Optical extinction, refractive index, and multiple scattering for suspensions of interacting colloidal particles

We provide a general microscopic theory of the scattering cross-section and of the refractive index for a system of interacting colloidal particles, exact at second order in the molecular polarizabilities. In particular: a) we show that the structural features of the suspension are encoded into the forward scattered field by multiple scattering effects, whose contribution is essential for the so-called "optical theorem" to hold in the presence of interactions; b) we investigate the role of radiation reaction on light extinction; c) we discuss our results in the framework of effective medium theories, presenting a general result for the effective refractive index valid, whatever the structural properties of the suspension, in the limit of particles much larger than the wavelength; d) by discussing strongly-interacting suspensions, we unravel subtle anomalous dispersion effects for the suspension refractive index.Comment: Submitted to Journal of Chemical Physics 37 pages, 4 figure

NTRK Gene Fusions in Solid Tumors and TRK Inhibitors: A Systematic Review of Case Reports and Case Series

The approval of larotrectinib and entrectinib for cancer patients harboring an NTRK gene fusion has represented a milestone in the era of "histology-agnostic" drugs. Among the clinical trials that led to the approval of these two drugs, most of the enrolled patients were affected by soft tissue sarcomas, lung, and salivary gland cancer. However, as next-generation sequencing assays are increasingly available in the clinical setting, health care professionals may be able to detect NTRK gene fusions in patients affected by tumor types under or not represented in the clinical trials. To this aim, we systematically reviewed MEDLINE from its inception to 31 August 2022 for case reports and case series on patients with NTRK gene fusion-positive tumors treated with TRK inhibitors. A virtual cohort of 43 patients was created, excluding those enrolled in the above-mentioned clinical trials. Although our results align with those existing in the literature, various cases of central nervous system tumors were registered in our cohort, confirming the benefit of these agents in this subgroup of patients. Large, multi-institutional registries are needed to provide more information about the efficacy of TRK inhibitors in cancer patients affected by tumor types under or not represented in the clinical trials

El intercambio de ideas en acción: la experiencia de la asignatura de Economía Ecológica

Incorporada en el año 2008, la materia de Economía Ecológica ha hecho irrupción en las carreras de la Facultad de Ciencias Económicas a partir de enfoque teórico crítico en la mirada de la economía hacia el medio ambiente, con un fundamento interdisciplinario. Uno de los elementos innovadores ha sido la implementación de clases de debate/expansión e integración de alumnos de diferentes carreras de la facultad y de otras facultades que toman el curso como alumnos vocacionales o como materia optativa. El resultado ha sido enriquecedor: las opiniones desde diferentes posiciones, diferentes estudios ha generado una mayor participación, reflexión y motivación por la materia.https://rdu.unc.edu.ar/handle/11086/6472Fil: Iturralde, Ivan. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Domenech, Roberto. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Torrico, Julieta. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Estigarribia, Lucrecia. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Gohlke, Guillermo. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Rosenfeld, Valeria. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Montejano, Franco. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Atienza, Bárbara. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Otras Ciencias Sociale

A Comment on the Implementation of the Strategy of Reinvigorating our Country through trained personnel in terms of Strategic Management

当今世界，以知识为主导、以高新技术及其产业为基础和支撑的知识经济已经悄然来临，世界范围内综合国力的竞争日趋激烈。这种竞争，说到底是人才的竞争，实质上就是人才战略的竞争。中国作为世界上最大的发展中国家，人口多，底子薄，人均资源相对不足，这一基本国情决定了中国的发展必须坚持“以人为本”，走人才强国之路。在2003年全国人才工作会议上，把实施人才强国战略作为科学发展观的有机组成部分，作为党和国家一项重大而紧迫的任务，作为新世纪新阶段国家人才工作的根本任务。“十一五”规划进一步提出了加快推进人才强国战略，为我国政治、经济、社会的发展提供智力支持。因此，在现阶段研究人才强国战略的实施具有重大的战略意义。...In our times, the knowledge economy that took knowledge as the leading factor, is based on new and high technology and industry. It has already come quietly. The competition of the comprehensive national strength is becoming fiercer and fiercer in the whole world. This kind of competition is talents' competition after all. It is a competition of the talents strategy in fact. As the largest develop...学位：管理学硕士院系专业：公共事务学院公共管理系_行政管理学号：20030603

Loss of Neuron Navigator 2 Impairs Brain and Cerebellar Development

Acknowledgements We thank the study family for their enthusiastic participationPeer reviewedPublisher PD

Intracameral bevacizumab and mitomycin C Trabeculectomy for eyes with neovascular glaucoma: a case series

The purpose of this study was to describe the surgical outcomes and safety of intracameral bevacizumab during trabeculectomy in eyes with neovascular glaucoma. Pilot study included four eyes (four patients) with refractory neovascular glaucoma submitted to fornix-based trabeculectomy with adjunctive use of bevacizumab in the anterior chamber during the procedure. Patients were previously treated with panretinal photocoagulation as standard therapy. Variables evaluated were intraocular pressure, bleb appearance, iris neovascularization, intraoperative/postoperative complications, and visual outcomes. No intraoperative complication was observed. The mean follow-up period was 12.75 (range, 12–15 months). All eyes showed significant intraocular pressure control postoperatively. Iris neovascularization reduced significantly within 1 month after surgery. Mild anterior chamber inflammation was observed during follow-up in all eyes. No significant postoperative complication was observed, and no patient presented visual acuity deterioration. Intracameral bevacizumab may be used as an adjunctive therapy during trabeculectomy in eyes with neovascular glaucoma

DNA Polymerase Epsilon Deficiency Causes IMAGe Syndrome with Variable Immunodeficiency.

During genome replication, polymerase epsilon (Pol ε) acts as the major leading-strand DNA polymerase. Here we report the identification of biallelic mutations in POLE, encoding the Pol ε catalytic subunit POLE1, in 15 individuals from 12 families. Phenotypically, these individuals had clinical features closely resembling IMAGe syndrome (intrauterine growth restriction [IUGR], metaphyseal dysplasia, adrenal hypoplasia congenita, and genitourinary anomalies in males), a disorder previously associated with gain-of-function mutations in CDKN1C. POLE1-deficient individuals also exhibited distinctive facial features and variable immune dysfunction with evidence of lymphocyte deficiency. All subjects shared the same intronic variant (c.1686+32C>G) as part of a common haplotype, in combination with different loss-of-function variants in trans. The intronic variant alters splicing, and together the biallelic mutations lead to cellular deficiency of Pol ε and delayed S-phase progression. In summary, we establish POLE as a second gene in which mutations cause IMAGe syndrome. These findings add to a growing list of disorders due to mutations in DNA replication genes that manifest growth restriction alongside adrenal dysfunction and/or immunodeficiency, consolidating these as replisome phenotypes and highlighting a need for future studies to understand the tissue-specific development roles of the encoded proteins

Cardiac disease in patients with mucopolysaccharidosis: presentation, diagnosis and management

The mucopolysaccharidoses (MPSs) are inherited lysosomal storage disorders caused by the absence of functional enzymes that contribute to the degradation of glycosaminoglycans (GAGs). The progressive systemic deposition of GAGs results in multi-organ system dysfunction that varies with the particular GAG deposited and the specific enzyme mutation(s) present. Cardiac involvement has been reported in all MPS syndromes and is a common and early feature, particularly for those with MPS I, II, and VI. Cardiac valve thickening, dysfunction (more severe for left-sided than for right-sided valves), and hypertrophy are commonly present; conduction abnormalities, coronary artery and other vascular involvement may also occur. Cardiac disease emerges silently and contributes significantly to early mortality