever-increasing and complex needs of the students they serve (Crowther, Kaagan, Ferguson, & Hann, 2002). These successful campuses are strengthened when they include strong principals and counseling teams with shared mutual trust and understanding that permeates the school climate (DeVoss & Andrews, 2006). A review of the literature revealed a paucity of studies examining the nature of successful principal-counselor relations and the impact of this relationship on student success, effective campus leadership teams, and an effective school climate that promotes learning. Meaningful dialogue and discussion of this critical professional relationship also were found lacking in the major counseling and educational leadership professional journals

Teen Voices from the City: How School Instrumental Music Students Persevere and Thrive

High school bands and orchestras in the United States reflect the rampant educational opportunity gap when it comes to the representation of Black, Indigenous, and people of color (BIPOC) student populations, denying talented and passionate students the opportunities intrinsic to instrumental music participation (IMP) (Bradley, 2007; Elpus & Abril, 2011; Kozol, 2005; Salvador & Allegood, 2014; Stanford CEPA). The study’s purpose was to understand how BIPOC students successfully participated in high school instrumental music (IM) ensembles. Using the theoretical lenses of Maslow’s (2015) hierarchy of needs and Freire’s (2013) critical pedagogy, this study asked: How do teenage BIPOC IM students experience, and make meaning of, their public-school IM journeys? Including, Who supported them?; What were the transitional points of decision?; What were the IM bonds that kept them participating? Using a constructivist phenomenological approach, this qualitative study interviewed 12 BIPOC high school graduates of a Midwest metropolitan area to learn how they made meaning of their IM journeys. Several common themes emerged. Participants’ IM journeys were supported by family, peers, and IM teachers. Transition points included high school entrance, structural crises, and exclusionary experiences. IMP bonds to continuing IMP included mood, social connection, self-esteem/challenge, aesthetics, and agency themes. Recommendations include investment in equitable, culturally responsive IM programming and recruiting; targeted guidance and bridging strategies for high school IM transitions, private lessons for advanced students of low SES, the use of collaborative student-centered teaching strategies and culturally relevant literature; and targeted, caring anti-racist polices and strategies toward inclusion

Reclassification at a Glance

Poster demonstrating the impact of the projects delivered as part of Information Services' shelf ready strategy for the Templeman Library and Tonbridge Centre library of the University of Ken

Native socio-economic development in Canada : adaptation, accessibility and opportunity

iii, 55 p., digital fil

Epigenetic regulation of DNA replication in Drosophila melanogaster

How origins of DNA replication are specified and activated in the context of an intact metazoan genome remains poorly understood. In contrast to Saccharomyces cerevisiae, replication initiation in metazoan genomes is not directed by well-defined sequence motifs. Rather, local chromatin environments have emerged as potential regulators of replication, yielding early and late replicating regions of the genome. Transcriptionally active, accessible euchromatin typically replicates early during S phase, whereas transcriptionally repressive, inaccessible heterochromatin typically replicates late. Current models of replication posit a stochastic process in which a higher density of specified origins in euchromatin compared to heterochromatin increases the probability of replication initiation, resulting in the earlier replication of euchromatin relative to heterochromatin. Despite strong genome-wide correlations between replication and chromatin, a true causal relationship between the two has yet to be determined. We investigated how chromatin organization impacts replication in Drosophila using our genetic platform in which endogenous histone genes are replaced with transgenic histone genes encoding mutations that prevent modification of specific histone residues. To explore the relationship between euchromatin and replication, we implemented a whole-genome sequencing method to produce genome-wide replication timing profiles. We analyzed the X Chromosome, which in Drosophila is 2-fold more transcriptionally active, replicates earlier, and is hyper-acetylated at H4K16 in XY males relative to XX females. H4K16R mutation prevents transcriptional hyper-activation and earlier replication of the male X chromosome, consistent with the notion that transcription promotes early replication. To determine whether perturbation of heterochromatin affects late replication, we generated replication profiles from H3K9R mutant tissue. Despite well-known correlations between late replication and heterochromatin, perturbation of heterochromatin structure through H3K9R mutation does not result in large-scale changes in replication timing suggesting critical regulation beyond chromatin structure. To identify other contributors to replication timing control, we explored the relative contributions of cell lineage, cell cycle, and the trans-acting factor Rif1. We identified that cell lineage, rather than changes in cell cycle status, drive replication timing programs. Furthermore, Rif1 regulates replication timing in a tissue-specific manner supporting the notion that additional mechanisms beyond chromatin structure are key regulators of replication of metazoan genomes.Doctor of Philosoph

Micro-mechanical testing by fibre pushout of the BN interlayer in SiCf/SiC composites for aero-propulsion

Ceramic Matrix Composites (CMC’s) are finding renewed interest in the aerospace community for use as high temperature components in engines due to the potential for cooling air reductions over metallic parts, amongst other benefits such as weight saving and improving the turbine blade clearance. Quasi-brittle SiCf/SiC composites are toughened by the application of a boron nitride interphase coating to the fibre, which allows for cracks to deviate from the matrix. The principal issues faced by SiC-based composites lie in their degradation in corrosive environments (changing the interphase region and embrittling the overall composite) and their current inadequacy to adopt performance life models. Therefore, maintaining the interfacial properties of the composite at high temperatures is crucial. The extraction of these said properties has however proven itself to be a major engineering challenge in materials science. A few meso-scale and macro-scale techniques such as the transverse bend test and the Brazilian disc compression test have shown experimental reproducibility but are unsupported by sufficient modelling. The most accurate method for determining the properties at the micro-scale remains the push-out method on singular fibres. Herein the talk will present current both advances in using the fibre push-out method and some of the challenges to overcome with push-outs in order to accurately measure the interfacial shear stresses, coefficients of friction and residual compressive stresses at the fibre/matrix interface. The push-out method will be contrasted to the fibre push-back and push-in techniques and a novel \u27via\u27 push-out method will be introduced. Finally, suggestions for improving the method to corroborate with ongoing modelling work will be showcased

Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in Drosophila

The methylation state of lysine 20 on histone H4 (H4K20) has been linked to chromatin compaction, transcription, DNA repair and DNA replication. Monomethylation of H4K20 (H4K20me1) is mediated by the cell cycle-regulated histone methyltransferase PR-Set7. PR-Set7 depletion in mammalian cells results in defective S phase progression and the accumulation of DNA damage, which has been partially attributed to defects in origin selection and activation. However, these studies were limited to only a handful of mammalian origins, and it remains unclear how PR-Set7 and H4K20 methylation impact the replication program on a genomic scale. We employed genetic, cytological, and genomic approaches to better understand the role of PR-Set7 and H4K20 methylation in regulating DNA replication and genome stability in Drosophila cells. We find that deregulation of H4K20 methylation had no impact on origin activation throughout the genome. Instead, depletion of PR-Set7 and loss of H4K20me1 results in the accumulation of DNA damage and an ATR-dependent cell cycle arrest. Coincident with the ATR-dependent cell cycle arrest, we find increased DNA damage that is specifically limited to late replicating regions of the Drosophila genome, suggesting that PR-Set7-mediated monomethylation of H4K20 is critical for maintaining the genomic integrity of late replicating domains

Mobilizing Volunteer Tutors to Improve Student Literacy

This report evaluates the implementation, impacts, and costs of Reading Partners, a school-based early-intervention literacy program that relies on volunteer tutors. The work is a partnership between MDRC and CBCSE. The findings illustrate that the program is an efficient option for schools to consider in providing supplemental reading services to students who are not reading at grade-level