A Search for γ\gamma Doradus-Type Variable Stars in the Hyades

$\gamma$ Doradus stars are photometrically variable early F-type stars on or just above the main sequence in the Hertzsprung-Russell Diagram. They vary by as much as 0.1 mag on time scales an order of magnitude slower than the fundamental radial pulsation period. These brightness variations are presumably due to non-radial gravity-mode pulsations. We obtained high precision $V$-band photometry of 8 F0 to F5 stars in the Hyades (BS 1319, BS 1354, BS 1385, BS 1408, BS 1430, BS 1432, BS 1459, and BS 1472) and found that none of them showed strong evidence of $\gamma$ Dor-type variability. Since $\gamma$ Dor-type candidates are found in the Pleiades and in NGC 2516 (having ages of 78 and 137 Myr, repectively) but apparently not in the Hyades (age $>$ 600 Myr), we hypothesize that the $\gamma$ Dor phenomenon is a characteristic of relatively young F stars. Two of the stars investigated showed marginal evidence of low-amplitude variability. The $\pm$3 mmag variability of the F5 star BS 1319 is most likely due to rotational modulation of star spots, though it is not impossible that it is a $\gamma$ Dor star. Another F5 star BS 1459 ($\Delta V = \pm 2$ mmag) has a possible period similar to $\delta$ Scuti stars, but no firm conclusions should be made concerning its behavior unless and until its variability is confirmed.Comment: 8 pages, Latex, uses MN.STY, 6 figures, available via Fax or regular pos

Changes in Producers’ Perceptions of Within-field Yield Variability Following Adoption of Cotton Yield Monitors

Precision Farming, Risk, Yield Monitor, Yield Variability, Yield Perceptions, Spatial Yield Distributions, Within Field Variability, Farm Management, Production Economics, Risk and Uncertainty, Q12, Q16,

Sodium binding sites and permeation mechanism in the NaChBac channel:a molecular dynamics study

NaChBac was the first discovered bacterial sodium voltage-dependent channel, yet computational studies are still limited due to the lack of a crystal structure. In this work, a pore-only construct built using the NavMs template was investigated using unbiased molecular dynamics and metadynamics. The potential of mean force (PMF) from the unbiased run features four minima, three of which correspond to sites IN, CEN, and HFS discovered in NavAb. During the run, the selectivity filter (SF) is spontaneously occupied by two ions, and frequent access of a third one is often observed. In the innermost sites IN and CEN, Na+ is fully hydrated by six water molecules and occupies an on-axis position. In site HFS sodium interacts with a glutamate and a serine from the same subunit and is forced to adopt an off-axis placement. Metadynamics simulations biasing one and two ions show an energy barrier in the SF that prevents single-ion permeation. An analysis of the permeation mechanism was performed both computing minimum energy paths in the axial–axial PMF and through a combination of Markov state modeling and transition path theory. Both approaches reveal a knock-on mechanism involving at least two but possibly three ions. The currents predicted from the unbiased simulation using linear response theory are in excellent agreement with single-channel patch-clamp recording

Alcohol consumption and leukocyte telomere length.

The relationship between alcohol consumption and mortality generally exhibits a U-shaped curve. The longevity observed with moderate alcohol consumption may be explained by other confounding factors, and, if such a relationship is present, the mechanism is not well understood. Indeed, the optimal amount of alcohol consumption for health has yet to be determined. Leukocyte telomere length is an emerging quantifiable marker of biological age and health, and a shorter telomere length is a predictor of increased mortality. Because leukocyte telomere length is a quantifiable and objectively measurable biomarker of aging, we sought to identify the amount of alcohol consumption associated with the longest telomere length and least telomere length attrition. Among over 2,000 participants from two distinct cohort studies, we found no pattern of alcohol consumption that was associated with longer telomere length or less telomere length attrition over time. Binge drinking may reduce telomere length. Using telomere length as a marker of age and health, these data fail to demonstrate any benefits of alcohol consumption, even when consumed in moderation

Factors Influencing Adoption of Remotely Sensed Imagery for Site-Specific Management in Cotton Production

This research evaluated the factors that influenced cotton producers to adopt remote sensing for variable rate application of inputs. Farmers who were younger, more highly educated, had a larger farm operation, and were more technologically savvy were more likely to have adopted remote sensing.Crop Production/Industries, Research and Development/Tech Change/Emerging Technologies,

Towards Precision Medicine: Therapeutic Drug Monitoring–Guided Dosing of Vancomycin and β-lactam Antibiotics to Maximize Effectiveness and Minimize Toxicity

Purpose The goal of this review is to explore the role of antimicrobial therapeutic drug monitoring (TDM), especially in critically ill, obese, and older adults, with a specific focus on β-lactams and vancomycin. Summary The continued rise of antimicrobial resistance prompts the need to optimize antimicrobial dosing. The aim of TDM is to individualize antimicrobial dosing to achieve antibiotic exposures associated with improved patient outcomes. Initially, TDM was developed to minimize adverse effects during use of narrow therapeutic index agents. Today, patient and organism complexity are expanding the need for precision dosing through TDM services. Alterations of pharmacokinetics and pharmacodynamics (PK/PD) in the critically ill, obese, and older adult populations, in conjunction with declining organism susceptibility, complicate attainment of therapeutic targets. Over the last decade, antimicrobial TDM has expanded with the emergence of literature supporting β-lactam TDM and a shift from monitoring vancomycin trough concentrations to monitoring of the ratio of area under the concentration (AUC) curve to minimum inhibitory concentration (MIC). PK/PD experts should be at the forefront of implementing precision dosing practices. Conclusion Precision dosing through TDM is expanding and is especially important in populations with altered PK/PD, including critically ill, obese, and older adults. Due to wide PK/PD variability in these populations, TDM is vital to maximize antimicrobial effectiveness and decrease adverse event rates. However, there is still a need for studies connecting TDM to patient outcomes. Providing patient-specific care through β-lactam TDM and transitioning to vancomycin AUC/MIC monitoring may be challenging, but with experts at the forefront of this initiative, PK-based optimization of antimicrobial therapy can be achieved

Adoption of Conservation-Tillage Practices in Cotton Production

Replaced with revised version of paper 10/23/07.conservation tillage, cotton, genetically modified seed, herbicide-resistant cotton, stacked-gene cotton, simultaneous logit model, single-equation logit model, technology adoption, Crop Production/Industries,

A Binary Logit Estimation of Factors Affecting Adoption of GPS Guidance Systems by Cotton Producers

Binary logit analysis was used to identify the factors influencing adoption of Global Positioning System (GPS) guidance systems by cotton farmers in 11 Mid-south and Southeastern states. Results indicate that adoption was more likely by those who had already adopted other precision-farming practices and had used computers for farm management. In addition, younger and more affluent farmers were more likely to adopt. Farmers with larger farms and with relatively high yields were also more likely to adopt. Education was not a significant factor in a farmer’s decision to adopt GPS guidance systems.binary logit, cotton, GPS guidance system, marginal effect, precision farming, technology adoption, Agribusiness, Crop Production/Industries, Q2, Q16, Q19, Q20, Q24,