Defining the methodological challenges and opportunities for an effective science of sociotechnical systems and safety

An important part of the application of sociotechnical systems theory (STS) is the development of methods, tools and techniques to assess human factors and ergonomics workplace requirements. We focus in this paper on describing and evaluating current STS methods for workplace safety, as well as outlining a set of six case studies covering the application of these methods to a range of safety contexts. We also describe an evaluation of the methods in terms of ratings of their ability to address a set of theoretical and practical questions (e.g. the degree to which methods capture static/dynamic aspects of tasks and interactions between system levels). The outcomes from the evaluation highlight a set of gaps relating to the coverage and applicability of current methods for STS and safety (e.g. coverage of external influences on system functioning; method usability). The final sections of the paper describe a set of future challenges, as well as some practical suggestions for tackling thes

Growth and persistence of 17 annual medic (Medicago spp.) accessions on clay soils in central Queensland

Seventeen accessions of annual medics were evaluated on clay soil sites at Emerald, Theodore, Biloela and Mundubbera, central Queensland. Successful medics could have a role in both permanent and ley pastures. However, these are marginal areas for medics with winter (June-August) rainfalls of 80-100 mm. The accessions were selected on the basis of results in southern Queensland, a more favoured area for medics. There were 9 accessions of Medicago truncatula (barrel medic), 4 of M. scutellata (snail medic), 2 of M. polymorpha (burr medic) and 1 each of M. aculeata (keg medic) and M. orbicularis (button medic). Lucerne (M. sativa) cv. Trifecta was sown at 3 sites. All sites except Theodore were irrigated in the year of establishment (1993). The medic seedlings at Theodore died in 1993 and the trial was resown in 1994. Measurements were made of seed set in the first year and whenever it occurred in later years, seedling density in most years and yield when there was adequate growth. Selected measurements were made of soil seed reserves. Measurements ceased in 1998

Towards effective capacity planning in a perinatal network centre

Objective To study the arrival pattern and length of stay (LoS) in a neonatal intensive care/high dependency unit (NICU/HDU) and special care baby unit (SCBU) and the impact of capacity shortage in a perinatal network centre, and to provide an analytical model for improving capacity planning. Methods The data used in this study have been collected through the South England Neonatal Database (SEND) and the North Central London Perinatal Network Transfer Audit between 1 January and 31 December 2006 for neonates admitted and refused from the neonatal unit at University College London Hospital (UCLH). Exploratory data analysis was performed. A queuing model is proposed for capacity planning of a perinatal network centre. Outcome measures Predicted number of cots required with existing arrival and discharge patterns; impact of reducing LoS. Results In 2006, 1002 neonates were admitted to the neonatal unit at UCLH, 144 neonates were refused admission to the NICU and 35 to the SCBU. The model shows the NICU requires seven more cots to accept 90% of neonates into the NICU. The model also shows admission acceptance can be increased by 8% if LoS can be reduced by 2 days. Conclusions The arrival, LoS and discharge of neonates having gestational ages of <27 weeks were the key determinants of capacity. The queuing model can be used to determine the cot capacity required for a given tolerance level of admission rejection

The Extracellular Vesicle Citrullinome and Signature in a Piglet Model of Neonatal Seizures

Neonatal seizures are commonly associated with acute perinatal brain injury, while understanding regarding the downstream molecular pathways related to seizures remains unclear. Furthermore, effective treatment and reliable biomarkers are still lacking. Post-translational modifications can contribute to changes in protein function, and post-translational citrullination, which is caused by modification of arginine to citrulline via the calcium-mediated activation of the pep-tidylarginine deiminase (PAD) enzyme family, is being increasingly linked to neurological injury. Extracellular vesicles (EVs) are lipid-bilayer structures released from cells; they can be isolated from most body fluids and act as potential liquid biomarkers for disease conditions and response to treatment. As EVs carry a range of genetic and protein cargo that can be characteristic of pathological processes, the current study assessed modified citrullinated protein cargo in EVs isolated from plasma and CSF in a piglet neonatal seizure model, also following phenobarbitone treatment. Our findings provide novel insights into roles for PAD-mediated changes on EV signatures in neonatal seizures and highlight the potential of plasma-and CSF-EVs to monitor responses to treatment

Northern European trees show a progressively diminishing response to increasing atmospheric carbon dioxide concentrations

In order to predict accurately how elevated atmospheric CO2 concentrations will affect the global carbon cycle, it is necessary to know how trees respond to increasing CO2 concentrations. In this paper we examine the response over the period AD 1895 – 1994 of three tree species growing across northern Europe to increases in atmospheric CO2 concentrations using parameters derived from stable carbon isotope ratios of trunk cellulose. Using the isotope data we calculate values of intrinsic water-use efficiency (IWUE) and intercellular CO2 concentrations in the leaf (ci). Our results show that trees have responded to higher levels of atmospheric CO2 by increasing IWUE whilst generally maintaining constant ci values. However, the IWUE of most of the trees in this study has not continued to rise in line with increasing atmospheric CO2. This behaviour has implications for estimations of future terrestrial carbon storage

On the purification of α-cellulose from resinous wood for stable isotope (H, C and O) analysis

α-Cellulose was isolated from four samples of Scots pine (Pinus sylvestris L.). Each sample was divided into two portions. One portion had the resins removed by solvent extraction prior to removal of lignins by treatment with acidic sodium chlorite solution and treatment with sodium hydroxide solution to remove hemicelluloses. The other portion was processed in the same way apart from the solvent extraction step. The isolated wood constituents were characterised by attenuated total reflectance Fourier transform infrared (ATR/FT-IR) spectroscopy. The infrared spectra of the resulting α-cellulose samples were identical indicating that treatment with acidic sodium chlorite and sodium hydroxide was sufficient to remove resins. The values of the stable isotope ratios (carbon, oxygen and hydrogen) for each pair of α-cellulose sub-samples also showed no significant differences within the reproducibility of the methods. The implication of these studies demonstrate that the customary step of resin extraction from pine is unnecessary if sodium chlorite and sodium hydroxide are used for the isolation of α-cellulose following the technique described in this paper. In addition, the study demonstrates that the oxygen isotope ratio of the water used for cellulose extraction does not influence the stable isotope values in the α-cellulose obtained. The importance of isotopic homogeneity within the cellulose sample is also highlighted

Fit for what?: towards explaining Battlegroup inaction

The thrust of this paper concerns the case of the European Battlegroup (BG) non-deployment in late 2008, when the United Nations requested European military support for the United Nations Organisation Mission peacekeeping force in the Democratic Republic of the Congo (DRC). The argument is built on the fact that when, in official documents, the EU approaches the European security and ESDP/CSDP's military crisis management policy and interventions, it makes strong references to the United Nations and the UN Charter Chapter VII's mandate of restoring international peace and security. Such references make it seem that supporting the UN when it deals with threats and crises is a primary concern of the EU and the member states. These allusions lead to the main contention of this paper, that there is much ambivalence in these indications. The paper develops its argument from one key hypothesis; namely, that the non-deployment of a European BG in the DRC, at the end of 2008, constitutes a useful case study for detecting a number of ambiguities of the EU in respect of its declarations in the official documents establishing the European military crisis management intervention structure

Interstellar MHD Turbulence and Star Formation

This chapter reviews the nature of turbulence in the Galactic interstellar medium (ISM) and its connections to the star formation (SF) process. The ISM is turbulent, magnetized, self-gravitating, and is subject to heating and cooling processes that control its thermodynamic behavior. The turbulence in the warm and hot ionized components of the ISM appears to be trans- or subsonic, and thus to behave nearly incompressibly. However, the neutral warm and cold components are highly compressible, as a consequence of both thermal instability in the atomic gas and of moderately-to-strongly supersonic motions in the roughly isothermal cold atomic and molecular components. Within this context, we discuss: i) the production and statistical distribution of turbulent density fluctuations in both isothermal and polytropic media; ii) the nature of the clumps produced by thermal instability, noting that, contrary to classical ideas, they in general accrete mass from their environment; iii) the density-magnetic field correlation (or lack thereof) in turbulent density fluctuations, as a consequence of the superposition of the different wave modes in the turbulent flow; iv) the evolution of the mass-to-magnetic flux ratio (MFR) in density fluctuations as they are built up by dynamic compressions; v) the formation of cold, dense clouds aided by thermal instability; vi) the expectation that star-forming molecular clouds are likely to be undergoing global gravitational contraction, rather than being near equilibrium, and vii) the regulation of the star formation rate (SFR) in such gravitationally contracting clouds by stellar feedback which, rather than keeping the clouds from collapsing, evaporates and diperses them while they collapse.Comment: 43 pages. Invited chapter for the book "Magnetic Fields in Diffuse Media", edited by Elisabete de Gouveia dal Pino and Alex Lazarian. Revised as per referee's recommendation

Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment

This paper describes an analysis of the angular distribution of W->enu and W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with the ATLAS detector at the LHC in 2010, corresponding to an integrated luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and the missing transverse energy, the W decay angular distribution projected onto the transverse plane is obtained and analysed in terms of helicity fractions f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw > 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour, are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017 +/- 0.030, where the first uncertainties are statistical, and the second include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables, revised author list, matches European Journal of Physics C versio