Editorial : Innovations in MR Hardware from Ultra-Low to Ultra-High Field

Peer reviewedPublisher PD

Citizen science approach to assessing patient perception of MRI with flexible radiofrequency coils

Abstract Magnetic Resonance Imaging (MRI) is a major medical imaging modality, which is non-invasive and provides unique soft tissue contrast without ionizing radiation. The successful completion of MRI exams critically depends on patient compliance, and, thus patient comfort. The design, appearance and usability of local MRI radiofrequency (RF) coils potentially influences the patients’ perception of the exam. However, systematic investigations and empirical evidence for these aspects are missing. A questionnaire specifically evaluating the impact of RF coils on patient comfort in MRI would be a valuable addition to clinical studies comparing the performance of novel flexible RF coils with standard rigid coils. This paper describes the development of such a questionnaire in the scope of a citizen science (CS) initiative conducted with a group of students at the upper secondary school level. In this work, the CS initiative is presented in the format of a case report and its impact on scientific projects and the students’ education is outlined. The resulting questionnaire is made available in German and English so as to be directly applicable by researchers working on the clinical evaluation of novel RF coils or the comfort evaluation of specific hardware setups in general

Flexible 23-channel coil array for high-resolution magnetic resonance imaging at 3 Tesla.

PURPOSE:The purpose of this work is the design, implementation and evaluation of a mechanically flexible receive-only coil array for magnetic resonance imaging (MRI) at 3 T that can be applied to various target organs and provides high parallel imaging performance. METHODS:A 23-channel array was designed based on a rigid-flex printed circuit board (PCB). The flexible multi-layer part contains the copper traces forming the coil elements. The rigid part of the PCB houses the solder joints and lumped elements. The coil housing consists of rigid caps mounted above the rigid parts. Adhesive PTFE sheets cover all flexible parts. The developed array was tested on the bench as well as in phantom and in vivo MRI experiments employing parallel imaging acceleration factors up to six. RESULTS:Efficient mutual decoupling between receive elements and detuning between receive array and body coil was achieved. An increased signal-to-noise ratio in comparison to commercial reference coils is demonstrated, especially in regions close to the developed array and for high parallel imaging acceleration factors. Exemplary in vivo images of head, ankle, knee, shoulder and hand are presented. CONCLUSION:Based on high sensitivity close to the array and low g-factors, this flexible coil is well suited for studies of occipital and temporal cortex, as well as musculoskeletal targets like knee, ankle, elbow and wrist

Proton-decoupled carbon magnetic resonance spectroscopy in human calf muscles at 7 T using a multi-channel radiofrequency coil

13C magnetic resonance spectroscopy is a viable, non-invasive method to study cell metabolism in skeletal muscles. However, MR sensitivity of 13C is inherently low, which can be overcome by applying a higher static magnetic field strength together with radiofrequency coil arrays instead of single loop coils or large volume coils, and 1H decoupling, which leads to a simplified spectral pattern. 1H-decoupled 13C-MRS requires RF coils which support both, 1H and 13C, Larmor frequencies with sufficient electromagnetic isolation between the pathways of the two frequencies. We present the development, evaluation, and first in vivo measurement with a 7 T 3-channel 13C and 4-channel 1H transceiver array optimized for 1H-decoupled 13C-MRS in the posterior human calf muscles. To ensure minimal cross-coupling between 13C and 1H arrays, several strategies were combined: mutual magnetic flux was minimized by coil geometry, two LCC traps were inserted into each 13C element, and band-pass and low-pass filters were integrated along the signal pathways. The developed coil array was successfully tested in phantom and in vivo MR experiments, showing a simplified spectral pattern and increase in signal-to-noise ratio of approximately a factor 2 between non-decoupled and 1H-decoupled spectra in a glucose phantom and the human calf muscle.(VLID)464140

Flexible multi-turn multi-gap coaxial RF coils: design concept and implementation for Magnetic Resonance Imaging at 3 and 7 Tesla

International audienceMagnetic resonance has become a backbone of medical imaging but suffers from inherently low sensitivity. This can be alleviated by improved radio frequency (RF) coils. Multi-turn multi-gap coaxial coils (MTMG-CCs) introduced in this work are flexible, form-fitting RF coils extending the concept of the single-turn single-gap CC by introducing multiple cable turns and/or gaps. It is demonstrated that this enables free choice of the coil diameter, and thus, optimizing it for the application to a certain anatomical site, while operating at the self-resonance frequency. An equivalent circuit for MTMG-CCs is modeled to predict their resonance frequency. Possible configurations regarding size, number of turns and gaps, and cable types for different B 0 field strengths are calculated. Standard copper wire loop coils (SCs) and flexible CCs made from commercial coaxial cable were fabricated as receive-only coils for 3 T and transmit/receive coils at 7 T with diameters between 4 and 15 cm. Electromagnetic simulations are used to investigate the currents on MTMG-CCs, and demonstrate comparable specific absorption rate of 7 T CCs and SCs. Signal-to-noise ratio (SNR), transmit efficiency, and active detuning performance of CCs were compared in bench tests and MR experiments. For the form-fitted receive-only CCs at 3 T no significant SNR degradation was found as compared to flat SCs on a balloon phantom. Form-fitted transmit/receive CCs at 7 T showed higher transmit efficiency and SNR. MTMG-CCs can be sized to optimize sensitivity, are flexible and lightweight, and could therefore enable the fabrication of wearable coils with improved patient comfort

NMR in Biomedicine / Dynamic multivoxel-localized 31P MRS during plantar flexion exercise with variable knee angle

Exercise studies investigating the metabolic response of calf muscles using 31P MRS are usually performed with a single knee angle. However, during natural movement, the distribution of workload between the main contributors to force, gastrocnemius and soleus is influenced by the knee angle. Hence, it is of interest to measure the respective metabolic response of these muscles to exercise as a function of knee angle using localized spectroscopy. Timeresolved multivoxel 31P MRS at 7 T was performed simultaneously in gastrocnemius medialis and soleus during rest, plantar flexion exercise and recovery in 12 healthy volunteers. This experiment was conducted with four different knee angles. PCr depletions correlated negatively with knee angle in gastrocnemius medialis, decreasing from 7914 % (extended leg) to 3523 %(40), and positively in soleus, increasing from 2021 % to 3625 %; differences were significant. Linear correlations were found between knee angle and endexercise PCr depletions in gastrocnemius medialis (R2=0.8) and soleus (R2=0.53). PCr recovery times and endexercise pH changes that correlated with PCr depletion were consistent with the literature in gastrocnemius medialis and differences between knee angles were significant. These effects were less pronounced in soleus and not significant for comparable PCr depletions. Maximum oxidative capacity calculated for all knee angles was in excellent agreement with the literature and showed no significant changes between different knee angles. In conclusion, these findings confirm that plantar flexion exercise with a straight leg is a suitable paradigm, when data are acquired from gastrocnemius only (using either localized MRS or small surface coils), and that activation of soleus requires the knee to be flexed. The present study comprises a systematic investigation of the effects of the knee angle on metabolic parameters, measured with dynamic multivoxel 31P MRS during muscle exercise and recovery, and the findings should be used in future study design.(VLID)340101

Multi-turn multi-gap transmission line resonators - Concept, design and first implementation at 4.7 T and 7 T

A novel design scheme for monolithic transmission line resonators (TLRs) is presented - the multi-turn multi-gap TLR (MTMG-TLR) design. The MTMG-TLR design enables the construction of TLRs with multiple turns and multiple gaps. This presents an additional degree of freedom in tuning self-resonant TLRs, as their resonance frequency is fully determined by the coil geometry (e.g. diameter, number of turns, conductor width, etc.). The novel design is evaluated at 4.7 T and 7 T by simulations and experiments, where it is demonstrated that MTMG-TLRs can be used for MRI, and that the B1 distribution of MTMG-TLRs strongly depends on the number and distribution of turns. A comparison to conventional loop coils revealed that the B1 performance of MTMG-TLRs is comparable to a loop coil with the same mean diameter; however, lower 10g SAR values were found for MTMG-TLRs. The MTMG-TLR design is expected to bring most benefits at high static field, where it allows for independent size and frequency selection, which cannot be achieved with standard TLR design. However, it also enables more accurate geometric optimization at low static field. Thereby, the MTMG-TLR design preserves the intrinsic advantages of TLRs, i.e. mechanical flexibility, high SAR efficiency, mass production, and coil miniaturization. (C) 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license.I 1371-B24(VLID)309739

A flexible 12-channel transceiver array of transmission line resonators for 7 T MRI.

International audienceA flexible transceiver array based on transmission line resonators (TLRs) combining the advantages of coil arrays with the possibility of form-fitting targeting cardiac MRI at 7 T is presented. The design contains 12 elements which are fabricated on a flexible substrate with rigid PCBs attached on the center of each element to place the interface components, i.e. transmit/receive (T/R) switch, power splitter, pre-amplifier and capacitive tuning/matching circuitry. The mutual coupling between elements is cancelled using a decoupling ring-based technique. The performance of the developed array is evaluated by 3D electromagnetic simulations, bench tests, and MR measurements using phantoms. Efficient inter-element decoupling is demonstrated in flat configuration on a box-shaped phantom (Sij < -19 dB), and bent on a human torso phantom (Sij < -16 dB). Acceleration factors up to 3 can be employed in bent configuration with reasonable g-factors (<1.7) in an ROI at the position of the heart. The array enables geometrical conformity to bodies within a large range of size and shape and is compatible with parallel imaging and parallel transmission techniques